Role of iron in hepatic fibrosis: One piece in the puzzle

Philippe, Marie A

doi:10.3748/wjg.v13.i35.4746

Cited by 95Liver physiology and pathologyIron Metabolism and DisordersLiver Disease Diagnosis and Treatment

Role of iron in hepatic fibrosis: One piece in the puzzle

Open access

Philippe, Marie A·2007·World Journal of Gastroenterology

DOI 10.3748/wjg.v13.i35.4746PMC PMC4611196

Open this paper in CoChat — free account Open PDF

Abstract

Rieske proteins of the respiratory chain) [1] .Iron is involved in the redox-driven processes of oxygen transport, electron transport and various enzymatic reactions such as DNA synthesis, transcriptional regulation, catalysis as well as nitric oxide (NO) and oxygen sensing [1] .Mammals do not have any major physiological pathway for iron excretion.Therefore, iron uptake and storage is closely regulated so as to avoid deficiency, and excess.In humans, iron deficiency is manifested as anaemia and with increasing severity can eventually result in cardiac failure.Iron overload, especially at sites of storage, enhances oxidative stress ultimately leading to lipid, nucleic acid and protein peroxidation.Within the liver, which is the major site of iron storage, enhanced oxidative stress can lead to fibrosis, cirrhosis, hepatocellular carcinoma (HCC) and death.In this review, we outline the hepatic disease states where iron is an important factor in disease progression.We also discuss the role of iron in promoting liver fibrosis and those cells and mechanisms most important in the underlying wound healing/fibrotic processes. HEPATIC FIBROSISHepatic fibrosis is promoted by various pathogenic, mechanical and toxic insults to the liver, and is part of a physiological wound healing response.If the injurious stimuli are chronic, the degree of fibrosis worsens, leading to cirrhosis, and eventually to hepatic failure and death.The interactions between various resident hepatic cell populations and immune cells that lead to the establishment of fibrosis are complex, and not yet fully understood.However, some profibrogenic pathways and clinical outcomes are common to several disease states, and these will be briefly outlined below.In the nor mal liver, a balance is str uck between extracellular matrix (ECM) deposition and degradation, a process that is tightly regulated by matrix metalloproteinases (MMP) and their specific inhibitors (TIMPs) [2] .Fibrosis is associated with major quantitative and qualitative changes in the ECM.These changes are mainly due to an increase in the expression of TIMP-1 [3] and an increase in the expression of various ECM components, which include fibrillary collagensⅠand Ⅲ, collagen Ⅳ, fibronectin, elastin and laminin [4] .The hepatic stellate cell (HSC) resides within the space of Disse, and is responsible for the majority of ECM deposition in the normal and fibrotic liver [5,6] .In the normal liver the primary role of the HSC is the regulation of �� R��

