Cited by 1,290Heart Rate Variability and Autonomic ControlCardiac electrophysiology and arrhythmiasECG Monitoring and Analysis

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Heart rate variability: measurement and clinical utility.

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Kleiger, Robert E., Stein, Phyllis K., Bigger, J. Thomas·2005·Annals of Noninvasive Electrocardiology

DOI 10.1111/j.1542-474x.2005.10101.xPMC PMC6932537

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Abstract

Electrocardiographic RR intervals fluctuate cyclically, modulated by ventilation, baroreflexes, and other genetic and environmental factors that are mediated through the autonomic nervous system. Short term electrocardiographic recordings (5 to 15 minutes), made under controlled conditions, e.g., lying supine or standing or tilted upright can elucidate physiologic, pharmacologic, or pathologic changes in autonomic nervous system function. Long‐term, usually 24‐hour recordings, can be used to assess autonomic nervous responses during normal daily activities in health, disease, and in response to therapeutic interventions, e.g., exercise or drugs. RR interval variability is useful for assessing risk of cardiovascular death or arrhythmic events, especially when combined with other tests, e.g., left ventricular ejection fraction or ventricular arrhythmias.

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See all 1,290

Authors: Kleiger, R. E., Stein, P. K., & Bigger, J. T.
Affiliations: Washington University in St. Louis (US)
Columbia University (US)
Corresponding author: Bigger, J. Thomas
ORCID: Stein, Phyllis K.
Venue: Annals of Noninvasive Electrocardiology
Publisher: Wiley
Published: 2005-01
Volume: 10
Issue: 1
Pages: 88-101
ISSN: 1082-720X (ISSN-L)
1542-474X
DOI: 10.1111/j.1542-474x.2005.10101.x
PMC: PMC6932537
OpenAlex: W2082227074
Cited by: 1,290
References: 118
Citations by year: 2026: 50 · 2025: 80 · 2024: 100 · 2023: 104 · 2022: 85 · 2021: 99 · 2020: 82 · 2019: 75 · 2018: 56 · 2017: 60 · 2016: 63 · 2015: 53 · 2014: 61 · 2013: 49 · 2012: 60
FWCI: 4.56
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 12 d)
Locations: Annals of Noninvasive Electrocardiology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › ECG Monitoring and Analysis
Keywords: heart rate variability, RR interval variability, autonomic nervous system, baroreflex, autonomic function testing, 24-hour Holter monitoring, cardiovascular risk, arrhythmia risk, exercise testing
MeSH terms: Autonomic Nervous System, Cardiovascular Diseases, Electrocardiography, Heart Conduction System, Heart Rate, Humans, Time Factors

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