Cited by 326Dementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration MechanismsAdipokines, Inflammation, and Metabolic Diseases

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Systemic Markers of Inflammation and Cognitive Decline in Old Age

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Schram, Miranda T., Euser, Sjoerd M., De Craen, Anton J. M., Witteman, Jacqueline C., Frölich, Marijke, Hofman, Albert, Jolles, Jelle, Breteler, Monique M. B., Westendorp, Rudi G. J.·2007·Journal of the American Geriatrics Society

DOI 10.1111/j.1532-5415.2007.01159.x

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Abstract

OBJECTIVES: To investigate whether higher circulating levels of C‐reactive protein (CRP), interleukin‐6 (IL‐6), and α1‐antichymotrypsin (ACT) are associated with worse cognitive function and decline in old age. DESIGN: Two independent population‐based cohort studies. SETTING: The Rotterdam Study (mean follow‐up 4.6 years) and the Leiden 85‐plus Study (maximal follow‐up 5 years). PARTICIPANTS: Three thousand eight hundred seventy‐four individuals, mean age 72, from the Rotterdam Study, and 491 individuals, all aged 85, from the Leiden 85‐plus Study. MEASUREMENTS: Both studies assessed global cognition, executive function, and memory. Linear regression analyses were used in the current study to investigate the associations between inflammatory markers and cognitive function and decline. RESULTS: In the Rotterdam Study, higher levels of CRP and IL‐6 were cross‐sectionally associated with worse global cognition and executive function ( P <.05). ACT was not associated with cognitive function. In the Leiden 85‐plus Study, estimates were similar for CRP, although not statistically significant. Higher IL‐6 levels were related to a steeper annual decline in memory function in the longitudinal analysis in the Leiden 85‐plus Study ( P <.05). The effect of higher IL‐6 levels on global and memory function decline was stronger in apolipoprotein E (APOE) ɛ4 carriers ( P ‐interaction=.01) than in those who were not ( P ‐interaction=.05). In the Rotterdam Study, higher IL‐6 levels were related to a steeper annual decline in global cognition in APOE ɛ4 carriers only. CONCLUSION: Systemic markers of inflammation are only moderately associated with cognitive function and decline and tend to be stronger in carriers of the APOE ɛ4 allele. Systemic markers of inflammation are not suitable for risk stratification.

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Authors: Schram, M. T., Euser, S. M., De Craen, A. J. M., Witteman, J. C., Frölich, M., Hofman, A., Jolles, J., Breteler, M. M. B., & Westendorp, R. G. J.
Affiliations: Leiden University Medical Center (NL)
ORCID: Schram, Miranda T.
Euser, Sjoerd M.
De Craen, Anton J. M.
Breteler, Monique M. B.
Westendorp, Rudi G. J.
Venue: Journal of the American Geriatrics Society
Publisher: Wiley
Published: 2007-04-11
Volume: 55
Issue: 5
Pages: 708-716
ISSN: 0002-8614 (ISSN-L)
1532-5415
DOI: 10.1111/j.1532-5415.2007.01159.x
OpenAlex: W2073481032
Cited by: 326
References: 32
Citations by year: 2026: 7 · 2025: 10 · 2024: 15 · 2023: 20 · 2022: 28 · 2021: 15 · 2020: 19 · 2019: 21 · 2018: 17 · 2017: 14 · 2016: 27 · 2015: 19 · 2014: 20 · 2013: 18 · 2012: 9
FWCI: 10.65
Type: journal article
Language: en
Open access: green
cris.maastrichtuniversity.nl
Licence: other-oa
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of the American Geriatrics Society (publishedVersion)
PubMed (publishedVersion)
Research Publications (Maastricht University) (publishedVersion, other-oa)
EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
Research Publications (Maastricht University) (submittedVersion, other-oa)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: systemic inflammation, cognitive decline, C-reactive protein, interleukin-6, alpha-1-antichymotrypsin, APOE ε4, older adults, executive function, memory decline, global cognition, risk stratification
MeSH terms: Aged, Aged, 80 and over, alpha 1-Antichymotrypsin, C-Reactive Protein, Cognition Disorders, Female, Follow-Up Studies, Humans, Inflammation, Male, Middle Aged, Biomarkers, Interleukin-6, Inflammation Mediators, Apolipoprotein E4

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Systemic Markers of Inflammation and Cognitive Decline in Old Age

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