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3748/wjg.v13.i35.4746

Cites

104 of 104 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

In alcoholic liver disease, both iron and alcohol contribute to the production of hepatic fibrosis.
“Specifically, in alcoholic liver disease, both iron and alcohol contribute to the production of hepatic fibrosis [1352-1358].”
From Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases (2009) · cites this paper as [1357]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Liver fibrosis
Bataller, R., & Brenner, D. A. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24282 · Cited by 4,958 · see citing works
Glutathione Metabolism and Its Implications for Health
Wu, G., Lupton, J. R., Turner, N. D., Fang, Y.-Z., & Yang, S. (2004) · The Journal of Nutrition · doi:10.1093/jn/134.3.489 · Cited by 3,842 · see citing works
Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity.
MATTEONI, C., YOUNOSSI, Z., GRAMLICH, T., BOPARAI, N., LIU, Y., & MCCULLOUGH, A. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70506-8 · Cited by 3,345 · see citing works
Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis
Angulo, P., Keach, J. C., Batts, K., & Lindor, K. (1999) · Hepatology · doi:10.1002/hep.510300604 · Cited by 1,708 · see citing works
Dysmetabolic Hyperferritinemia: All Iron Overload Is Not Hemochromatosis
Makker, J. S., Hanif, A., Bajantri, B., & Chilimuri, S. S. (2015) · Case Reports in Gastroenterology · doi:10.1159/000373883 · Cited by 1,353 · see citing works
Iron metabolism and toxicity
Papanikolaou, G., & Pantopoulos, K. (2005) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2004.06.021 · Cited by 1,070 · see citing works
Survival and Causes of Death in Cirrhotic and in Noncirrhotic Patients with Primary Hemochromatosis
Niederau, C., Fischer, R., Sonnenberg, A., Stremmel, W., Trampisch, H. J., & Strohmeyer, G. W. (1985) · New England Journal of Medicine · doi:10.1056/nejm198511143132004 · Cited by 1,063 · see citing works
Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein
Okuda, M., Li, K., Beard, M. R., Showalter, L. A., Scholle, F., Lemon, S. M., & Weinman, S. A. (2002) · Gastroenterology · doi:10.1053/gast.2002.30983 · Cited by 926 · see citing works
Oxidative stress-related molecules and liver fibrosis
Parola, M., & Robino, G. (2001) · Journal of Hepatology · doi:10.1016/s0168-8278(01)00142-8 · Cited by 781 · see citing works
Value of Hepatic Iron Measurements in Early Hemochromatosis and Determination of the Critical Iron Level Associated With Fibrosis
Bassett, M. L., Halliday, J. W., & Powell, L. W. (1986) · Hepatology · doi:10.1002/hep.1840060106 · Cited by 673 · see citing works
Increased hepatic iron concentration in nonalcoholic steatohepatitis is associated with increased fibrosis
George, D. K., Goldwurm, S., Macdonald, G. A., Cowley, L. L., Walker, N. I., Ward, P. J., Jazwinska, E. C., & Powell, L. W. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70482-2 · Cited by 655 · see citing works
Experimental liver cirrhosis induced by alcohol and iron.
Tsukamoto, H., Horne, W., Kamimura, S., Niemelä, O. J., Parkkila, S., Ylä‐Herttuala, S., & Brittenham, G. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118077 · Cited by 512 · see citing works
Insulin resistance–associated hepatic iron overload
Mendler, M.-H., Turlin, B., Moirand, R., Jouanolle, A., Sapey, T., Guyader, D., Gall, J. L., Brissot, P., David, V., & Deugnier, Y. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70401-4 · Cited by 493 · see citing works
Tumour necrosis factor α signalling through activation of Kupffer cells plays an essential role in liver fibrosis of non-alcoholic steatohepatitis in mice
Tomita, K., Tamiya, G., Ando, S., Ohsumi, K., Chiyo, T., Mizutani, A., Kitamura, N., Toda, K., Kaneko, T., Horie, Y., et al. (2005) · Gut · doi:10.1136/gut.2005.071118 · Cited by 439 · see citing works
Change in the prevalence of overweight and obesity among young Australians, 1969–1997
Booth, M. L., Chey, T., Wake, M. A., Norton, K. I., Hesketh, K. D., Dollman, J., & Robertson, I. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.1.29 · Cited by 439 · see citing works
Activation of cultured rat hepatic lipocytes by Kupffer cell conditioned medium. Direct enhancement of matrix synthesis and stimulation of cell proliferation via induction of platelet-derived growth factor receptors.
Friedman, S. L., & Arthur, M. J. P. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114362 · Cited by 404 · see citing works
Measurements of iron status in patients with chronic hepatitis
Bisceglie, A. M. D., Axiotis, C. A., Hoofnagle, J. H., & Bacon, B. R. (1992) · Gastroenterology · doi:10.1016/0016-5085(92)90339-z · Cited by 388 · see citing works
Risk factors of fibrosis in alcohol-induced liver disease
Raynard, B., Balian, A., Fallik, D., Capron, F., Bédossa, P., Chaput, J., & Naveau, S. (2002) · Hepatology · doi:10.1053/jhep.2002.31782 · Cited by 387 · see citing works
Non-alcoholic steatohepatitis and iron: increased prevalence of mutations of the HFE gene in non-alcoholic steatohepatitis.
Bonkovsky, H., Jawaid, Q., Tortorelli, K., LeClair, P., Cobb, J., Lambrecht, R., & Banner, B. (1999) · Journal of Hepatology · doi:10.1016/s0168-8278(99)80032-4 · Cited by 357 · see citing works
Hepatic Stellate Cell Behavior during Resolution of Liver Injury
Iredale, J. P. (2001) · Seminars in Liver Disease · doi:10.1055/s-2001-17557 · Cited by 333 · see citing works
Immunochemical detection of 4-hydroxynonenal protein adducts in oxidized hepatocytes.
Uchida, K., Szweda, L. I., Chae, H. Z., & Stadtman, E. R. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.18.8742 · Cited by 332 · see citing works
Hepatic steatosis in obese patients: clinical aspects and prognostic significance
Festi, D., Colecchia, A., Sacco, T., Bondi, M., Roda, E., & Marchesini, G. (2004) · Obesity Reviews · doi:10.1111/j.1467-789x.2004.00126.x · Cited by 312 · see citing works
Liver pathology in genetic hemochromatosis: A review of 135 homozygous cases and their bioclinical correlations
Deugnier, Y., Loréal, O., Turlin, B., Guyader, D., Jouanolle, H., Moirand, R., Jacquelinet, C., & Brissot, P. (1992) · Gastroenterology · doi:10.1016/0016-5085(92)90331-r · Cited by 310 · see citing works
Hepatic Stellate Cells: Unique Characteristics in Cell Biology and Phenotype
Sato, M., Suzuki, S., & Senoo, H. (2003) · Cell Structure and Function · doi:10.1247/csf.28.105 · Cited by 292 · see citing works
Phagocytosis of apoptotic bodies by hepatic stellate cells induces NADPH oxidase and is associated with liver fibrosis in vivo
Zhan, S.-S., Jiang, J. X., Wu, J., Halsted, C., Friedman, S. L., Zern, M. A., & Torok, N. J. (2006) · Hepatology · doi:10.1002/hep.21093 · Cited by 284 · see citing works
Oxidative stress and lipid peroxidation-derived DNA-lesions in inflammation driven carcinogenesis
Bartsch, H., & Nair, J. (2004) · Cancer Detection and Prevention · doi:10.1016/j.cdp.2004.07.004 · Cited by 276 · see citing works
Redox Regulation of the Caspases during Apoptosisa
Hampton, M. B., Fadeel, B., & Orrenius, S. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09913.x · Cited by 274 · see citing works
Hepatic iron concentration as a predictor of response to interferon alfa therapy in chronic hepatitis C
Olynyk, J. K., Reddy, K. R., Bisceglie, A. M. D., Jeffers, L. J., Parker, T., Radick, J. L., Schiff, E. R., & Bacon, B. R. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90209-0 · Cited by 252 · see citing works
Stimulation of collagen α1(I) gene expression is associated with lipid peroxidation in hepatocellular injury: A link to tissue fibrosis?,
Bédossa, P., Houglum, K., Trautwein, C., Holstege, A., & Chojkier, M. (1994) · Hepatology · doi:10.1002/hep.1840190527 · Cited by 248 · see citing works
Reversibility of hepatic fibrosis in treated genetic hemochromatosis: A study of 36 cases
Falize, L., Guillygomarc’h, A., Perrin, M., Lainé, F., Guyader, D., Brissot, P., Turlin, B., & Deugnier, Y. (2006) · Hepatology · doi:10.1002/hep.21260 · Cited by 245 · see citing works
Hepatic iron and nonalcoholic fatty liver disease
Younossi, Z. M., Gramlich, T., Bacon, B. R., Matteoni, C. A., Boparai, N., O’Neill, R., & McCullough, A. J. (1999) · Hepatology · doi:10.1002/hep.510300407 · Cited by 236 · see citing works
Effect of iron depletion in carbohydrate-intolerant patients with clinical evidence of nonalcoholic fatty liver disease
Facchini, F. S., Hua, N. W., & Stoohs, R. A. (2002) · Gastroenterology · doi:10.1053/gast.2002.32403 · Cited by 233 · see citing works
Oxidative-stress and IL-6 mediate the fibrogenic effects of rodent Kupffer cells on stellate cells
Nieto, N. (2006) · Hepatology · doi:10.1002/hep.21427 · Cited by 227 · see citing works
Hepatotoxicity of Iron Overload: Mechanisms of Iron-Induced Hepatic Fibrogenesis
Ramm, G. A., & Ruddell, R. G. (2005) · Seminars in Liver Disease · doi:10.1055/s-2005-923315 · Cited by 221 · see citing works
Role of malondialdehyde-acetaldehyde adducts in liver injury1,2 1Guest editor: Arthur Cederbaum 2This article is part of a series of reviews on “Alcohol, Oxidative Stress and Cell Injury.” The full list of papers may be found on the homepage of the journal.
