Is there an anemia responsive to pantothenic acid?
Abstract
ABSTRACT Upon admission to the hospital, a 53‐year‐old black woman showed anorexia, weight loss, lethargy, incontinence and hypochromic anemia with increased storage of iron in the bone marrow. After an unsuccessful trial of pyridoxine, all symptoms and signs improved dramatically following administration of pantothenic acid. (At the time of admission, chest x‐ray findings were such that INH‐streptomycin therapy was started.) She was discharged 6.5 months after entry. For several years thereafter she received no vitamin therapy, and a similar clinical picture again developed. There was a clinical, but probably not a hematologic, response to a multiple‐vitamin preparation containing large amounts of pantothenic acid. At this time and later, the course was complicated by cancer of the cervix, from which the patient died.
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Cites
Sternal marrow hemosiderin; a method for the determination of available iron stores in man.
Rath, C. E., & FINCH, C. A. (1948) · PubMed · Cited by 171 · see citing works
HUMAN PANTOTHENIC ACID DEFICIENCY PRODUCED BY OMEGA-METHYL PANTOTHENIC ACID *
Hodges, R. E., BEAN, W. B., Ohlson, M. A., & Bleiler, R. E. (1959) · Journal of Clinical Investigation · doi:10.1172/jci103918 · Cited by 53 · see citing works
H, R. H. (1979) · Journal of The Royal Naval Medical Service · doi:10.1136/jrnms-65-176 · Cited by 36 · see citing works
Pyridoxine-Responsive Anemia Conditioned by Isonicotinic Acid Hydrazide
McCurdy, P. R., & Donohoe, R. F. (1966) · Blood · doi:10.1182/blood.v27.3.352.352 · Cited by 35 · see citing works
Self-citationVitamin Interrelationships in Heme Synthesis
Richert, D. A., & Schulman, M. P. (1959) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/7.4.416 · Cited by 18 · see citing works
PANTOTHENIC ACID DEFICIENCY IN SWINE
(1944) · Nutrition Reviews · doi:10.1111/j.1753-4887.1944.tb08224.x · Cited by 15 · see citing works
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Tardy, A.-L., Pouteau, E., Marquez, D., Yilmaz, C., & Scholey, A. (2020) · Nutrients · doi:10.3390/nu12010228 · Cited by 541 · see citing works
- Authors
- McCURDY, P. R.
- Affiliations
- Georgetown University (US)
- Corresponding author
- McCURDY, PAUL R.
- Venue
- Journal of the American Geriatrics Society
- Publisher
- Wiley
- Published
- 1973-02
- Volume
- 21
- Issue
- 2
- Pages
- 88-91
- ISSN
- 0002-8614 (ISSN-L)
- 1532-5415
- OpenAlex
- W2046225744
- Cited by
- 2
- References
- 6
- Citations by year
- 2020: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Geriatrics Society (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Keywords
- pantothenic acid, hypochromic anemia, pyridoxine, iron storage, bone marrow iron, anorexia, weight loss, older women, recurrent anemia
- MeSH terms
- Anemia, Hypochromic, Erythrocyte Count, Female, Hematocrit, Humans, Isoniazid, Middle Aged, Pantothenic Acid, Pyridoxine, Reticulocytes, Streptomycin, Tuberculosis, Pulmonary
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