Cholestatic jaundice associated with the use of metformin

Desilets, David J; Shorr, Andrew F; Moran, Kimberly A; Holtzmuller, Kent C

doi:10.1111/j.1572-0241.2001.03972.x

Cited by 50Drug-Induced Hepatotoxicity and ProtectionLiver Disease Diagnosis and TreatmentLiver physiology and pathology

Cholestatic jaundice associated with the use of metformin

Desilets, David J, Shorr, Andrew F, Moran, Kimberly A, Holtzmuller, Kent C·2001·American Journal of Gastroenterology

DOI 10.1111/j.1572-0241.2001.03972.x

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Abstract

We report a patient who developed cholestatic jaundice shortly after initiation of treatment with metformin hydrochloride. Ultrasound of the liver and abdominal CT were normal. An ERCP showed normal biliary anatomy. A percutaneous liver biopsy was obtained showing marked cholestasis, with portal edema, ductular proliferation, and acute inflammation. Metformin hydrochloride was discontinued, and the patient's jaundice resolved slowly over a period of several months. Given the onset of his jaundice 2 wk after the initiation of metformin, we believe that this case represents an example of metformin-associated hepatotoxicity, the first such case reported.

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Other adverse reactions of metformin are sporadic, such as leucocytoclastic vasculitis, allergic pneumonitis, cholestatic jaundice, and hemolytic anaemia.
“Other adverse reactions are sporadic, such as leucocytoclastic vasculitis, allergic pneumonitis [170], cholestatic jaundice [171], and hemolytic anaemia [172].”
From Metformin: An Old But Still the Best Treatment for Type 2 Diabetes (2013) · cites this paper as [171]

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Authors: Desilets, D. J., Shorr, A. F., Moran, K. A., & Holtzmuller, K. C.
Affiliations: Walter Reed National Military Medical Center (US)
ORCID: Desilets, David J
Shorr, Andrew F
Venue: American Journal of Gastroenterology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2001-07
Volume: 96
Issue: 7
Pages: 2257-2258
ISSN: 0002-9270 (ISSN-L)
1572-0241
DOI: 10.1111/j.1572-0241.2001.03972.x
OpenAlex: W2078064673
Cited by: 50
References: 11
Citations by year: 2023: 2 · 2022: 3 · 2021: 1 · 2020: 1 · 2019: 3 · 2017: 2 · 2016: 5 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 3
FWCI: 1.89
Type: journal article
Language: en
Open access: closed
Locations: The American Journal of Gastroenterology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Keywords: metformin, cholestatic jaundice, drug-induced liver injury, hepatotoxicity, cholestasis, adverse drug reactions, metformin discontinuation
MeSH terms: Cholangiopancreatography, Endoscopic Retrograde, Cholestasis, Humans, Liver Function Tests, Male, Metformin, Middle Aged

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Cholestatic jaundice associated with the use of metformin

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