Tuma, D. J. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00742-0 · Cited by 211 · see citing works
Cytochrome P450 2E1-derived Reactive Oxygen Species Mediate Paracrine Stimulation of Collagen I Protein Synthesis by Hepatic Stellate Cells
Nieto, N., Friedman, S. L., & Cederbaum, A. I. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110506200 · Cited by 208 · see citing works
Hepatic iron stores and markers of iron overload in alcoholics and patients with idiopathic hemochromatosis
Chapman, R. W., Morgan, M. Y., Laulicht, M., Hoffbrand, A. V., & Sherlock, S. (1982) · Digestive Diseases and Sciences · doi:10.1007/bf01316575 · Cited by 203 · see citing works
Screening for Hemochromatosis in Asymptomatic Subjects With or Without a Family History
Powell, L. W., Dixon, J. L., Ramm, G. A., Purdie, D. M., Lincoln, D. J., Anderson, G. J., Subramaniam, V. N., Hewett, D. G., Searle, J. W., Fletcher, L. M., et al. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.3.294 · Cited by 199 · see citing works
A Role for Serotonin (5-HT) in Hepatic Stellate Cell Function and Liver Fibrosis
Ruddell, R. G., Oakley, F., Hussain, Z., Yeung, I., Bryan‐Lluka, L. J., Ramm, G. A., & Mann, D. A. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.050767 · Cited by 195 · see citing works
CYP2E1-mediated oxidative stress induces collagen type I expression in rat hepatic stellate cells
Nieto, N., Friedman, S. L., Greenwel, P., & Cederbaum, A. I. (1999) · Hepatology · doi:10.1002/hep.510300433 · Cited by 181 · see citing works
Steatosis Is a Cofactor in Liver Injury in Hemochromatosis
Powell, E. E., Ali, A., Clouston, A. D., Dixon, J. L., Lincoln, D. J., Purdie, D. M., Fletcher, L. M., Powell, L. W., & Jonsson, J. R. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.09.015 · Cited by 172 · see citing works
Pathogenesis of Liver Fibrosis
Alcolado, R., Arthur, M. J. P., & Iredale, J. P. (1997) · Clinical Science · doi:10.1042/cs0920103 · Cited by 172 · see citing works
Hepatic Iron Overload Induces Hepatocellular Carcinoma in Transgenic Mice Expressing the Hepatitis C Virus Polyprotein
Furutani, T., Hino, K., Okuda, M., Gondo, T., Nishina, S., Kitase, A., Korenaga, M., Xiao, S., Weinman, S. A., Lemon, S. M., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.02.060 · Cited by 169 · see citing works
Hepcidin Is Down‐regulated in Alcoholic Liver Injury: Implications for the Pathogenesis of Alcoholic Liver Disease
Bridle, K. R., Cheung, T., Murphy, T. L., Walters, M. M., Anderson, G. J., Crawford, D. H., & Fletcher, L. M. (2006) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00002.x · Cited by 165 · see citing works
Iron reduction before and during interferon therapy of chronic hepatitis C: Results of a multicenter, randomized, controlled trial
Fontana, R. J., Israel, J., LeClair, P., Banner, B. F., Tortorelli, K., Grace, N. D., Levine, R. A., Fiarman, G. S., Thiim, M., Tavill, A. S., et al. (2000) · Hepatology · doi:10.1002/hep.510310325 · Cited by 165 · see citing works
Transforming growth factor β and tumor necrosis factor α inhibit both apoptosis and proliferation of activated rat hepatic stellate cells
Saile, B., Matthes, N., Knittel, T. E., & Ramadori, G. P. (1999) · Hepatology · doi:10.1002/hep.510300144 · Cited by 158 · see citing works
Oxidative stress-mediated hepatotoxicity of iron and copper: Role of Kupffer cells
Videla, L. A., Fernández, V., Tapia, G., & Varela, P. (2003) · BioMetals · doi:10.1023/a:1020707811707 · Cited by 140 · see citing works
Liver iron is predictive of death in alcoholic cirrhosis: a multivariate study of 229 consecutive patients with alcoholic and/or hepatitis C virus cirrhosis: a prospective follow up study
Ganne‐Carrié, N., Christidis, C., Chastang, C., Ziol, M., Chapel, F., Imbert‐Bismut, F., Trinchet, J., Guettier, C., & Beaugrand, M. (2000) · Gut · doi:10.1136/gut.46.2.277 · Cited by 137 · see citing works
Role of iron in NF-kappa B activation and cytokine gene expression by rat hepatic macrophages
Lin, M., Rippe, R. A., Niemelä, O. J., Brittenham, G. M., & Tsukamoto, H. (1997) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1997.272.6.g1355 · Cited by 133 · see citing works
Iron in Nonhemochromatotic Liver Disorders
Alla, V., & Bonkovsky, H. L. (2005) · Seminars in Liver Disease · doi:10.1055/s-2005-923317 · Cited by 124 · see citing works
Iron primes hepatic macrophages for NF-κB activation in alcoholic liver injury
Tsukamoto, H., Lin, M., Ohata, M., Giulivi, C., French, S. W., & Brittenham, G. M. (1999) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1999.277.6.g1240 · Cited by 121 · see citing works
Iron stores, response to α‐interferon therapy, and effects of iron depletion in chronic hepatitis C
Piperno, A., Sampietro, M., D’Alba, R., Roffi, L., Fargion, S. R., Parma, S., Nicoli, C., Corbetta, N., Pozzi, M., Arosio, V., et al. (1996) · Liver International · doi:10.1111/j.1600-0676.1996.tb00737.x · Cited by 116 · see citing works
Hepatic stellate cell activation in genetic haemochromatosis
Ramm, G. A., Crawford, D. H., Powell, L. W., Walker, N. I., Fletcher, L. M., & Halliday, J. W. (1997) · Journal of Hepatology · doi:10.1016/s0168-8278(97)80424-2 · Cited by 113 · see citing works
Induction and Regulation of Hepatocyte Apoptosis by Oxidative Stress
Czaja, M. J. (2002) · Antioxidants and Redox Signaling · doi:10.1089/152308602760598909 · Cited by 113 · see citing works
Long term effects of phlebotomy on biochemical and histological parameters of chronic hepatitis C
Yano, M., Hayashi, H., Wakusawa, S., Sanae, F., Takikawa, T., Shiono, Y., Arao, M., Ukai, K., Ito, H., Watanabe, K., et al. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05436.x · Cited by 112 · see citing works
Hemochromatosis and alcoholic liver disease
Fletcher, L. M., & Powell, L. W. (2003) · Alcohol · doi:10.1016/s0741-8329(03)00128-9 · Cited by 104 · see citing works
Pathophysiology of Iron Toxicity
Britton, R. S., Ramm, G. A., Olynyk, J. K., Singh, R., O’Neill, R., & Bacon, B. R. (1994) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-2554-7_26 · Cited by 102 · see citing works
Effect of Nitric Oxide on Iron–Mediated Oxidative Stress in Primary Rat Hepatocyte Culture
Sergent, O., Griffon, B., Morel, I., Chevanne, M., Dubos, M., Cillard, P., & Cillard, J. (1997) · Hepatology · doi:10.1002/hep.510250123 · Cited by 101 · see citing works
Oxidative stress mediated toxicity exerted by ethanol-inducible CYP2E1
Wu, D. T. S., & Cederbaum, A. I. (2005) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2005.01.057 · Cited by 98 · see citing works
Oxidative stress inhibits IFN-α-induced antiviral gene expression by blocking the JAK–STAT pathway
Bona, D. D., Cippitelli, M., Fionda, C., Cammà, C., Licata, A., Santoni, A., & Craxı̀, A. (2006) · Journal of Hepatology · doi:10.1016/j.jhep.2006.01.037 · Cited by 96 · see citing works
Intracellular survival pathways in the liver
Luedde, T., & Trautwein, C. (2006) · Liver International · doi:10.1111/j.1478-3231.2006.01366.x · Cited by 95 · see citing works
Effect of free iron on collagen synthesis, cell proliferation and MMP-2 expression in rat hepatic stellate cells
Gardi, C., Arezzini, B., Fortino, V., & Comporti, M. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(02)01257-1 · Cited by 94 · see citing works
Causes and consequences of mitochondrial reactive oxygen species generation in hepatitis C
Wang, T., & Weinman, S. A. (2006) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2006.04591.x · Cited by 93 · see citing works
Liver Fibrosis and Altered Matrix Synthesis
Neubauer, K., Saile, B., & Ramadori, G. P. (2001) · Canadian Journal of Gastroenterology · doi:10.1155/2001/870205 · Cited by 87 · see citing works
Relationship between hepatic iron deposits and response to interferon in chronic hepatitis C.
Ikura, Y., Morimoto, H., Johmura, H., Fukui, M., & Sakurai, M. (1996) · PubMed · Cited by 85 · see citing works
Liver hepcidin mRNA correlates with iron stores, but not inflammation, in patients with chronic hepatitis C.
Aoki, C. A., Rossaro, L., Ramsamooj, R., Brandhagen, D. J., Burritt, M. F., & Bowlus, C. L. (2005) · PubMed · Cited by 75 · see citing works
Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein
Lemon, S. M., Scholle, F., Weinman, S. A., et al. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/94t6-9036 · Cited by 74 · see citing works
Liver iron is a surrogate marker of severe fibrosis in chronic hepatitis C
Guyader, D., de Lajarte‐Thirouard, A., Erdtmann, L., Rakba, N., Jacquelinet, S., Danielou, H., Perrin, M., Jouanolle, A., Brissot, P., & Deugnier, Y. (2006) · Journal of Hepatology · doi:10.1016/j.jhep.2006.09.021 · Cited by 73 · see citing works
Liver damage in Italian patients with hereditary hemochromatosis is highly influenced by hepatitis B and C virus infection
Piperno, A., Fargion, S. R., D’Alba, R., Roffi, L., Fracanzani, A. L., Vecchi, L., Failla, M., & Fiorelli, G. (1992) · Journal of Hepatology · doi:10.1016/s0168-8278(05)80671-3 · Cited by 73 · see citing works
