The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
THE POPULATION GENETICS OF ADAPTATION: THE DISTRIBUTION OF FACTORS FIXED DURING ADAPTIVE EVOLUTION
Abstract
We know very little about the genetic basis of adaptation. Indeed, we can make no theoretical predictions, however heuristic, about the distribution of phenotypic effects among factors fixed during adaptation nor about the expected "size" of the largest factor fixed. Study of this problem requires taking into account that populations gradually approach a phenotypic optimum during adaptation via the stepwise substitution of favorable mutations. Using Fisher's geometric model of adaptation, I analyze this approach to the optimum, and derive an approximate solution to the size distribution of factors fixed during adaptation. I further generalize these results to allow the input of any distribution of mutational effects. The distribution of factors fixed during adaptation assumes a pleasingly simple, exponential form. This result is remarkably insensitive to changes in the fitness function and in the distribution of mutational effects. An exponential trend among factors fixed appears to be a general property of adaptation toward a fixed optimum.
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Cites
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The Origins of Order: Self-Organization and Selection in Evolution
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The spandrels of San Marco and the Panglossian paradigm: a critique of the adaptationist programme
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The Neutral Theory of Molecular Evolution
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The problems with hybrids: setting conservation guidelines
Allendorf, F. W., Leary, R. F., Spruell, P., & Wenburg, J. K. (2001) · Trends in Ecology & Evolution · doi:10.1016/s0169-5347(01)02290-x · Cited by 1,533
Evolution Experiments with Microorganisms: The Dynamics and Genetic Bases of Adaptation
Elena, S. F., & Lenski, R. E. (2003) · Nature Reviews Genetics · doi:10.1038/nrg1088 · Cited by 1,386
The Genetic Architecture of Quantitative Traits
Mackay, T. F. C. (2001) · Annual Review of Genetics · doi:10.1146/annurev.genet.35.102401.090633 · Cited by 1,106
Understanding quantitative genetic variation
Barton, N. H., & Keightley, P. D. (2002) · Nature Reviews Genetics · doi:10.1038/nrg700 · Cited by 835
Pollinator preference and the evolution of floral traits in monkeyflowers ( Mimulus )
Schemske, D. W., & Bradshaw, H. D. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.21.11910 · Cited by 821
Metadata
- Authors
- Orr, H. A.
- Venue
- Evolution
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-08
- Volume
- 52
- Issue
- 4
- Pages
- 935-949
- ISSN
- 0014-3820 (ISSN-L)
- OpenAlex
- W2004671976
- Cited by
- 893
- References
- 45
- FWCI
- 16.50
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: THE POPULATION GENETICS OF ADAPTATION: THE DISTRIBUTION OF FACTORS FIXED DURING ADAPTIVE EVOLUTION. https://app.cochat.ai/papers/10.1111/j.1558-5646.1998.tb01823.x
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- Orr, H. A. (1998). THE POPULATION GENETICS OF ADAPTATION: THE DISTRIBUTION OF FACTORS FIXED DURING ADAPTIVE EVOLUTION. Evolution. https://doi.org/10.1111/j.1558-5646.1998.tb01823.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
