The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Eosinophils in the Esophagus—Peptic or Allergic Eosinophilic Esophagitis? Case Series of Three Patients with Esophageal Eosinophilia
Abstract
OBJECTIVES: Scattered eosinophils in the distal esophagus traditionally provide the hallmark for peptic esophagitis, but the upper limit of eosinophils and the longitudinal extent of peptic inflammation along the esophagus are unknown. Recently, adults and children with upper intestinal symptoms and >20 eosinophils/high-power field (eos/HPF) have been given the diagnosis of allergic esophagitis. Standardized diagnostic criteria for allergic esophagitis are lacking and the isolated finding of large numbers of eosinophils in the squamous epithelium has been used as the defining feature. We cared for three patients with symptoms and endoscopic features of esophagitis with >20 eos/HPF in their esophageal mucosa. Symptoms, endoscopic features, and histologic findings resolved after 2 months of proton pump inhibitor (PPI) treatment. The aim of this case series is to demonstrate that features thought to be consistent with a diagnosis of allergic esophagitis are also observed in peptic esophagitis. METHODS: A retrospective chart review of three patients with esophagitis (>20 eos/HPF) whose symptoms and eosinophilia resolved with PPI treatment was performed. Esophageal biopsies were reviewed in a blinded manner by one pathologist. RESULTS: Patients (aged 14, 25, and 5 yr) presented with dysphagia, food impaction, and vomiting. Endoscopic features included white exudates and linear furrows. None of the patients received antiallergic treatments or dietary eliminations prior to endoscopy. Following treatment with PPIs alone, all patients became asymptomatic and endoscopic findings reverted to normal. In all three patients, pre- and post-PPI treatment eosinophil numbers/HPF decreased to normal/near normal (37 to 1, 21 to 3, and 52 to 0 eosinophils/HPF in patients 1, 2, and 3, respectively). CONCLUSION: Large numbers of eosinophils can be seen in peptic esophagitis. This histologic finding must be interpreted in the context of the clinical setting in which it is obtained.
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Eosinophilic gastrointestinal disorders (EGID)
Rothenberg, M. E. (2004) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2003.10.047 · Cited by 923
Esophageal eosinophilia with dysphagia: A distinct clinicopathologic syndrome
Attwood, S. E. A., Smyrk, T. C., Demeester, T. R., & Jones, J. B. (1993) · Digestive Diseases and Sciences · doi:10.1007/bf01296781 · Cited by 884
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Primary Eosinophilic Esophagitis in Children: Successful Treatment with Oral Corticosteroids
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Intraepithelial Eosinophils: A New Diagnostic Criterion for Reflux Esophagitis
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The spectrum of pediatric eosinophilic esophagitis beyond infancy: a clinical series of 30 children
Orenstein, S. (2000) · The American Journal of Gastroenterology · doi:10.1016/s0002-9270(00)00865-0 · Cited by 420
Eosinophilic esophagitis in adults: An emerging problem with unique esophageal features
Potter, J. W., Saeian, K., Staff, D., Massey, B. T., Komorowski, R. A., Shaker, R., & Hogan, W. J. (2004) · Gastrointestinal Endoscopy · doi:10.1016/s0016-5107(03)02713-5 · Cited by 277
Allergic Esophagitis in Children: A Clinicopathological Entity
Walsh, S. V., Antonioli, D. A., Goldman, H., Fox, V. L., Bousvaros, A., Leichtner, A. M., & Furuta, G. T. (1999) · The American Journal of Surgical Pathology · doi:10.1097/00000478-199904000-00003 · Cited by 262
Self-citationUntersmayr, E. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(03)00025-3 · Cited by 246
Cited by
Eosinophilic esophagitis: Updated consensus recommendations for children and adults
Liacouras, C. A., Furuta, G. T., Hirano, I., Atkins, D., Attwood, S. E., Bonis, P. A., Burks, A. W., Chehade, M., Collins, M. H., Dellon, E. S., et al. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.02.040 · Cited by 2,073
Self-citationFuruta, G. T., Liacouras, C. A., Collins, M. H., Gupta, S. K., Justinich, C., Putnam, P. E., Bonis, P., Hassall, E., Straumann, A., & Rothenberg, M. E. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.08.017 · Cited by 1,673
Self-citationDellon, E. S., Liacouras, C. A., Molina-Infante, J., Furuta, G. T., Spergel, J. M., Zevit, N., Spechler, S. J., Attwood, S. E., Straumann, A., Aceves, S. S., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.07.009 · Cited by 1,162
Self-citationDellon, E. S., Gonsalves, N., Hirano, I., Furuta, G. T., Liacouras, C. A., & Katzka, D. A. (2013) · American Journal of Gastroenterology · doi:10.1038/ajg.2013.71 · Cited by 1,159
Self-citationSpechler, S. J., Genta, R. M., & Souza, R. F. (2007) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01179.x · Cited by 358
Metadata
- Authors
- Ngo, P., Furuta, G. T., Antonioli, D. A., & Fox, V. L.
- Venue
- The American Journal of Gastroenterology
- Published
- 2006-07
- Volume
- 101
- Issue
- 7
- Pages
- 1666-1670
- ISSN
- 0002-9270 (ISSN-L)
- 1572-0241
- OpenAlex
- W2031413046
- Cited by
- 306
- References
- 14
- FWCI
- 28.68
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ngo, P., Furuta, G. T., Antonioli, D. A., & Fox, V. L. (2006). Eosinophils in the Esophagus—Peptic or Allergic Eosinophilic Esophagitis? Case Series of Three Patients with Esophageal Eosinophilia. The American Journal of Gastroenterology. https://doi.org/10.1111/j.1572-0241.2006.00562.x
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