Regulatory failure of serum prohepcidin levels in patients with hepatitis C
NAGASHIMA, M., Kudo, M., CHUNG, H., ISHIKAWA, E., HAGIWARA, S., Nakatani, T., & Dote, K. (2006) · Hepatology Research · doi:10.1016/j.hepres.2006.08.006 · Cited by 69 · see citing works
Cytochrome P4502E1 primes macrophages to increase TNF-α production in response to lipopolysaccharide
Cao, Q., Mak, K. M., & Lieber, C. S. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00383.2004 · Cited by 64 · see citing works
Regulation of platelet-derived growth factor secretion and gene expression in human liver fat-storing cells
Marra, F., Choudhury, G. G., Pinzani, M., & Abboud, H. E. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90236-4 · Cited by 63 · see citing works
Identification and characterization of a receptor for tissue ferritin on activated rat lipocytes.
Ramm, G. A., Britton, R. S., O’Neill, R., & Bacon, B. R. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117353 · Cited by 60 · see citing works
Changes in serum iron levels due to infection with hepatitis B virus
Blumberg, B. S., Lustbader, E. D., & Whitford, P. L. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.5.3222 · Cited by 60 · see citing works
THE NATURAL HISTORY OF CHRONIC HEPATITIS C VIRUS INFECTION
Seeff, L. B. (1997) · Clinics in Liver Disease · doi:10.1016/s1089-3261(05)70323-8 · Cited by 56 · see citing works
Hepatic stellate cells in hepatitis C patients: Relationship with liver iron deposits and severity of liver disease
Martinelli, A. L. C., Ramalho, L. N. Z., & Zucoloto, S. (2003) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2004.03255.x · Cited by 56 · see citing works
Effect of iron depletion on long-term response to interferon-alpha in patients with chronic hepatitis C who previously did not respond to interferon therapy.
Tsai, N., Zuckerman, E., Han, S. H., Goad, K., Redeker, A. G., & Fong, T. (1997) · PubMed · Cited by 56 · see citing works
Iron chelators and iron toxicity
Brittenham, G. M. (2003) · Alcohol · doi:10.1016/s0741-8329(03)00101-0 · Cited by 54 · see citing works
Spur cell anaemia and hepatic iron stores in patients with alcoholic liver disease undergoing orthotopic liver transplantation
Pascoe, A., Kerlin, P., Steadman, C. J., Clouston, A. D., Jones, D., Powell, L. W., Jazwinska, E. C., Lynch, S. V., & Strong, R. W. (1999) · Gut · doi:10.1136/gut.45.2.301 · Cited by 52 · see citing works
Regulation of Tissue Inhibitor of Metalloproteinase 1 Gene Transcription by RUNX1 and RUNX2
Bertrand-Philippe, M., Ruddell, R. G., Arthur, M. J. P., Thomas, J., Mungalsingh, N., & Mann, D. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311804200 · Cited by 49 · see citing works
Is There A Threshold of Hepatic Iron Concentration That Leads To Cirrhosis in C282y Hemochromatosis?
Adams, P. C. (2001) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2001.03472.x · Cited by 48 · see citing works
Identification and Characterization of the Hepatic Stellate Cell Transferrin Receptor
Bridle, K. R., Crawford, D. H., & Ramm, G. A. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64300-3 · Cited by 46 · see citing works
The Chemistry and Biological Effects of Malondialdehyde‐Acetaldehyde Adducts
Thiele, G. M., Worrall, S., Tuma, D. J., Klassen, L. W., Wyatt, T. A., & Nagata, N. (2001) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2001.tb02399.x · Cited by 46 · see citing works
Malondialdehyde–acetaldehyde–protein adducts increase secretion of chemokines by rat hepatic stellate cells
Kharbanda, K. K., Todero, S. L., Shubert, K. A., Sorrell, M. F., & Tuma, D. J. (2001) · Alcohol · doi:10.1016/s0741-8329(01)00174-4 · Cited by 45 · see citing works
Iron, hepatic stellate cells and fibrosis in chronic hepatitis C
Rigamonti, C., Andorno, S., Maduli, E., Morelli, S., Pittau, S., Nicosia, G., Boldorini, R. L., & Sartori, M. G. F. (2002) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2002.0320s1028.x · Cited by 45 · see citing works
Spur cell anemia and hepatic iron stores in patients with alcoholic liver disease undergoing orthotopic liver transplantation
Pascoe, A., Kerlin, P., Steadman, C. J., Clouston, A. D., Powell, L. W., Jazwinska, E. C., Lynch, S. V., & Strong, R. W. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)85357-2 · Cited by 43 · see citing works
Hepatic iron deposition in human disease and animal models
Halliday, J., & Searle, J. W. (1996) · BioMetals · doi:10.1007/bf00144626 · Cited by 40 · see citing works
Corn oil rapidly activates nuclear factor-κB in hepatic Kupffer cells by oxidant-dependent mechanisms
Rusyn, I., Bradham, C. A., Cohn, L., Schoonhoven, R., Swenberg, J. A., Brenner, D. A., & Thurman, R. G. (1999) · Carcinogenesis · doi:10.1093/carcin/20.11.2095 · Cited by 39 · see citing works
Manipulation of glutathione stores in rat hepatic stellate cells does not alter collagen synthesis
Maher, J. J., & Neuschwander‐Tetri, B. A. (1997) · Hepatology · doi:10.1002/hep.510260313 · Cited by 38 · see citing works
Hepatic stellate cells are not subjected to oxidant stress during iron-induced fibrogenesis in rodents
Montosi, G., Garuti, C., Martinelli, S., & Pietrangelo, A. (1998) · Hepatology · doi:10.1002/hep.510270622 · Cited by 34 · see citing works
Ethanol Induces Transforming Growth Factor‐α Expression in Hepatocytes, Leading to Stimulation of Collagen Synthesis by Hepatic Stellate Cells
Kato, J., Sato, Y., Inui, N., Nakano, Y., Takimoto, R., Takada, K., Kobune, M., Kuroiwa, G., Miyake, S., Kohgo, Y., et al. (2003) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000078614.44983.97 · Cited by 31 · see citing works
The Emerging Role of the Liver in Iron Metabolism
Sharma, N., Butterworth, J. R., Cooper, B. T., Tselepis, C., & Iqbal, T. H. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.40152.x · Cited by 28 · see citing works
Effect of malondialdehyde–acetaldehyde–protein adducts on the protein kinase C-dependent secretion of urokinase-type plasminogen activator in hepatic stellate cells
Kharbanda, K. K., Shubert, K. A., Wyatt, T. A., Sorrell, M. F., & Tuma, D. J. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(01)00883-8 · Cited by 28 · see citing works
HCV core protein localizes in the nuclei of nonparenchymal liver cells from chronically HCV-infected patients
Falcón, V., Acosta‐Rivero, N., Shibayama, M., Chinea, G., Gavilondo, J., de la Rosa, M. C., Menéndez, I., Grá, B., Dueñas‐Carrera, S., Vina-Rodrı́guez, A., et al. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.02.107 · Cited by 24 · see citing works
Hepatitis C virus infection in patients with idiopathic hemochromatosis (IH) and porphyria cutanea tarda (PCT)
Piperno, A., D’Alba, R., Roffi, L., Pozzi, M. R., Farina, A., Vecchi, L., & Fiorelli, G. (1992) · Archives of virology. Supplementum · doi:10.1007/978-3-7091-5633-9_46 · Cited by 22 · see citing works
Aldehydic products of lipid peroxidation do not directly activate rat hepatic stellate cells
Olynyk, J. K., Khan, N., Ramm, G. A., Brown, K. E., O’Neill, R., Britton, R. S., & Bacon, B. R. (2002) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.2002.02798.x · Cited by 22 · see citing works
Modulation of stellate cell proliferation and gene expression by rat hepatocytes: effect of toxic iron overload
Parkes, J. G. (2003) · Toxicology Letters · doi:10.1016/s0378-4274(03)00222-4 · Cited by 19 · see citing works
Iron reduction therapy by phlebotomy reduces lipid peroxidation and oxidative stress in patients with chronic hepatitis C
Kaito, M., Iwasa, M., Kobayashi, Y., Fujita, N., Tanaka, H., Gabazza, E. C., Adachi, Y., Kojima, Y., Nakagawa, N., & Watanabe, S. (2006) · Journal of Gastroenterology · doi:10.1007/s00535-006-1871-5 · Cited by 18 · see citing works
The Chemistry and Biological Effects of Malondialdehyde-Acetaldehyde Adducts
Thiele, G. M., Worrall, S., Tuma, D. J., Klassen, L. W., Wyatt, T. A., & Nagata, N. (2001) · Alcoholism Clinical and Experimental Research · doi:10.1097/00000374-200105051-00035 · Cited by 12 · see citing works
Rat liver ferritin selectively inhibits expression of alpha-smooth muscle actin in cultured rat lipocytes
Ramm, G. A., Britton, R. S., O’Neill, R., Kohn, H. D., & Bacon, B. R. (1996) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1996.270.2.g370 · Cited by 11 · see citing works
Effect of nitric oxide on iron-mediated oxidative stress in primary rat hepatocyte culture
Sergent, O. (1997) · Hepatology · doi:10.1053/jhep.1997.v25.pm0008985277 · Cited by 11 · see citing works
Optimal duration of therapy in HBV-related cirrhosis
Lim, C. Y., & Kowdley, K. V. (2007) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkm102 · Cited by 8 · see citing works
Manipulation of glutathione stores in rat hepatic stellate cells does not alter collagen synthesis
Maher, J. J. (1997) · Hepatology · doi:10.1053/jhep.1997.v26.pm0009303491 · Cited by 4 · see citing works
Is there a threshold of hepatic iron concentration that leads to cirrhosis in C282Y hemochromatosis?
Adams, P. C. (2001) · The American Journal of Gastroenterology · doi:10.1016/s0002-9270(00)02265-6 · Cited by 4 · see citing works

