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Cited by 104Esophageal Cancer Research and TreatmentGastroesophageal reflux and treatmentsEsophageal and GI Pathology

Risk Factors for the Development of Esophageal Adenocarcinoma in Barrett's Esophagus

de Jonge, Pieter J F, Steyerberg, Ewout W, Kuipers, Ernst J, Honkoop, Pieter, Wolters, Leonieke M M, Kerkhof, Marjon, van Dekken, Horman, Siersema, Peter D·2006·The American Journal of Gastroenterology
DOI 10.1111/j.1572-0241.2006.00626.x
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Abstract

OBJECTIVE: To identify risk factors for esophageal adenocarcinoma (EAC) in patients with Barrett's esophagus (BE). METHODS: A hospital-based case-control study was performed in which 91 cases with EAC and 244 controls with histologically confirmed BE (>2 cm) with no dysplasia or low-grade dysplasia were included. Information on demographic, anthropometric, and lifestyle characteristics, physical activity levels, working posture, family history, gastroesophageal reflux disease (GERD) symptoms, and medication use was collected by questionnaire. RESULTS: Cases more often were current smokers (odds ratio 3.7, 95% confidence interval 1.4-9.9), more often had a body mass index >25 assessed at age 20 (2.6, 1.2-5.5), and more frequently had been working in a stooped posture at age 20 (2.0, 1.1-3.9), compared to controls. In addition, cases less often experienced symptoms of heartburn (0.3, 0.2-0.5) and less frequently used proton pump inhibitors (0.1, 0.05-0.2), compared to controls, whereas use of nonsteroidal anti-inflammatory drugs/aspirin was more common among cases (1.8, 1.1-3.2). Cases more often were men, compared to controls (91%vs 67%, p < 0.001). CONCLUSION: In patients with BE, the risk of EAC is related to risk factors for GERD, which is, however, asymptomatic. As these risk factors are common in Western countries, they are probably not helpful in individualization of surveillance intervals.

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Authors
de Jonge, P. J. F., Steyerberg, E. W., Kuipers, E. J., Honkoop, P., Wolters, L. M. M., Kerkhof, M., van Dekken, H., & Siersema, P. D.
Affiliations
Erasmus MC (NL)
Corresponding author
Siersema, Peter D
ORCID
Venue
The American Journal of Gastroenterology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2006-07
Volume
101
Issue
7
Pages
1421-1429
ISSN
  • 0002-9270 (ISSN-L)
  • 1572-0241
DOI
10.1111/j.1572-0241.2006.00626.x
OpenAlex
W2066962389
Cited by
104
References
48
Citations by year
2025: 2 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 8 · 2020: 3 · 2019: 7 · 2018: 2 · 2017: 9 · 2016: 3 · 2015: 9 · 2014: 7 · 2013: 8 · 2012: 3
FWCI
8.13
Type
journal article
Language
en
Open access
closed
Locations
  • The American Journal of Gastroenterology (publishedVersion)
  • PubMed (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Esophageal Cancer Research and Treatment
  • Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
  • Health Sciences › Medicine › Surgery › Esophageal and GI Pathology
Keywords
esophageal adenocarcinoma, Barrett's esophagus, risk factors, gastroesophageal reflux disease, smoking, body mass index, proton pump inhibitors, nonsteroidal anti-inflammatory drugs, aspirin, surveillance interval
MeSH terms
Adenocarcinoma, Anti-Inflammatory Agents, Non-Steroidal, Anti-Ulcer Agents, Barrett Esophagus, Educational Status, Esophageal Neoplasms, Female, Humans, Male, Middle Aged, Netherlands, Posture, Surveys and Questionnaires, Risk Factors, Smoking, Body Mass Index, Chi-Square Distribution, Logistic Models, Case-Control Studies

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