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Cited by 15Cardiac electrophysiology and arrhythmiasHeart Rate Variability and Autonomic ControlECG Monitoring and Analysis

Age and Gender Difference in ST Height at Rest and after Double Autonomic Blockade in Normal Adults

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Endres, Susanne, Mayuga, Kenneth A., De Cristofaro, Alessandro, Taneja, Taresh, Goldberger, Jeffrey J., Kadish, Alan H.·2006·Annals of Noninvasive Electrocardiology
DOI 10.1111/j.1542-474x.2006.00112.xPMC PMC6932513
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Abstract

Background: ST elevation is commonly seen in young, healthy men. The exact mechanisms that cause ST height to be greater in young men are not yet completely understood. The purpose of the present study was to determine whether autonomic tone is responsible for age and gender differences in ST height. Methods: Gender and age differences in ST height were studied at rest and after double autonomic blockade (DAB) with atropine and propranolol. Fifty healthy men and women were included (16 men, 14 women, age 23–32 years; 9 men, 11 women, age 65–79 years). Twelve‐lead ECGs were registered at rest and after DAB. Leads II and V 1–V 4 were chosen for analysis. ST height (in mm) was measured manually at the J‐point, and 40 ms and 80 ms after the J‐point. Values were corrected for QRS amplitude. Results: Gender and age differences in ST height were seen in both rest and DAB data. Men had greater ST height compared to women at J‐point, 40 and 80 ms after the J‐point (P ≤ 0.0001), and younger subjects had greater ST height than older subjects at J‐point (P = 0.0140), 40 and 80 ms after the J‐point (P ≤ 0.0001). DAB did not change ST height at J‐point or at 40 ms, but increased ST height at 80 ms. Women had less of an increase in ST height following DAB than men did. Conclusions: ST elevation in the absence of structural or electrical heart disease is mainly seen in young men. Age and gender difference persist after DAB and thus are not due to differences in autonomic tone.

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  • Chemical and surgical denervation unmask the intrinsic rate of the sinus node, resulting in an increase in the resting heart rate to around 90 bpm and above.

    “Chemical and surgical denervation unmask the intrinsic rate of the sinus node, resulting in an increase in the resting heart rate to around 90 bpm and above 16–19.”

    From Sinus Tachycardia: a Multidisciplinary Expert Focused Review (2022) · cites this paper as [19]

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Authors
Endres, S., Mayuga, K. A., De Cristofaro, A., Taneja, T., Goldberger, J. J., & Kadish, A. H.
Affiliations
Northwestern University (US)
ORCID
Venue
Annals of Noninvasive Electrocardiology
Publisher
Wiley
Published
2006-07
Volume
11
Issue
3
Pages
253-258
ISSN
  • 1082-720X (ISSN-L)
  • 1542-474X
DOI
10.1111/j.1542-474x.2006.00112.x
PMC
PMC6932513
OpenAlex
W2016859648
Cited by
15
References
27
Citations by year
2022: 1 · 2019: 2 · 2017: 1 · 2016: 1 · 2014: 1 · 2012: 4
FWCI
0.71
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2 d)
Locations
  • Annals of Noninvasive Electrocardiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Touro Scholar (Touro College) (submittedVersion)
Funders
  • National Institutes of Health (1r03ag014490-01)
  • National Institute on Aging (1R03 AG14490-01)
  • National Heart, Lung, and Blood Institute (R01HL075382)
  • National Center for Research Resources (M01 RR00048, M01RR000048)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › ECG Monitoring and Analysis
Keywords
ST-segment elevation, autonomic tone, atropine, propranolol, age differences, sex differences, healthy adults, J point
MeSH terms
Adult, Age Factors, Aged, Atropine, Autonomic Agents, Electrocardiography, Female, Heart, Humans, Male, Middle Aged, Propranolol, Reference Values, Sex Factors

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