Flagged first, then by citations

Research works printed but not linked: 3

Yano M, Hayashi H, Wakusawa S, Sanae F, Takikawa T, Shiono Y, Arao M, Ukai K, Ito H, Watanabe K, Yoshioka K . L o n g t e r m e f f e c t s o f p h l e b o t o m y o n b i o c h e m i c a l and histological parameters of chronic hepatitis C. Am J Gastroenterol 2002; 97: 133-137
Tuma DJ. Role of malondialdehyde-acetaldehyde adducts in liver injury. Free Radic Biol Med 2002; 32: 303-308
Ruddell RG, Rutherford PS, Barwood JM, Hoang-Le D, Santambrogio P, Arosio P, Ramm GA. Ferritin upregulates the expression of NF-κB-dependant genes associated with hepatic stellate cell activation via PI3-kinase, PKCζ and MAPK. Hepatology 2004; 40: A269 88

Sorted by citations

Alcoholic liver disease: mechanisms of injury and targeted treatment
Louvet, A., & Mathurin, P. (2015) · Nature Reviews Gastroenterology &Hepatology · doi:10.1038/nrgastro.2015.35 · Cited by 820 · see citing works
Diagnosis and management of hemochromatosis: 2011 Practice Guideline by the American Association for the Study of Liver Diseases
Bacon, B. R., Adams, P. C., Kowdley, K. V., Powell, L. W., & Tavill, A. S. (2011) · Hepatology · doi:10.1002/hep.24330 · Cited by 721 · see citing works
Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases
Kell, D. B. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-2 · Cited by 554 · see citing works
Mechanisms of liver fibrosis and its role in liver cancer
Dhar, D., Baglieri, J., Kisseleva, T., & Brenner, D. A. (2020) · Experimental Biology and Medicine · doi:10.1177/1535370219898141 · Cited by 440 · see citing works
Redox mechanisms in hepatic chronic wound healing and fibrogenesis
Novo, E., & Parola, M. (2008) · Fibrogenesis & Tissue Repair · doi:10.1186/1755-1536-1-5 · Cited by 406 · see citing works
Ferritin functions as a proinflammatory cytokine via iron‐independent protein kinase C zeta/nuclear factor kappaB–regulated signaling in rat hepatic stellate cells†
Ruddell, R. G., Hoang‐Le, D., Barwood, J. M., Rutherford, P. S., Piva, T. J., Watters, D. J., Santambrogio, P., Arosio, P., & Ramm, G. A. (2009) · Hepatology · doi:10.1002/hep.22716 · Cited by 298 · see citing works
Iron and liver fibrosis: Mechanistic and clinical aspects
Mehta, K. J., Farnaud, S., & Sharp, P. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i5.521 · Cited by 271 · see citing works
Effect of Coffee and Green Tea Consumption on the Risk of Liver Cancer: Cohort Analysis by Hepatitis Virus Infection Status
Inoue, M., Kurahashi, N., Iwasaki, M., Shimazu, T., Tanaka, Y., Mizokami, M., & Tsugane, S. (2009) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-08-0923 · Cited by 114 · see citing works
Decompose quantitative susceptibility mapping (QSM) to sub-voxel diamagnetic and paramagnetic components based on gradient-echo MRI data
Chen, J., Gong, N., Chaim, K. T., Otaduy, M. C. G., & Liu, C. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.118477 · Cited by 111 · see citing works
Diagnostik und Therapie des hepatozellulären Karzinoms
Greten, T. F., Malek, N. P., Schmidt, S., Arends, J., Bartenstein, P., Bechstein, W. O., Bernatik, T., Bitzer, M., Chavan, A., Dollinger, M. M., et al. (2013) · Zeitschrift für Gastroenterologie · doi:10.1055/s-0033-1355841 · Cited by 101 · see citing works
Hereditary hemochromatosis in the post- HFE era
Olynyk, J. K., Trinder, D., Ramm, G. A., Britton, R. S., & Bacon, B. R. (2008) · Hepatology · doi:10.1002/hep.22507 · Cited by 95 · see citing works
Iron mediated hematological, oxidative and histological alterations in freshwater fish Labeo rohita
Singh, M., Barman, A. S., Devi, A. L., Devi, A. G., & Pandey, P. K. (2018) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2018.11.129 · Cited by 92 · see citing works
Hepatic iron loading in mice increases cholesterol biosynthesis†
Graham, R. M., Chua, A. C. G., Carter, K. W., Delima, R. D., Johnstone, D. M., Herbison, C. E., Firth, M. J., O’Leary, R., Milward, E. A., Olynyk, J. K., et al. (2010) · Hepatology · doi:10.1002/hep.23712 · Cited by 88 · see citing works
Iron: An emerging factor in colorectal carcinogenesis
Chua, A. C. G. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i6.663 · Cited by 77 · see citing works
Novel Bioimaging Techniques of Metals by Laser Ablation Inductively Coupled Plasma Mass Spectrometry for Diagnosis Of Fibrotic and Cirrhotic Liver Disorders
M‐M, P., Weiskirchen, R., Gaßler, N., Bosserhoff, A., & Becker, J. S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058702 · Cited by 72 · see citing works
Epigallocatechin Gallate Protects Mice against Methionine–Choline-Deficient-Diet-Induced Nonalcoholic Steatohepatitis by Improving Gut Microbiota To Attenuate Hepatic Injury and Regulate Metabolism
Ning, K., Lu, K., Chen, Q., Guo, Z., Du, X., Riaz, F., Feng, L., Fu, Y., Yin, C., Zhang, F., et al. (2020) · ACS Omega · doi:10.1021/acsomega.0c01689 · Cited by 70 · see citing works
Diagnosis and Management of Hereditary Hemochromatosis
Salgia, R. J., & Brown, K. (2014) · Clinics in Liver Disease · doi:10.1016/j.cld.2014.09.011 · Cited by 74 · see citing works
Inositol hexa phosphoric acid (phytic acid), a nutraceuticals, attenuates iron-induced oxidative stress and alleviates liver injury in iron overloaded mice
Bhowmik, A., Ojha, D., Goswami, D., Das, R., Chandra, N. S., Chatterjee, T. K., Chakravarty, A., Chakravarty, S., & Chattopadhyay, D. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.12.125 · Cited by 53 · see citing works
Pathogenesis of the systemic inflammatory syndrome and acute lung injury: role of iron mobilization and decompartmentalization
Lagan, A. L., Melley, D. D., Evans, T. W., & Quinlan, G. J. (2007) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00169.2007 · Cited by 52 · see citing works
Liver Iron Loading in Alcohol-Associated Liver Disease
Ali, N., Ferrao, K., & Mehta, K. J. (2022) · American Journal Of Pathology · doi:10.1016/j.ajpath.2022.08.010 · Cited by 49 · see citing works
Multitargeted inhibition of hepatic fibrosis in chronic iron-overloaded mice by Salvia miltiorrhiza
Zhang, Y., Zhang, Y., Xie, Y., Gao, Y., Ma, J., Yuan, J., Li, J., Wang, J., Li, L., Zhang, J., et al. (2013) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2013.05.028 · Cited by 47 · see citing works
Iron Enhances Hepatic Fibrogenesis and Activates Transforming Growth Factor-β Signaling in Murine Hepatic Stellate Cells
Mehta, K. J., Coombes, J. D., Briones-Orta, M. A., Manka, P. P., Williams, R. L., Patel, V. B., & Syn, W. (2017) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2017.08.012 · Cited by 44 · see citing works
Non-alcoholic fatty liver disease: is iron relevant?
O’Brien, J., & Powell, L. W. (2011) · Hepatology International · doi:10.1007/s12072-011-9304-9 · Cited by 42 · see citing works
Current understanding of the metabolism of micronutrients in chronic alcoholic liver disease
Wu, J., & Meng, Q. (2020) · World Journal of Gastroenterology · doi:10.3748/wjg.v26.i31.4567 · Cited by 44 · see citing works
Elevated free cholesterol in a p62 overexpression model of non-alcoholic steatohepatitis
Simon, Y., Kessler, S. M., Gemperlein, K., Bohle, R. M., Müller, R., Haybaeck, J., & Kiemer, A. K. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i47.17839 · Cited by 41 · see citing works
Dietary Iron Supplementation Alters Hepatic Inflammation in a Rat Model of Nonalcoholic Steatohepatitis
Atarashi, M., Izawa, T., Miyagi, R., Ohji, S., Hashimoto, A., Kuwamura, M., & Yamate, J. (2018) · Nutrients · doi:10.3390/nu10020175 · Cited by 38 · see citing works
Iron as a therapeutic target in chronic liver disease
Kouroumalis, E., Tsomidis, I., & Voumvouraki, A. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i4.616 · Cited by 40 · see citing works
High Carbohydrate High Fat Diet Induced Hepatic Steatosis and Dyslipidemia Were Ameliorated by<i>Psidium guajava</i>Leaf Powder Supplementation in Rats
Mamun, M. A. A., Faruk, M., Rahman, M. M., Nahar, K., Kabir, F., Alam, M. A., & Subhan, N. (2019) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2019/1897237 · Cited by 34 · see citing works
Deferoxamine alleviates liver fibrosis induced by CC l4 in rats
