Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 82

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

Long term effects of phlebotomy on biochemical and histological parameters of chronic hepatitis C

Yano, Motoyoshi, Hayashi, Hisao, Wakusawa, Shinya, Sanae, Fujiko, Takikawa, Toshikuni, Shiono, Yuhta, Arao, Motohiro, Ukai, Koji, Ito, Hiroshi, Watanabe, Kazumasa, Yoshioka, Kentaro·2002·The American Journal of Gastroenterology
DOI 10.1111/j.1572-0241.2002.05436.x
Open this paper in CoChat — free account

Abstract

Objectives There is considerable evidence that iron is a risk factor for liver injury in chronic hepatitis C. Known as iron reduction therapy, phlebotomy reduces serum ALT activity. This effect might continue with maintenance phlebotomy and result in slower progression of liver fibrosis. Methods We examined the biochemical parameters and liver histology of patients with chronic hepatitis C treated by maintenance phlebotomy. For biochemical evaluation, 25 patients were treated by initial phlebotomy to reduce serum ferritin levels to 10 ng/ml or less and then observed for 5 yr with maintenance phlebotomy to maintain the iron-deficient state. For histological evaluation, liver biopsies were performed before and after the study period in 13 of the patients. Thirteen patients who were virological nonresponders to interferon alone and had undergone second liver biopsies after more than 3 yr served as histological controls. Results Serum aminotransferase levels were decreased significantly by initial phlebotomy and remained at the same levels during the study period (p Conclusions These results suggest that phlebotomy with maintenance lowers serum aminotransferase levels, improves liver inflammation, and suppresses the progression of liver fibrosis in chronic hepatitis C.

Overview

Integrity signals

Registry

Crossref · 10.1111/j.1572-0241.2002.05436.x

Cites

29 of 29 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 29 references

Research works printed but not linked: 5

  1. National Institutes of Health, 1997, Hepatology, 26, 2S
  2. Isomura T., 1992, J Clin Electron Microsc, 25, 231
  3. Sartori M., 1998, Ital J Gastroenterol Hepatol, 30, 396
  4. Hayashi H., 1994, Am J Gastroenterol, 89, 986
  5. 10.1016/0270-9139(94)90250-X · DOI

Cited by

Metadata

Authors
Yano, M., Hayashi, H., Wakusawa, S., Sanae, F., Takikawa, T., Shiono, Y., Arao, M., Ukai, K., Ito, H., Watanabe, K., & Yoshioka, K.
Venue
The American Journal of Gastroenterology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2002-01
Volume
97
Issue
1
Pages
133-137
ISSN
  • 0002-9270
  • 1572-0241
DOI
10.1111/j.1572-0241.2002.05436.x
Cited by
82
References
29
Language
en

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.