Electrocardiographic Transmural Dispersion of Repolarization in Patients with Inherited Short QT Syndrome
Open accessAbstract
Background: Short QT syndrome (SQTS) carries an increased risk for sudden cardiac death. However, only a short QT interval does not express the risk of ventricular arrhythmias. Thus, additional evaluation of the repolarization abnormality in SQTS patients is essential. In experimental models of SQTS, increased transmural dispersion of repolarization (TDR) and its electrocardiographic counterpart T‐wave peak to T‐wave end interval (TPE) appeared critical for induction of polymorphic ventricular tachycardia (PMVT). In a clinical study with acquired long QT syndrome patients, TPE/QT ratio > 0.28 indicated arrhythmia risk. We hypothesized that the TPE/QT ratio would be greater in SQTS patients than in control subjects. Methods and Results: We compared the behavior of the electrocardiographic TDR in three seriously symptomatic SQTS patients of unknown genotype presenting baseline QTc values <320 ms and in nine healthy age‐matched control subjects. We determined QT and TPE intervals as well as TPE/QT ratio from 24‐hour ECG recordings using a computer‐assisted program. Diurnal average of TPE/QT ratio was 0.28 ± 0.03 in SQTS patients and 0.21 ± 0.02 in control subjects (P = 0.01). SQTS patients had also lesser capacity to change TPE intervals from steady‐state conditions to abrupt maximal values than control subjects. Conclusion: SQTS patients have increased and autonomically uncontrolled electrocardiographic TDR. According to experimental SQTS models, the present results may in part explain increased vulnerability of SQTS patients to ventricular arrhythmias.
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In patients with short QT syndrome, the diurnal average of TPE/QT ratio is increased compared to control subjects.
“In patients with short QT syndrome (SQTS), which carries a high risk of sudden cardiac death, Anttonen and coworkers 33 measured the T-wave peak to T-wave end interval (TPE) and found an increased diurnal average of TPE/QT ratio, as compared to controlled subjects, showing an increased transmural dispersion of repolarization, explaining possibly the increased vulnerability to ventricular arrhythm”
From The Year of 2008 in Electrocardiology (2010) · cites this paper as [33]
The increased diurnal average of TPE/QT ratio in short QT syndrome shows increased transmural dispersion of repolarization, possibly explaining the increased vulnerability to ventricular arrhythmias.
“showing an increased transmural dispersion of repolarization, explaining possibly the increased vulnerability to ventricular arrhythmias of these patients.”
From The Year of 2008 in Electrocardiology (2010) · cites this paper as [33]
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Cites
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Maury, P., Sacher, F., Gourraud, J.-B., Pasquié, J.-L., Raczka, F., Bongard, V., Duparc, A., Mondoly, P., Sadron, M., Chatel, S., et al. (2015) · Heart Rhythm · doi:10.1016/j.hrthm.2015.07.029 · Cited by 99 · see citing works
The Year of 2008 in Electrocardiology
Stern, S. (2010) · Annals of Noninvasive Electrocardiology · doi:10.1111/j.1542-474x.2009.00347.x · Cited by 1 · see citing works
- Authors
- Anttonen, O., Väänänen, H., Junttila, J., Huikuri, H. V., & Viitasalo, M.
- Affiliations
- Päijät-Hämeen Keskussairaala (FI)
- Aalto University (FI)
- University of Helsinki (FI)
- University of Oulu (FI)
- Venue
- Annals of Noninvasive Electrocardiology
- Publisher
- Wiley
- Published
- 2008-07
- Volume
- 13
- Issue
- 3
- Pages
- 295-300
- ISSN
- 1082-720X (ISSN-L)
- 1542-474X
- PMC
- PMC6932051
- OpenAlex
- W2025805823
- Cited by
- 50
- References
- 15
- Citations by year
- 2025: 2 · 2022: 1 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 1 · 2015: 6 · 2014: 3 · 2013: 5 · 2012: 4
- FWCI
- 4.12
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annals of Noninvasive Electrocardiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Foundation for Cardiovascular Research
- Sydäntutkimussäätiö
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
- Keywords
- short QT syndrome, transmural dispersion of repolarization, sudden cardiac death, ventricular arrhythmias, polymorphic ventricular tachycardia, QTc interval, 24-hour ECG monitoring
- MeSH terms
- Adolescent, Aged, 80 and over, Arrhythmias, Cardiac, Electrocardiography, Follow-Up Studies, Heart Conduction System, Humans, Male, Middle Aged, Myocardial Contraction, Pedigree, Probability, Sampling Studies, Severity of Illness Index, Syndrome, Electrocardiography, Ambulatory, Case-Control Studies, Risk Assessment, Statistics, Nonparametric, Genetic Predisposition to Disease, Ventricular Remodeling, Electrophysiologic Techniques, Cardiac
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