The transmural activation sequence in porcine and canine left ventricle is markedly different during long-duration ventricular fibrillation
Abstract
Background: Humans are more similar in transmural Purkinje and cardiac ion channel distributions to dogs than pigs. The Purkinje network in pigs is transmural but confined to the endocardium in dogs. Little is known about intramural activation during long‐duration ventricular fibrillation (LDVF) given these differences. We tested the hypothesis that the transmural activation sequence is similar in sinus rhythm (SR) and LDVF in dogs as well as pigs, but different between species. Methods and Results: In six pigs and seven dogs, 50–60 plunge needles (six electrodes, 2‐mm spacing) were placed throughout the left ventricle. Unipolar recordings were made for >10 minutes of LDVF. SR and LDVF activation times were grouped into waves by linking activations along each needle. Origin (earliest activation) and propagation direction were determined for each wave. The mean wave origin was significantly more endocardial in dogs than pigs for SR and 1 through 10 minutes of LDVF. Predominant propagation direction in LDVF and SR was endocardial to epicardial in dogs, but the opposite or equal in both directions in pigs. Fastest activation rate was epicardial in pigs, but endocardial in dogs with an increasing endocardial‐to‐epicardial activation rate gradient as LDVF progressed in dogs but not pigs. Conclusions: The transmural activation sequence in SR and LDVF is markedly different between pigs and dogs. These differences may be related to differences in Purkinje fiber and ion channel distributions and suggest that dogs are a better model for investigating activation sequences during LDVF, given the similarities with humans.
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There is a high degree of resemblance between human and canine sino-atrial node activity and structure, purkinje fiber distribution, and activation sequence.
“there is a high degree of resemblance between human and canine sino-atrial (SA) node activity and structure (Review: (Fedorov, Glukhov, & Chang, 2012)), purkinje fiber distribution, and activation sequence (Allison, et al., 2007; Hamlin, 2007).”
From Small and large animal models in cardiac contraction research: advantages and disadvantages (2014) · cites this paper as Allison, et al., 2007
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Small and large animal models in cardiac contraction research: advantages and disadvantages
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- Authors
- ALLISON, J. S., QIN, H., DOSDALL, D. J., HUANG, J., NEWTON, J. C., ALLRED, J. D., SMITH, W. M., & IDEKER, R. E.
- Affiliations
- University of Alabama at Birmingham (US)
- Corresponding author
- IDEKER, RAYMOND E.
- Venue
- Journal of Cardiovascular Electrophysiology
- Publisher
- Wiley
- Published
- 2007-10-25
- Volume
- 18
- Issue
- 12
- Pages
- 1306-1312
- ISSN
- 1045-3873 (ISSN-L)
- 1540-8167
- OpenAlex
- W2048008314
- Cited by
- 70
- References
- 25
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 2 · 2021: 4 · 2020: 1 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 3 · 2014: 3 · 2013: 5 · 2012: 3
- FWCI
- 7.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cardiovascular Electrophysiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
- Keywords
- left ventricle, Purkinje network, species differences, pigs, dogs, propagation direction
- MeSH terms
- Animals, Dogs, Heart Conduction System, Heart Ventricles, Species Specificity, Swine, Ventricular Fibrillation, Ventricular Dysfunction, Left
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