Respiratory sinus arrhythmia in the denervated human heart
Abstract
We performed this study to test whether the denervated human heart has the ability to manifest respiratory sinus arrhythmia (RSA). With the use of a highly sensitive spectral analysis technique (cross correlation) to define beat-to-beat coupling between respiratory frequency and heart rate period (R-R) and hence RSA, we compared the effects of patterned breathing at defined respiratory frequency and tidal volumes (VT), Valsalva and Mueller maneuvers, single deep breaths, and unpatterned spontaneous breathing on RSA in 12 normal volunteers and 8 cardiac allograft transplant recipients. In normal subjects R-R changes closely followed changes in respiratory frequency (P less than 0.001) but were little affected by changes in VT. On the R-R spectrum, an oscillation peak synchronous with respiration was found in heart transplant patients. However, the average magnitude of the respiration-related oscillations was 1.7–7.9% that seen in normal subjects and was proportionally more influenced by changes in VT. Changes in R-R induced by Valsalva and Mueller maneuvers were 3.8 and 4.9% of those seen in normal subjects, respectively, whereas changes in R-R induced by single deep breaths were 14.3% of those seen in normal subjects. The magnitude of RSA was not related to time since the heart transplantation, neither was it related to patient age or sex. Thus the heart has the intrinsic ability to vary heart rate in synchrony with ventilation, consistent with the hypothesis that changes, or rate of changes, in myocardial wall stretch might alter intrinsic heart rate independent of autonomic tone.
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RSA is more marked during slow-paced breathing and at lower respiration rates (0.1 Hz and below).
“RSA is seen to be more marked during slow-paced breathing and at lower respiration rates (0.1 Hz and below).”
From Music structure determines heart rate variability of singers (2013) · cites this paper as Bernardi et al., 1989
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Quinn, T. A., & Kohl, P. K. (2016) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2016.05.003 · Cited by 44 · see citing works
Chen, X., & Mukkamala, R. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01061.2007 · Cited by 45 · see citing works
Autonomic cardiac control in depressed adolescents
Byrne, M. L., Sheeber, L., Simmons, J. G., Davis, B., Shortt, J. W., Katz, L. F., & Allen, N. B. (2010) · Depression and Anxiety · doi:10.1002/da.20717 · Cited by 44 · see citing works
Functional restitution of cardiac control in heart transplant patients
Toledo, E., Pinhas, I., Aravot, D. J., Almog, Y., & AKSELROD, S. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00467.2001 · Cited by 45 · see citing works
Neostigmine decreases heart rate in heart transplant patients
Backman, S. B., FOX, G. S., Stein, R. D., & Ralley, F. E. (1996) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/bf03011717 · Cited by 44 · see citing works
- Authors
- Bernardi, L., Keller, F., Sanders, M., Reddy, P. S., Griffith, B., Meno, F., & Pinsky, M. R.
- Affiliations
- University of Pittsburgh (US)
- ORCID
- Pinsky, M. R.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 1989-10-01
- Volume
- 67
- Issue
- 4
- Pages
- 1447-1455
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2218308347
- Cited by
- 272
- References
- 0
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 6 · 2023: 2 · 2022: 4 · 2021: 6 · 2020: 7 · 2019: 3 · 2018: 6 · 2017: 11 · 2016: 4 · 2015: 5 · 2014: 5 · 2013: 9 · 2012: 10
- FWCI
- 3.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- D-Scholarship@Pitt (University of Pittsburgh) (acceptedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- respiratory sinus arrhythmia, denervated heart, heart transplantation, cardiac allograft recipients, heart rate variability, respiratory rate, tidal volume, Valsalva maneuver, Mueller maneuver, deep breathing, intrinsic heart rate
- MeSH terms
- Adult, Arrhythmia, Sinus, Denervation, Electrocardiography, Female, Heart, Heart Rate, Humans, Male, Middle Aged, Respiration, Valsalva Maneuver, Heart Transplantation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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