Cardiovascular Importance of the MicroRNA‐23/27/24 Family
Abstract
MicroRNAs (miRNAs) are a class of highly conserved, noncoding short RNA molecules that regulate gene expression on the post-transcriptional level. MiRNAs are involved in a variety of processes such as proliferation, differentiation, and apoptosis. Deregulated expression of miRNAs has been linked to the development of diseases including cardiovascular disorders. Recently, the miR-23/27/24 cluster has been shown to be involved in angiogenesis and endothelial apoptosis in cardiac ischemia and retinal vascular development. In the present review, we summarize and discuss the role and importance of the miRNA-23/27/24 cluster during cardiovascular angiogenesis. Moreover, we illustrate a novel therapeutic application of the miRNA-23/27/24 cluster in vascular disorders and ischemic heart disease.
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The two isoforms of miR-23 can facilitate angiogenesis and influence endothelial cell apoptosis by directly targeting Sprouty2, but they have different effects on endothelial cell function.
“Research has found that the two isoforms of miR-23 can facilitate angiogenesis and influence endothelial cell apoptosis by directly targeting Sprouty2 [42,43], but they have different effects on endothelial cell function.”
From Recent advances of miR-23 in human diseases and growth development (2025) · cites this paper as [43]
miR-23-24-27 clusters are abundantly expressed in endothelial cells and highly vascularized tissues, targeting endothelial junction proteins to protect vascular integrity through functional regulation of endothelial cell junctions.
“As early as 2011, a study discovered that miR-23-24-27 clusters are abundantly expressed in endothelial cells and highly vascularized tissues, targeting a multitude of endothelial junction proteins to protect vascular integrity through the functional regulation of endothelial cell junctions.”
From Recent advances of miR-23 in human diseases and growth development (2025) · cites this paper as [43]
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Self-citationSprouty, an intracellular inhibitor of Ras signaling
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“endothelial apoptosis in cardiac ischemia and retinal vascular development (Bang et al., 2012).”
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Recent advances of miR-23 in human diseases and growth development
Qian, X., Jiang, Y., Yang, Y., Zhang, Y., Xu, N., Xu, B., Pei, K., Yu, Z., & Wu, W. (2025) · Non-coding RNA Research · doi:10.1016/j.ncrna.2024.12.010 · Cited by 5 · see citing works
- Authors
- BANG, C., FIEDLER, J., & THUM, T.
- Affiliations
- Medizinische Hochschule Hannover (DE)
- Corresponding author
- THUM, THOMAS
- Venue
- Microcirculation
- Publisher
- Wiley
- Published
- 2012-03-27
- Volume
- 19
- Issue
- 3
- Pages
- 208-214
- ISSN
- 1073-9688 (ISSN-L)
- 1549-8719
- OpenAlex
- W2099435530
- Cited by
- 90
- References
- 7
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 1 · 2022: 7 · 2021: 11 · 2020: 8 · 2019: 9 · 2018: 7 · 2017: 8 · 2016: 6 · 2015: 6 · 2014: 9 · 2013: 5 · 2012: 5
- FWCI
- 0.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Microcirculation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bundesministerium für Bildung und Forschung
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- microRNA, endothelial cell apoptosis, myocardial ischemia, retinal vascular development, ischemic heart disease, vascular disease, post-transcriptional regulation
- MeSH terms
- Animals, Cardiovascular Diseases, Cardiovascular Physiological Phenomena, Multigene Family, Humans, Neovascularization, Physiologic, MicroRNAs, Endothelial Cells, Mice
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