Cited by 4,285Liver Disease Diagnosis and TreatmentAlcohol Consumption and Health EffectsLiver physiology and pathology

Steatohepatitis: A tale of two “hits”?

Day, Christopher P., James, Oliver F.W.·1998·Gastroenterology

Integrity signals

Registry

Crossref · 10.1016/s0016-5085(98)70599-2

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1 of 1 references verified0 citation errors · 0 not checkable

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  • Impairment in mitochondrial function and ATP generation is observed in NAFLD.

    “Impairment in mitochondrial function and ATP generation is also observed.”
  • Oxidative stress contributes to the production of reactive oxygen species, lipid peroxidation products and decreases the levels of antioxidants such as superoxide dismutase, glutathione, and catalase.

    “Oxidative stress contributes to the production of reactive oxygen species, lipid peroxidation products and decreases the levels of antioxidants such as superoxide dismutase, glutathione, and catalase.”
  • Fat accumulation in Mecp2 mutant mice is a sign of perturbed metabolism that can lead to fatty liver disease when hepatic lipid accumulation is followed by an increase in oxidative and metabolic stress.

    “This fat accumulation is a sign of perturbed metabolism that can lead to fatty liver disease (FLD) when hepatic lipid accumulation is followed by an increase in oxidative and metabolic stress50.”

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Authors
Day, C. P., & James, O. F. W.
Venue
Gastroenterology
Publisher
Elsevier BV
Published
1998-04
Volume
114
Issue
4
Pages
842-845
ISSN
0016-5085 (ISSN-L)
OpenAlex
W2144178804
Cited by
4,285
References
1
Citations by year
2026: 58 · 2025: 100 · 2024: 161 · 2023: 177 · 2022: 194 · 2021: 236 · 2020: 185 · 2019: 197 · 2018: 212 · 2017: 252 · 2016: 248 · 2015: 261 · 2014: 248 · 2013: 253 · 2012: 223
FWCI
14.50
Type
journal article
Language
en
Open access
closed
Locations
  • Gastroenterology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Keywords
steatohepatitis, nonalcoholic steatohepatitis, non-alcoholic fatty liver disease, pathogenesis, two-hit hypothesis
MeSH terms
Fatty Liver, Humans, Lipid Peroxidation, Cytochrome P-450 CYP2E1, Chemical and Drug Induced Liver Injury

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