Sleep Loss Reduces Diurnal Rhythm Amplitude of Leptin in Healthy Men
Abstract
The aim of the current study was to investigate the effects of sleep loss on the diurnal rhythm of circulating leptin levels. An indwelling forearm catheter was used to sample blood at 90‐min intervals for a total of 120 h, which included 88 h of sustained sleeplessness, in 10 healthy men. The diurnal amplitude of leptin was reduced during total sleep deprivation and returned toward normal during the period of recovery sleep. This finding provides evidence that sleep influences the nocturnal leptin profile, and may have implications for the understanding of the role of sleep in metabolic regulation and the aetiologies of obesity and the night eating syndrome.
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The relationship between sleep and metabolism has been extensively studied in human subjects under varying conditions, such as total sleep deprivation, partial sleep deprivation, and sleep fragmentation.
“The relationship between sleep and metabolism has been extensively studied in human subjects under varying conditions, such as total sleep deprivation,87–100 partial sleep deprivation,101–122 and sleep fragmentation123–125 (Table 1).”
From Interacting epidemics? Sleep curtailment, insulin resistance, and obesity (2012) · cites this paper as [94]
Continuous total sleep deprivation for 88 hours in healthy men decreased the nocturnal amplitude of leptin (p<0.001).
“Continuous total sleep deprivation for 88 hours in healthy men (body mass index (BMI) range: 20–34.5 kg/m2) decreased the nocturnal amplitude of leptin (p<0.001) [38].”
From Association between sleep deficiency and cardiometabolic disease: implications for health disparities (2016) · cites this paper as [38]
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- Authors
- Mullington, J. M., Chan, J. L., Van Dongen, H. P. A., Szuba, M. P., Samaras, J., Price, N. J., Meier‐Ewert, H. K., Dinges, D. F., & Mantzoros, C. S.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- University of Pennsylvania (US)
- Corresponding author
- Mullington, J. M.
- Venue
- Journal of Neuroendocrinology
- Publisher
- Wiley
- Published
- 2003-08-04
- Volume
- 15
- Issue
- 9
- Pages
- 851-854
- ISSN
- 0953-8194 (ISSN-L)
- 1365-2826
- OpenAlex
- W1591122824
- Cited by
- 261
- References
- 30
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 2 · 2023: 7 · 2022: 9 · 2021: 8 · 2020: 12 · 2019: 8 · 2018: 8 · 2017: 9 · 2016: 14 · 2015: 14 · 2014: 15 · 2013: 14 · 2012: 21
- FWCI
- 4.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsches Krebsforschungszentrum
- U.S. Public Health Service (R0-158785)
- National Heart, Lung, and Blood Institute (HL70154, R01HL070154)
- National Institute of Mental Health (R01MH060641, MH 60641)
- Air Force Office of Scientific Research
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- sleep deprivation, leptin, circadian rhythm, recovery sleep, metabolic regulation, obesity, night eating syndrome
- MeSH terms
- Adult, Circadian Rhythm, Humans, Male, Reference Values, Sleep, Sleep Deprivation, Leptin
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