Increased Ethanol Consumption and Preference in Mice Lacking Neurotensin Receptor Type 2: NEUROTENSIN RECEPTOR TYPE 2 AND ALCOHOLISM
Open accessAbstract
BACKGROUND: Neurotensin receptors (NTS) regulate a variety of the biological functions of neurotensin (NT) in the central nervous system. Although NT and neurotensin receptors type 1 (NTS1) are implicated in some of the behavioral effects of ethanol, the functional roles of neurotensin receptors type 2 (NTS2) in ethanol intoxication and consumption remain unknown. Here, we investigated behavioral effects mediated by NTS2 in response to ethanol, which are implicated in ethanol consumption and preference, using NTS2 null mice. METHOD: First, we examined ethanol-induced locomotion, ataxia, hypnosis, and hypothermia in NTS2 null mice. Next, we measured ethanol consumption and preference in NTS2 null mice by giving them free choice between ethanol- and tap water-containing bottles. Then using a brain-permeable NT analog, NT69L, we examined the role of NTS2 in locomotor activity and ataxia. Finally, we examined the effect of NT69L on ethanol consumption and preference in NTS2 null mice. RESULTS: We found that NTS2 null mice appear less sensitive to the acute hypnotic effects of ethanol and consumed more ethanol compared to wild-type littermates in a 2-bottle choice experiment, even though ethanol-induced locomotion, ataxia, and hypothermia were similar between genotypes. Interestingly, the administration of NT69L for 4 consecutive days significantly reduced alcohol consumption and preference in wild-type littermates as well as in NTS2 null mice. CONCLUSIONS: Our findings suggest that NTS2 regulates ethanol-induced hypnosis and ethanol consumption.
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NTSR2 has been found to regulate ethanol consumption in mice.
“NTSR2, which has been found to regulate ethanol consumption in mice35”
From Oxytocin pathway gene networks in the human brain (2019) · cites this paper as [35]
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- Authors
- Lee, M. R., Hinton, D. J., Unal, S. S., Richelson, E., & Choi, D.-S.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Choi, Doo-Sup
- ORCID
- Choi, Doo-Sup
- Venue
- Alcoholism: Clinical and Experimental Research
- Publisher
- Wiley
- Published
- 2010-10-06
- Volume
- 35
- Issue
- 1
- Pages
- 99-107
- ISSN
- 0145-6008 (ISSN-L)
- PMC
- PMC3058519
- OpenAlex
- W1722439486
- Cited by
- 32
- References
- 60
- Citations by year
- 2024: 2 · 2023: 6 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 4 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 1 · 2014: 3 · 2013: 3
- FWCI
- 0.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Alcoholism Clinical and Experimental Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R01AA015164, R01AA018779, P20AA017830)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- neurotensin, ethanol consumption, ethanol preference, ethanol intoxication, locomotor activity, ataxia, hypothermia, alcoholism
- MeSH terms
- Alcohol Drinking, Ethanol, Animals, Body Temperature, Male, Mice, Inbred C57BL, Motor Activity, Neurotensin, Peptide Fragments, Receptors, Neurotensin, Mice, Knockout, Mice, Taste Perception
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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