Mohammed, A., Haleem, E. N. A. A., El‐Bakly, W. M., & El‐Demerdash, E. (2016) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12591 · Cited by 34 · see citing works
QSM Throughout the Body
Dimov, A., Li, J., Nguyen, T. D., Roberts, A., Spincemaille, P., Straub, S., Zun, Z., Prince, M. R., & Wang, Y. (2023) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.28624 · Cited by 33 · see citing works
Differential effects of Fe2+ and Fe3+ on osteoblasts and the effects of 1,25(OH)2D3, deferiprone and extracellular calcium on osteoblast viability under iron-overloaded conditions
Lertsuwan, K., Nammultriputtar, K., Nanthawuttiphan, S., Tannop, N., Teerapornpuntakit, J., Thongbunchoo, J., & Charoenphandhu, N. (2020) · PLoS ONE · doi:10.1371/journal.pone.0234009 · Cited by 32 · see citing works
Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis
Benyamin, B., Esko, T., Ried, J. S., Radhakrishnan, A., Vermeulen, S. H., Traglia, M., Gögele, M., Anderson, D., Broer, L., Podmore, C., et al. (2014) · Nature Communications · doi:10.1038/ncomms5926 · Cited by 30 · see citing works
“6).”
Oligopeptides from Jinhua ham prevent alcohol-induced liver damage by regulating intestinal homeostasis and oxidative stress in mice
Nie, W., Du, Y., Xu, F., Zhou, K., Wang, Z., Al‐Dalali, S., Wang, Y., Li, X., Ma, Y., Xie, Y., et al. (2021) · Food & Function · doi:10.1039/d1fo01693h · Cited by 30 · see citing works
TCDD promotes liver fibrosis through disordering systemic and hepatic iron homeostasis
Li, C., Liu, Y., Dong, Z., Xu, M., Gao, M., Cong, M., & Liu, S. (2020) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2020.122588 · Cited by 28 · see citing works
Dietary Iron Overload Differentially Modulates Chemically-Induced Liver Injury in Rats
Mori, M., Izawa, T., Inai, Y., Fujiwara, S., Aikawa, R., Kuwamura, M., & Yamate, J. (2020) · Nutrients · doi:10.3390/nu12092784 · Cited by 28 · see citing works
Bioimaging of copper deposition in Wilson's diseases mouse liver by laser ablation inductively coupled plasma mass spectrometry imaging (LA-ICP-MSI)
M‐M, P., Merle, U., Weiskirchen, R., & Becker, J. S. (2013) · International Journal of Mass Spectrometry · doi:10.1016/j.ijms.2013.07.006 · Cited by 27 · see citing works
Iron overload reduces synthesis and elimination of bile acids in rat liver
Prašnická, A., Laštůvková, H., Faradonbeh, F. A., Cermanová, J., Hroch, M., Mokrý, J., Doleželová, E., Pávek, P., Žížalová, K., Vı́tek, L., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-46150-7 · Cited by 26 · see citing works
Catecholamine Stress Hormones Regulate Cellular Iron Homeostasis by a Posttranscriptional Mechanism Mediated by Iron Regulatory Protein
Tapryal, N., Vishnu Vivek, G., & Mukhopadhyay, C. K. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.592519 · Cited by 22 · see citing works
Hepatic Failure in COVID-19: Is Iron Overload the Dangerous Trigger?
Nonno, F. D., Nardacci, R., Colombo, D., Comandini, U. V., Cicalini, S., Antinori, A., Marchioni, L., D’Offizi, G., Piacentini, M., & Falasca, L. (2021) · Cells · doi:10.3390/cells10051103 · Cited by 22 · see citing works
Phlebotomy improves histology in chronic hepatitis C males with mild iron overload
Sartori, M. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i5.596 · Cited by 20 · see citing works
A case–control histological study on the effects of phlebotomy in patients with chronic hepatitis C
Sartori, M., Andorno, S., Rossini, A., Boldorini, R. L., Bozzola, C., Carmagnola, S., Piano, M. D., & Albano, E. (2011) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0b013e328349923c · Cited by 19 · see citing works
Prognostic Value of Serum Iron, Ferritin, and Transferrin in Chronic Alcoholic Liver Disease
Ribot-Hernández, I., Martín‐González, C., Vera-Delgado, V. E., Navarrete, L. G., de Armas-González, J. F., Viña-Rodríguez, J., Sánchez-Pérez, M. J., Rodrı́guez-Gaspar, M., & González‐Reimers, E. (2019) · Biological Trace Element Research · doi:10.1007/s12011-019-01887-0 · Cited by 20 · see citing works
Iron chelation by deferasirox confers protection against concanavalin A-induced liver fibrosis: A mechanistic approach
Adel, N., Mantawy, E. M., Elsherbiny, D. A., & El‐Demerdash, E. (2019) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2019.114748 · Cited by 18 · see citing works
Iron, Oxidative Stress and Health
Udipi, S., Ghugre, P., & Gokhale, C. (2012) · Oxidative Stress - Molecular Mechanisms and Biological Effects · doi:10.5772/34975 · Cited by 17 · see citing works
Iron overload triggering ECM-mediated Hippo/YAP pathway in follicle development: a hypothetical model endowed with therapeutic implications
Xia, L., Shen, Y., Liu, S., & Du, J. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1174817 · Cited by 16 · see citing works
Endometriosis Stem Cells as a Possible Main Target for Carcinogenesis of Endometriosis-Associated Ovarian Cancer (EAOC)
Wilczyński, J. R., Szubert, M., Paradowska, E., & Wilczyński, M. (2022) · Cancers · doi:10.3390/cancers15010111 · Cited by 15 · see citing works
Anti-Oxidant and Anti-Inflammatory Effects of Lipopolysaccharide from Rhodobacter sphaeroides against Ethanol-Induced Liver and Kidney Toxicity in Experimental Rats
Mehanna, E. T., Ali, A.-S. A., El-shaarawy, F. F., Mesbah, N. M., Abo–Elmatty, D. M., & Aborehab, N. M. (2021) · Molecules · doi:10.3390/molecules26247437 · Cited by 15 · see citing works
Combined histological and hematological assessment of iron-induced organ damage in a gerbil model of iron overload.
Wang, M., Liu, R., Wang, C., Kang, W., Yang, G., Zhong, W., & Lai, Y.-R. (2015) · PubMed Central · Cited by 14 · see citing works
Early Detection of Hepatocellular Carcinoma: How to Screen and Follow up Patients with Liver Cirrhosis According to the GERMAN S3 Guideline?
Plentz, R. R., & Malek, N. P. (2015) · Diagnostics · doi:10.3390/diagnostics5040497 · Cited by 13 · see citing works
Evaluation of serum iron overload, AST:ALT ratio and log10ferritin:AST ratio among schizophrenia patients in the Kumasi Metropolis, Ghana: a case–control study
Owiredu, W. K. B. A., Brenya, P. K., Osei, Y., Laing, E. F., Opoku-Okrah, C., Obirikorang, C., Anto, E. O., Acheampong, E., & Donkor, S. (2019) · BMC Research Notes · doi:10.1186/s13104-019-4847-2 · Cited by 13 · see citing works
Nonalcoholic Fatty Liver Disease and Gut-liver Axis: Role of Intestinal Microbiota and Therapeutic Mechanisms
Joon, A., Sharma, A., Jalandra, R., Bayal, N., Dhar, R., & Karmakar, S. (2024) · Journal of Translational Gastroenterology · doi:10.14218/jtg.2023.00018 · Cited by 11 · see citing works
Dietary Iron Overload Abrogates Chemically-Induced Liver Cirrhosis in Rats
Atarashi, M., Izawa, T., Mori, M., Inai, Y., Kuwamura, M., & Yamate, J. (2018) · Nutrients · doi:10.3390/nu10101400 · Cited by 11 · see citing works
Ameliorative Effect of Pomegranate Peel Extract (PPE) on Hepatotoxicity Prompted by Iron Oxide Nanoparticles (Fe2O3-NPs) in Mice
El‐Aziz, Y. M. A., Hendam, B. M., Al‐Salmi, F. A., Qahl, S. H., Althubaiti, E. H., Elsaid, F. G., Shati, A. A., Hosny, N. M., Fayad, E., & Almaaty, A. H. A. (2022) · Nanomaterials · doi:10.3390/nano12173074 · Cited by 10 · see citing works
TRANSIENT ELASTOGRAPHY (TE) IS A USEFUL TOOL FOR ASSESSING THE RESPONSE OF LIVER IRON CHELATION IN SICKLE CELL DISEASE PATIENTS
Delicou, S. (2018) · Mediterranean Journal of Hematology and Infectious Diseases · doi:10.4084/mjhid.2018.049 · Cited by 9 · see citing works
The iron chelating activity of Gundelia tournefortii in iron overloaded experimental rats
Mansi, K., Tabaza, Y., & Aburjai, T. A. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.113114 · Cited by 9 · see citing works
Fluorescence-Based Detection of Ferrous Iron in Senescent Cells
Parella, K. J., Manhardt, C. T., Capucilli, D., Moyer, B. S., Colegrove, H., Moody, K. J., Sleeper, M. B., Banas, A., Rebbaa, A., & Wolfe, A. J. (2021) · Rejuvenation Research · doi:10.1089/rej.2021.0075 · Cited by 8 · see citing works
Iron and Hepatitis C
Narang, T. K., Sendi, H., Scobey, M., & Bonkovsky, H. L. (2010) · Current Hepatology Reports · doi:10.1007/s11901-010-0049-z · Cited by 6 · see citing works
Subconjunctival Hemorrhages: Presenting Sign for Hereditary Hemochromatosis
Tong, J. W. H., & Sawamura, M. H. (2011) · Optometry and Vision Science · doi:10.1097/opx.0b013e3182223683 · Cited by 7 · see citing works
