Beat‐to‐Beat QT Interval Variability Is Primarily Affected by the Autonomic Nervous System
Open accessAbstract
Background: Beat‐to‐beat QT interval variability is associated with life‐threatening arrhythmias and sudden death, however, its precious mechanism and the autonomic modulation on it remains unclear. The purpose of this study was to determine the effect of drugs that modulate the autonomic nervous system on beat‐to‐beat QT interval. Method: RR and QT intervals were determined for 512 consecutive beats during fixed atrial pacing with and without propranolol and automatic blockade (propranolol plus atropine) in 11 patients without structural heart disease. Studied parameters included: RR, QTpeak (QRS onset to the peak of T wave), QTend (QRS onset to the end of T wave) interval, standard deviation (SD) of the RR, QTpeak, and QTend (RR‐SD, QTpeak‐SD, and QTend‐SD), coefficients of variation (RR‐ CV, QTpeak‐CV, and QTend‐CV) from time domain analysis, total power (TP; RR‐TP, QTpeak‐TP, and QTend‐TP), and power spectral density of the low‐frequency band (LF; RR‐LF, QTpeak‐LF, and QTend‐LF) and the high‐frequency band (HF; RR‐HF, QTpeak‐HF and QTend‐HF). Results: Administration of propranolol and infusion of atropine resulted in the reduction of SD, CV, TP, and HF of the QTend interval when compared to controlled atrial pacing (3.7 ± 0.6 and 3.5 ± 0.5 vs 4.8 ± 1.4 ms, 0.9 ± 0.1 and 0.9 ± 0.1 vs 1.2 ± 0.3%, 7.0 ± 2.2 and 7.0 ± 2.2 vs 13.4 ± 8.1 ms 2, 4.2 ± 1.4 and 4.2 ± 1.2 vs 8.4 ± 4.9 ms 2, respectively). Administration of propranolol and atropine did not affect RR interval or QTpeak interval indices during controlled atrial pacing. Conclusions: Beat‐to‐beat QT interval variability is affected by drugs that modulate the autonomic nervous system.
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Beat-to-beat QT interval variability is affected by drugs that modulate the autonomic nervous system.
“Mine and coworkers 39 demonstrated that beat-to-beat QT interval variability is affected by drugs that modulate the autonomic nervous system.”
From The Year of 2008 in Electrocardiology (2010) · cites this paper as [39]
The parasympathetic system may act preferentially on the QT interval itself while the sympathetic system appears to affect QT interval variability.
“These finding indicated that the parasympathetic system may act preferentially on the QT interval itself while the sympathetic system appears to affect QT interval variability.”
From The Year of 2008 in Electrocardiology (2010) · cites this paper as [39]
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- [19]19. Mesquita ET, Deus FC, Guedes CR, et al Effects of propranolol on the QT dispersion in congestive heart failure. Arq Bras Cardiol 1999;73:291–298. [PubMed] [Google Scholar] Articles from Annals of Noninvasive Electrocardiology : The Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc are provided here courtesy of International Society for Holter and Noninvasive Electrocardiology, Inc. and Wiley Periodicals, Inc.
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The Year of 2008 in Electrocardiology
Stern, S. (2010) · Annals of Noninvasive Electrocardiology · doi:10.1111/j.1542-474x.2009.00347.x · Cited by 1 · see citing works
- Authors
- Mine, T., Shimizu, H., Hiromoto, K., Furukawa, Y., Kanemori, T., Nakamura, H., Masuyama, T., & Ohyanagi, M.
- Affiliations
- Hyogo Medical University (JP)
- Takarazuka City Hospital (JP)
- Osaka Prefectural Medical Center (JP)
- Venue
- Annals of Noninvasive Electrocardiology
- Publisher
- Wiley
- Published
- 2008-07
- Volume
- 13
- Issue
- 3
- Pages
- 228-233
- ISSN
- 1082-720X (ISSN-L)
- 1542-474X
- PMC
- PMC6932129
- OpenAlex
- W2010716250
- Cited by
- 24
- References
- 20
- Citations by year
- 2024: 1 · 2017: 4 · 2016: 2 · 2015: 3 · 2014: 2 · 2013: 3 · 2012: 2
- FWCI
- 1.70
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annals of Noninvasive Electrocardiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
- Keywords
- autonomic nervous system, propranolol, atropine, heart rate variability, atrial pacing, autonomic regulation, sudden cardiac death risk
- MeSH terms
- Aged, Anti-Arrhythmia Agents, Arrhythmias, Cardiac, Atrial Flutter, Atropine, Autonomic Nervous System, Electrocardiography, Female, Humans, Long QT Syndrome, Male, Middle Aged, Propranolol, Sensitivity and Specificity, Severity of Illness Index, Sick Sinus Syndrome, Tachycardia, Supraventricular, Reproducibility of Results, Cohort Studies, Survival Rate, Risk Assessment
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