The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Nonalcoholic steatohepatitis: what we know in the new millennium1
Abstract
Nonalcoholic steatohepatitis (NASH) is a liver disease characterized by diffuse fatty infiltration and inflammation. The exact prevalence of NASH is unclear, but it is becoming more evident that the disease is much more common than previously thought. Although generally a benign, indolent process, it can progress to advanced liver disease in approximately 15-20% of patients. Clinical characteristics associated with NASH include obesity, hyperlipidemia, diabetes mellitus, and hypertension, all of which have been associated with underlying insulin resistance. Typically, this disease becomes evident in the fourth or fifth decade of life with an equal sex predilection. NASH is thought to be caused, in part, by impaired insulin signaling, leading to elevated circulating insulin levels and subsequent altered lipid homeostasis. This process is likely multifactorial and includes both genetic and environmental factors. Treatment options to date are limited and are based on very small clinical trials. Current investigations are focusing on improving the underlying insulin resistance that has been associated with NASH as well as other therapies that decrease oxidative stress or improve hepatocyte survival.
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Cites
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Positive and Negative Regulation of Insulin Signaling by Reactive Oxygen and Nitrogen Species
Bashan, N., Kovsan, J., Kachko, I., Ovadia, H., & Rudich, A. (2009) · Physiological Reviews · doi:10.1152/physrev.00014.2008 · Cited by 542
Longitudinal Gastrectomy as a Treatment for the High-Risk Super-Obese Patient
Almogy, G., Crookes, P. F., & Anthone, G. J. (2004) · Obesity Surgery · doi:10.1381/096089204323013479 · Cited by 288
Nelson, A., Torres, D. M., Morgan, A. E., Fincke, C., & Harrison, S. A. (2009) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e31819c392e · Cited by 230
Self-citationSurgical Management of Obesity: A Review of the Evidence Relating to the Health Benefits and Risks
Lara, M. D., Kothari, S. N., & Sugerman, H. J. (2005) · Treatments in Endocrinology · doi:10.2165/00024677-200504010-00006 · Cited by 107
Tai, C.-M., Huang, C.-K., Hwang, J.-C., Chiang, H., Chang, C.-Y., Lee, C.-T., Yu, M.-L., & Lin, J.-T. (2012) · Obesity Surgery · doi:10.1007/s11695-011-0579-7 · Cited by 91
Metadata
- Authors
- Harrison, S. A., Kadakia, S., Lang, K. A., & Schenker, S.
- Venue
- The American Journal of Gastroenterology
- Published
- 2002-11
- Volume
- 97
- Issue
- 11
- Pages
- 2714-2724
- ISSN
- 0002-9270 (ISSN-L)
- 1572-0241
- OpenAlex
- W2041213769
- Cited by
- 173
- References
- 13
- FWCI
- 12.36
- Type
- journal article
- Language
- en
- Open access
- closed
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- Harrison, S. A., Kadakia, S., Lang, K. A., & Schenker, S. (2002). Nonalcoholic steatohepatitis: what we know in the new millennium1. The American Journal of Gastroenterology. https://doi.org/10.1111/j.1572-0241.2002.07069.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
