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Sleep Deprivation and Epilepsy
Open accessAbstract
A patient with epilepsy should “spend the day awake and the night asleep. If this habit be disturbed, it is not so good … worse of all when he sleeps neither night nor day.”—Hippocrates ( 1 ) This review summarizes the data for and against sleep deprivation as a facilitator of epileptic seizures and interictal epileptiform discharges. Much of these data are derived from clinical studies; however, basic science investigations are greatly needed to determine the influence of sleep deprivation on seizure susceptibility and neuronal function. Study of the effects of sleep deprivation on epilepsy may create a window of opportunity that could help decipher how seizures are triggered and facilitated, potentially providing an avenue for future interventions.
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Sleep deprivation reduces learning, impairs performance in cognitive tests, prolongs reaction time, and is a common cause of seizures.
“Sleep deprivation reduces learning, impairs performance in cognitive tests, prolongs reaction time, and is a common cause of seizures (3, 4).”
From Sleep Drives Metabolite Clearance from the Adult Brain (2013) · cites this paper as [3]
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Cited by
Sorted by citations
Sleep Drives Metabolite Clearance from the Adult Brain
Xie, L., Kang, H., Xu, Q., Chen, M. J., Liao, Y., Thiyagarajan, M., O’Donnell, J., Christensen, D. J., Nicholson, C., Iliff, J. J., et al. (2013) · Science · doi:10.1126/science.1241224 · Cited by 5,411
A forward-looking review of seizure prediction
Freestone, D. R., Karoly, P. J., & Cook, M. J. (2017) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000429 · Cited by 169
Neurophysiological correlates of sleepiness: a combined TMS and EEG study
De Gennaro, L., Marzano, C., Veniero, D., Moroni, F., Fratello, F., Curcio, G., Ferrara, M., Ferlazzo, F., Novelli, L., Concetta Pellicciari, M., et al. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.04.013 · Cited by 147
Properties of REM sleep alterations with epilepsy
Ikoma, Y., Takahashi, Y., Sasaki, D., & Matsui, K. (2023) · Brain · doi:10.1093/brain/awac499 · Cited by 33
Metadata
- Authors
- Malow, B. A.
- Affiliations
- Vanderbilt University Medical Center (US)
- Corresponding author
- Malow, Beth A.
- ORCID
- Malow, Beth A.
- Venue
- Epilepsy Currents
- Publisher
- SAGE Publications
- Published
- 2004-09
- Volume
- 4
- Issue
- 5
- Pages
- 193-195
- ISSN
- 1535-7511 (ISSN-L)
- 1535-7597
- PMC
- PMC1176369
- OpenAlex
- W2034932565
- Cited by
- 154
- References
- 0
- Citations by year
- 2026: 11 · 2025: 9 · 2024: 5 · 2023: 19 · 2022: 13 · 2021: 13 · 2020: 13 · 2019: 8 · 2018: 6 · 2017: 6 · 2016: 7 · 2015: 7 · 2014: 7 · 2013: 11 · 2012: 4
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Epiliepsy currents/Epilepsy currents (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- sleep deprivation, epilepsy, epileptic seizures, interictal epileptiform discharges, seizure susceptibility, seizure triggers, neuronal function
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