Liver injury in COVID-19: Holds ferritinophagy-mediated ferroptosis accountable
Jia, F., & Han, J.-H. (2022) · World Journal of Clinical Cases · doi:10.12998/wjcc.v10.i36.13148 · Cited by 7 · see citing works
Tanshinone IIA attenuates hepatic stellate cell activation, oxidative stress, and liver fibrosis by inhibiting YAP signaling
Wang, D., Tan, Q., Zheng, Q., Ma, Y., & Li, F. (2025) · European Journal of Histochemistry · doi:10.4081/ejh.2025.4218 · Cited by 6 · see citing works
The Protective Effects of Hydro-Alcoholic Extract of Coriandrum sativum in Rats with Experimental Iron-Overload Condition
Talaei, R., Kheirollah, A., Babaahmadi‐Rezaei, H., Mansouri, E., & Mohammadzadeh, G. (2017) · Jundishapur Journal of Natural Pharmaceutical Products · doi:10.5812/jjnpp.65028 · Cited by 6 · see citing works
Oxidative Stress in Iron Toxicity of the Liver
Mehta, K. J. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-803951-9.00004-5 · Cited by 6 · see citing works
The role of iron overload in the progression of nonalcoholic steatohepatitis (NASH)
Atarashi, M., Izawa, T., Kuwamura, M., & Yamate, J. (2019) · Folia Pharmacologica Japonica · doi:10.1254/fpj.154.61 · Cited by 6 · see citing works
Hepatic Pathobiology of Iron Overload
Ruddell, R. G., & Ramm, G. A. (2011) · Humana Press eBooks · doi:10.1007/978-1-60327-485-2_18 · Cited by 6 · see citing works
AASLD PRACTICE GUIDELINE Diagnosis and Management of Hemochromatosis: 2011 Practice Guideline by the American Association for the Study of Liver Diseases
Bacon, B. R., Adams, P. C., Kowdley, K. V., Powell, L. W., & Tavill, A. S. (2011) · Cited by 6 · see citing works
Clinical impact of HFE mutations in Japanese patients with chronic hepatitis C
Ishizu, Y., Katano, Y., Honda, T., Hayashi, K., Ishigami, M., Ito, A., Hirooka, Y., Nakano, I., & Goto, H. (2011) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2011.06976.x · Cited by 5 · see citing works
How much iron is too much?
Frazer, D. M., Anderson, G. J., Ramm, G. A., Subramaniam, V. N., & Powell, L. W. (2008) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2.3.287 · Cited by 5 · see citing works
Hyperferritinemia and liver iron content determined with MRI: Reintroduction of the liver iron index
Moris, W., Verbeek, J., Bakers, F. C. H., Rombout‐Sestrienkova, E., Innocenti, F., Masclee, A., Koek, G. H., & van Deursen, C. T. B. M. (2023) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2023.102224 · Cited by 4 · see citing works
Alcohol-Related Liver Disease
Maddur, H., & Flamm, S. L. (2025) · Clinics in Liver Disease · doi:10.1016/j.cld.2025.08.004 · Cited by 3 · see citing works
Metabolic disorders of the liver
Hafezi‐Bakhtiari, S., & Adeyi, O. A. (2014) · Diagnostic histopathology · doi:10.1016/j.mpdhp.2014.01.012 · Cited by 3 · see citing works
Difference in the Mechanism of Iron Overload–Enhanced Acute Hepatotoxicity Induced by Thioacetamide and Carbon Tetrachloride in Rats
Inai, Y., Izawa, T., Kamei, T., Fujiwara, S., Tanaka, M., Yamate, J., & Kuwamura, M. (2024) · Toxicologic Pathology · doi:10.1177/01926233241235623 · Cited by 2 · see citing works
Bilateral, geographic, peripapillary, chorioretinal atrophy in a patient with porphyria cutanea tarda and high iron stores
Denton, W. J., Jordan, C. W., & McGill, W. J. (2011) · Optometry · doi:10.1016/j.optm.2011.02.017 · Cited by 2 · see citing works
Potential Use of Patient-Specific Induced Pluripotent Stem Cell for Liver Fibrosis Thalassemia Treatment Management
Susanah, S., Widowati, W., Sari, N. M., Revika, R., Kusuma, H. S. W., Rizal, R., & Faried, A. (2022) · Open Access Macedonian Journal of Medical Sciences · doi:10.3889/oamjms.2022.8326 · Cited by 1 · see citing works
Regulation of Iron Metabolism in NAFLD/NASH
Hamada, Y., & Hirano, E. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.107221 · Cited by 1 · see citing works
Haptoglobin polymorphisms and their relationship to the activities of liver function enzymes in sickle cell anemia and hepatitis C patients
Jumaa, S. S., Maktoof, A. A., & Nuhair, R. S. (2024) · Pediatric Hematology/Oncology and Immunopathology · doi:10.24287/1726-1708-2024-23-4-72-77 · Cited by 1 · see citing works
Hyperferritinemia and the Risk of Liver Fibrosis and Liver-Related Events in Patients with Type 2 Diabetes Mellitus and Metabolic Dysfunction-Associated Steatotic Liver Disease
Cernea, S., Roiban, A. L., & Onișor, D. M. (2025) · Medicina · doi:10.3390/medicina61091518 · Cited by 1 · see citing works
Cytoprotective Effects of Artemisia princeps Extract through Inhibition of Mitochondrial Dysfunction
Choi, H. Y., Jegal, K. H., Kim, Y. W., Lee, J. W., Jo, S. A., Cho, I. J., & Kim, S. C. (2013) · Herbal Formula Science · doi:10.14374/hfs.2013.21.2.063 · Cited by 1 · see citing works
Synergistic Effect of LPS, IFN-γ and Iron on Apoptosis of Balb/c Mice Macrophages Following Nitric Oxide Production
Pirdel, L., & Hosseini, A. Z. (2008) · doi:10.22038/ijbms.2008.5230
Characterization of iron uptake into mitochondria of Saccharomyces cerevisiae
Wang, J. (2015)
Hepcidin knockout mice as a model of iron-overload associated liver disease
Lunová, M., Vaulont, S., Haybaeck, J., Lackner, K., Adler, G., & Strnad, P. (2011) · Zeitschrift für Gastroenterologie · doi:10.1055/s-0030-1269571
Hepatic Fibrosis is Common in β-Thalassaemiaand is Associated with Current and HistoricalIron Loading and Hepatitis C
Shelton, E., Chong, C. P., Shochet, L. R., heong, J., Ong, S. Y., Bowden, D. K., Alex, A., Hodge, E., Knight, V., Cheng, K. S., et al. (2016) · Journal of Hepatitis
Hepatoprotective Effect Of Ethilendiaminotetracetic Acid And Sodium Selenate In A Chronic Hepatic Failure Model In Mice
(2012) · The Internet Journal of Gastroenterology · doi:10.5580/2b86
Metabolic and Genetic Liver Diseases: Hemochromatosis
Stotts, M. J., & Bacon, B. R. (2016) · Springer eBooks · doi:10.1007/978-3-319-30103-7_20
Intensity of liver parenchym fibrosis in patients with alcoholic and non-alcoholic steatohepatitis depending on the presence of dysmetabolic iron overload syndrome
Хухліна, О. С., Антофійчук, Т. М., Антонів, А. А., & Антофійчук, М. П. (2021) · Modern Gastroenterology · doi:10.30978/mg-2021-3-26
Acoustic radiation force impulse elastography for liver iron overload in β‐thalassemia major: Is it going to cut it?
Alessandrino, F., & Cantisani, V. (2022) · Journal of Clinical Ultrasound · doi:10.1002/jcu.23104
Research Progress on the Role of Iron Overload in Chronic Viral Hepatitis B
丁, 银. (2022) · Advances in Clinical Medicine · doi:10.12677/acm.2022.123262
Hemochromatosis
Bacon, B. R., & Britton, R. S. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-6189-2.00074-3
Recent advances in genetic iron overload-related disorders
Moris, W. (2022) · doi:10.26481/dis.20220629wm
Inverse association between serum iron and liver stiffness
Chen, W., Cheng, Y., Wu, C., Sung, C., Hung, C.-C., & Kao, H.-L. (2023) · Journal of Medical Sciences · doi:10.4103/jmedsci.jmedsci_71_22
Small Molecules and Nanoparticles in Bone Healing: A Transformative Pathway in Tissue Engineering
Monisha, K., & Narayan, S. (2025) · Regenerative Engineering and Translational Medicine · doi:10.1007/s40883-025-00423-y
Role of Bee Bread in Modulating Liver Changes in Rats Fed a High-Fat Diet: Biochemical Mechanisms and Micronutrient Effects
Zakaria, Z., Noh, A. S. M., Othman, Z. A., Ghazali, W. S. W., & Mohamed, M. (2026) · Advances in biochemistry in health and disease · doi:10.1007/978-3-032-14441-6_7
Increased Brownian Motion of Water Molecules in Livers With Advanced Fibrosis: Preclinical and Clinical Observations With Magnetic Resonance Imaging (MRI)
Xu, F., Hu, G., Zheng, C., Huang, H., Luo, J.-Q., Zheng, G.-P., Duan, X., Loffroy, R., & Wáng, Y. X. J. (2026) · Molecular Imaging · doi:10.1177/15353508261465601
Iron accumulation in non-transfusion-dependent thalassemia: From molecular mechanisms to clinical practice
Garg, R., & Kishore, R. (2026) · Journal of Hematology and Allied Sciences · doi:10.25259/jhas_23_2026
Iron metabolism disorders in liver fibrosis and molecular therapy with standardized human placenta hydrolysate peptides
Громова, О. А., & Torshin, I. Y. (2026) · Meditsinskiy sovet = Medical Council · doi:10.21518/ms2026-421

