The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Adenosine-sensitive atrial tachycardia
Abstract
Limited data suggest that adenosine termination of atrial tachycardia is uncommon. To investigate further the effect of adenosine on atrial tachycardia, adenosine (6-12 mg) was administered during sustained atrial tachycardia in 17 patients. All patients underwent electrophysiological study to exclude other mechanisms of supraventricular tachycardia. Mean patient age was 51 +/- 20 years (range 18-82 years). Seven patients had no structural heart disease. The mean atrial tachycardia cycle length was 390 +/- 80 msecs (range 260-580). Sustained atrial tachycardia was induced with atrial extrastimuli in 8 patients, and was either incessant at baseline or developed spontaneously during isoproterenol infusion in 9 patients. Adenosine terminated atrial tachycardia in 3 patients (18%), transiently suppressed atrial tachycardia in 4 patients (23%), and produced AV block without affecting tachycardia cycle length in the remaining 10 patients. Adenosine sensitivity was observed in 3 of 8 patients with tachycardias initiated and terminated by atrial extrastimuli, and in 4 of 9 patients with spontaneous, but not inducible tachycardias including 3 of 4 patients with isoproterenol facilitated tachycardias. Of multiple clinical and electrophysiological variables examined as potential predictors of adenosine sensitivity, only isoproterenol facilitation of spontaneous or inducible sustained tachycardia predicted adenosine sensitivity (P = 0.02). These observations suggest that adenosine-sensitive atrial tachycardia may be more common than previously recognized. Adenosine sensitivity does not appear to be specific for tachycardia mechanism and cannot be predicted by response to pacing. Atrial tachycardias dependent on beta-adrenergic stimulation are most likely to be terminated by adenosine.
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Intravenous adenosine has been shown to terminate AT, particularly focal, but the tachycardia may continue with AV block.
“Intravenous adenosine has been shown to terminate AT, particularly when there is a focal origin, but the tachycardia may continue with AV block.103,105”
From European Heart Rhythm Association (EHRA) consensus document on the management of supraventricular arrhythmias, endorsed by Heart Rhythm Society (HRS), Asia-Pacific Heart Rhythm Society (APHRS), and Sociedad Latinoamericana de Estimulacion Cardiaca y Electrofisiologia (SOLAECE) (2017) · cites this paper as [105]
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Metadata
- Authors
- KALL, J. G., KOPP, D., OLSHANSKY, B., KINDER, C., O'CONNOR, M., CADMAN, C. S., & WILBER, D.
- Affiliations
- Loyola University Medical Center (US)
- Corresponding author
- KALL, JOHN G.
- ORCID
- OLSHANSKY, BRIAN
- Venue
- Pacing and Clinical Electrophysiology
- Publisher
- Wiley
- Published
- 1995-02
- Volume
- 18
- Issue
- 2
- Pages
- 300-306
- ISSN
- 0147-8389 (ISSN-L)
- 1540-8159
- OpenAlex
- W2033632326
- Cited by
- 39
- References
- 21
- Citations by year
- 2025: 2 · 2024: 2 · 2020: 1 · 2016: 3 · 2015: 6 · 2013: 1
- FWCI
- 1.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pacing and Clinical Electrophysiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Keywords
- adenosine, atrial tachycardia, supraventricular tachycardia, atrioventricular block, beta-adrenergic stimulation, tachycardia termination
- MeSH terms
- Adenosine, Cardiac Pacing, Artificial, Electrocardiography, Female, Heart Block, Heart Conduction System, Humans, Isoproterenol, Male, Middle Aged, Tachycardia, Supraventricular, Catheter Ablation
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