Steatohepatitis: A tale of two “hits”?
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Impairment in mitochondrial function and ATP generation is observed in NAFLD.
“Impairment in mitochondrial function and ATP generation is also observed.”
From Intervention by picroside II on FFAs induced lipid accumulation and lipotoxicity in HepG2 cells (2021) · cites this paper as [8]
Oxidative stress contributes to the production of reactive oxygen species, lipid peroxidation products and decreases the levels of antioxidants such as superoxide dismutase, glutathione, and catalase.
“Oxidative stress contributes to the production of reactive oxygen species, lipid peroxidation products and decreases the levels of antioxidants such as superoxide dismutase, glutathione, and catalase.”
From Intervention by picroside II on FFAs induced lipid accumulation and lipotoxicity in HepG2 cells (2021) · cites this paper as [8]
Fat accumulation in Mecp2 mutant mice is a sign of perturbed metabolism that can lead to fatty liver disease when hepatic lipid accumulation is followed by an increase in oxidative and metabolic stress.
“This fat accumulation is a sign of perturbed metabolism that can lead to fatty liver disease (FLD) when hepatic lipid accumulation is followed by an increase in oxidative and metabolic stress50.”
From A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome (2013) · cites this paper as [50]
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“LDL, mg/dL 120,5 (66,2-175,7) 117,9 (35,0-165,5) 105 (89-122) HDL, mg/dL 43 (32-65)* 42 (25-105)* 57 (42-75)”
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- Authors
- Day, C. P., & James, O. F. W.
- ORCID
- Day, Christopher P.
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 1998-04
- Volume
- 114
- Issue
- 4
- Pages
- 842-845
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2144178804
- Cited by
- 4,285
- References
- 1
- Citations by year
- 2026: 58 · 2025: 100 · 2024: 161 · 2023: 177 · 2022: 194 · 2021: 236 · 2020: 185 · 2019: 197 · 2018: 212 · 2017: 252 · 2016: 248 · 2015: 261 · 2014: 248 · 2013: 253 · 2012: 223
- FWCI
- 14.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- steatohepatitis, nonalcoholic steatohepatitis, non-alcoholic fatty liver disease, pathogenesis, two-hit hypothesis
- MeSH terms
- Fatty Liver, Humans, Lipid Peroxidation, Cytochrome P-450 CYP2E1, Chemical and Drug Induced Liver Injury
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