Authors: Philippe, M. A.
Affiliations: QIMR Berghofer Medical Research Institute (AU)
Corresponding author: Philippe, Marie A
Venue: World Journal of Gastroenterology
Publisher: Baishideng Publishing Group Inc.
Published: 2007
Volume: 13
Issue: 35
Pages: 4746
ISSN: 1007-9327 (ISSN-L)
DOI: 10.3748/wjg.v13.i35.4746
PMC: PMC4611196
OpenAlex: W82514004
Cited by: 95
References: 100
Citations by year: 2026: 4 · 2025: 4 · 2024: 3 · 2023: 5 · 2022: 9 · 2021: 6 · 2020: 7 · 2019: 7 · 2018: 5 · 2017: 3 · 2016: 3 · 2015: 5 · 2014: 5 · 2013: 5 · 2012: 2
FWCI: 0.58
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc
Locations: World Journal of Gastroenterology (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
Keywords: iron, liver fibrosis, liver cirrhosis, oxidative stress, iron overload, iron deficiency, hepatic stellate cells, extracellular matrix deposition, matrix metalloproteinases, TIMP-1, wound healing, hepatocellular carcinoma, iron metabolism, iron storage, iron excretion, iron deficiency anemia, iron overload cardiomyopathy
MeSH terms: Humans, Iron, Liver Cirrhosis, Oxidative Stress, Disease Progression

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Role of iron in hepatic fibrosis: One piece in the puzzle

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks