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Cited by 40Growth Hormone and Insulin-like Growth FactorsCardiovascular and exercise physiologyGenetics and Physical Performance

The relationship between aerobic exercise capacity and circulating IGF-1 levels in healthy men and women

Haydar, Ziad R., Blackman, Marc R., Tobin, Jordan D., Wright, Jeanette G., Fleg, Jerome L.·2000·Journal of the American Geriatrics Society
DOI 10.1111/j.1532-5415.2000.tb03904.x
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Abstract

OBJECTIVES: To determine whether aerobic capacity is associated independently with insulin-like growth factor-I (IGF-1) levels in healthy community-dwelling men and women. SETTING: The Baltimore Longitudinal Study on Aging (BLSA). DESIGN: A cross-sectional analysis of data from the population-based cohort of the Baltimore Longitudinal Study of Aging (BLSA). PARTICIPANTS: We studied 181 men and 92 women aged 20 to 93 years, volunteers in the Baltimore Longitudinal Study on Aging (BLSA). Subjects were free of endocrine, renal, hepatic, gastrointestinal, or cardiac diseases, and they were taking no medications known to interfere with the growth hormone-IGF-1 axis. MEASUREMENTS: All subjects underwent a single measurement of serum IGF-1 in the fasting state, as well as peak VO2 determinations during maximal treadmill exercise testing performed within one visit of the IGF-1 determination. Dual energy X-ray absorptiometry (DEXA) scans were performed in a subset of 171 subjects (64 women and 107 men) for determination of fat free mass (FFM). RESULTS: In the pooled group of women and men, univariate regression analysis revealed that age was correlated strongly with decreasing IGF-1 levels (r = -0.53, P < .001) and with peak VO2r = -0.56, P < .001). IGF-1 levels were also significantly correlated with peak VO2 (r = 0.29, P < .001). There were no significant gender-related differences in these relationships. On multivariate analysis, age (beta = -0.54, P < .001), but not peak VO2 (P = -0.01, P = .840), remained strongly associated with IGF-1 levels. After adjustment of peak VO2 for FFM in subjects with DEXA scans, results were similar. CONCLUSIONS: These findings indicate that although both peak aerobic capacity and circulating IGF-1 levels decline with age, aerobic capacity is not independently related to circulating IGF-1 in healthy men and women across the adult life span.

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Authors
Haydar, Z. R., Blackman, M. R., Tobin, J. D., Wright, J. G., & Fleg, J. L.
Affiliations
  • Johns Hopkins University (US)
  • National Institutes of Health (US)
Corresponding author
Fleg, Jerome L.
ORCID
Fleg, Jerome L.
Venue
Journal of the American Geriatrics Society
Publisher
Wiley
Published
2000-02
Volume
48
Issue
2
Pages
139-145
ISSN
  • 0002-8614 (ISSN-L)
  • 1532-5415
DOI
10.1111/j.1532-5415.2000.tb03904.x
OpenAlex
W1980421166
Cited by
40
References
20
Citations by year
2025: 2 · 2024: 3 · 2022: 1 · 2021: 2 · 2020: 3 · 2018: 3 · 2013: 2 · 2012: 1
FWCI
1.94
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 5564 d)
Locations
  • Journal of the American Geriatrics Society (publishedVersion)
  • PubMed (publishedVersion)
Funders
Kementerian Pendidikan Nasional
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Physical Performance
Keywords
insulin-like growth factor I, aerobic exercise capacity, peak oxygen uptake, aging, fat-free mass, growth hormone/IGF-1 axis, sex differences, age-related decline
MeSH terms
Adult, Age Factors, Aged, Aged, 80 and over, Aging, Body Composition, Cross-Sectional Studies, Exercise Test, Fasting, Female, Humans, Insulin-Like Growth Factor I, Longitudinal Studies, Male, Middle Aged, Oxygen Consumption, Population Surveillance, Regression Analysis, Sex Factors, Cohort Studies, Exercise, Absorptiometry, Photon, Multivariate Analysis, Exercise Tolerance, Muscle, Skeletal

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