Alcohol Withdrawal Kindling: Mechanisms and Implications for Treatment
Abstract
This article represents the proceedings of a workshop at the 2000 ISBRA Meeting in Yokohama, Japan. The chair was Larry P. Gonzalez. The presentations were (1) EEG indices of sensitization in a murine model of repeated ethanol withdrawals, by Lynn M. Veatch; (2) Long‐term changes in central nervous system function after repeated alcohol withdrawals: Recommendations for the treatment of acute withdrawal, by Larry P. Gonzalez; (3) Differential regulation of GABA A and NMDA receptors by repeated ethanol treatment in cultured mammalian neurons, by Maharaj K. Ticku; and (4) Involvement of GABA A and NMDA receptors in alcohol withdrawal kindling: Implications for treatment, by Howard C. Becker.
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The most plausible biological pathway for alcohol-related epilepsy is described by the 'kindling effect', which postulates that repeated withdrawals, even subclinical, may lead to gradual lowering of the seizure threshold and eventually to the development of epilepsy or unprovoked seizures that occur even in those who no longer consume alcohol.
“The most plausible biological pathway is described by the ‘kindling effect’, which postulates that repeated withdrawals, even subclinical, may lead to gradual lowering of the seizure threshold and eventually to the development of epilepsy, or unprovoked seizures that occur even in those who no longer consume alcohol 231, 232.”
From The relationship between different dimensions of alcohol use and the burden of disease—an update (2017) · cites this paper as [232]
Cites
A permanent change in brain function resulting from daily electrical stimulation
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Kindling as a Model for Alcohol Withdrawal Syndromes
Ballenger, J. C., & Post, R. M. (1978) · British Journal of Psychiatry · doi:10.1192/bjp.133.1.1 · Cited by 463 · see citing works
Kindling: basic mechanisms and clinical validity
Sato, M., Racine, R. J., & McIntyre, D. (1990) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(90)90099-6 · Cited by 314 · see citing works
Becker, H. C., & Hale, R. L. (1993) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1993.tb00731.x · Cited by 285 · see citing works
Self-citationAlcohol detoxification and withdrawal seizures: Clinical support for a kindling hypothesis
Brown, M. E., Anton, R. F., Malcolm, R. J., & Ballenger, J. C. (1988) · Biological Psychiatry · doi:10.1016/0006-3223(88)90023-6 · Cited by 276 · see citing works
Kokka, N., Sapp, D. W., Taylor, A. M., & Olsen, R. W. (1993) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1993.tb00793.x · Cited by 147 · see citing works
Repeated Ethanol Withdrawal Produces Site‐Dependent Increases in EEG Spiking
Veatch, L. M., & Gonzalez, L. P. (1996) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1996.tb01638.x · Cited by 95 · see citing works
Self-citationDevelopment of New Pharmacological Agents for Epilepsy: Lessons from the Kindling Model
McNamara, J. O. (1989) · Epilepsia · doi:10.1111/j.1528-1157.1989.tb05809.x · Cited by 68 · see citing works
Alcohol withdrawal seizures: Implications of kindling
Pinel, J. P. J. (1980) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(80)80034-7 · Cited by 65 · see citing works
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Self-citationMhatre, M., McKenzie, S. E., & Gonzalez, L. P. (2001) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(00)00481-0 · Cited by 25 · see citing works
Self-citationNifedipine Alleviates Alterations in Hippocampal Kindling After Repeated Ethanol Withdrawal
Veatch, L. M., & Gonzalez, L. P. (2000) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2000.tb02015.x · Cited by 22 · see citing works
Self-citationIncreased Ro15-4513–Induced Seizures Following Multiple Ethanol Withdrawals
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The relationship between different dimensions of alcohol use and the burden of disease—an update
Rehm, J., Gmel, G. E., Gmel, G., Hasan, O. S. M., Imtiaz, S., Popova, S., Probst, C., Roerecke, M., Room, R., Samokhvalov, A. V., et al. (2017) · Addiction · doi:10.1111/add.13757 · Cited by 1,204 · see citing works
- Authors
- Gonzalez, L. P., Veatch, L. M., Ticku, M. K., & Becker, H. C.
- Affiliations
- Medical University of South Carolina (US)
- Corresponding author
- Gonzalez, Larry P.
- ORCID
- Becker, Howard C.
- Venue
- Alcoholism: Clinical and Experimental Research
- Publisher
- Wiley
- Published
- 2001-05
- Volume
- 25
- Issue
- s1
- ISSN
- 0145-6008 (ISSN-L)
- 1530-0277
- OpenAlex
- W4237626476
- Cited by
- 35
- References
- 13
- Citations by year
- 2024: 1 · 2022: 1 · 2019: 1 · 2017: 2 · 2016: 2 · 2014: 1 · 2013: 2
- FWCI
- 1.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Alcoholism Clinical and Experimental Research (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Alcoholism and Thiamine Deficiency
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Keywords
- alcohol withdrawal treatment, GABAA receptor, NMDA receptor, cultured neurons
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