The DOI matches its Crossref record; 100 of the 100 references it cites were found in a registry or an index.
Fibrogenesis in Crohn's Disease
Abstract
INTRODUCTION: Over one-third of patients with Crohn's disease (CD) will develop an intestinal stricture and the great majority of these will require at least one surgical procedure. While the pathogenesis of inflammation in CD has been extensively investigated, knowledge of stricture pathogenesis remains limited. The aim of this review is to discuss the current understanding of fibrogenesis in CD and to outline potential directions in research and therapeutics. METHODS: The electronic literature (January 1966 to May 2006) on CD-associated fibrosis was reviewed. Further references were obtained by cross-referencing from key articles. RESULTS: CD-associated fibrosis results from chronic transmural inflammation and a complex interplay among intestinal mesenchymal cells, cytokines, and local inflammatory cells. The fibroblast is the key cell type mediating stricture formation. The cytoarchitecure of the bowel wall is altered with disruption of the muscularis mucosa, thickening of the muscularis propria, and deposition of collagen throughout. The cytokine TGF-beta appears critical in this process, acting to increase growth factor and extracellular matrix (ECM) production and dysregulate ECM turnover. Potential therapeutic interventions are likely to concentrate on modulating down-stream targets of TGF-beta. CONCLUSIONS: Greater understanding of the biology of fibrostenosis is likely to yield significant advances in our ability to care for patients with stricturing CD. Potential dividends of this approach include identification of novel therapeutic targets and biomarkers useful for prognostication and therapeutic monitoring.
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Cites
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Prud'homme, G. J. (2007) · Laboratory Investigation · doi:10.1038/labinvest.3700669 · Cited by 419
Rieder, F., Kessler, S., Sans, M., & Fiocchi, C. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00059.2012 · Cited by 135
Taming the Elephant: Salmonella Biology, Pathogenesis, and Prevention
Andrews-Polymenis, H. L., Bäumler, A. J., McCormick, B. A., & Fang, F. C. (2010) · Infection and Immunity · doi:10.1128/iai.00096-10 · Cited by 114
Prophylactic systemic P2X7 receptor blockade prevents experimental colitis
Marques, C. C., Castelo-Branco, M. T., Pacheco, R. G., Buongusto, F., do Rosário, A., Schanaider, A., Coutinho-Silva, R., & de Souza, H. S. P. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.10.012 · Cited by 78
Metadata
- Authors
- Burke, J. P., Mulsow, J. J., O'Keane, C., Docherty, N. G., Watson, R. W. G., & O'Connell, P. R.
- Venue
- The American Journal of Gastroenterology
- Published
- 2007-02
- Volume
- 102
- Issue
- 2
- Pages
- 439-448
- ISSN
- 0002-9270 (ISSN-L)
- 1572-0241
- OpenAlex
- W1997413662
- Cited by
- 279
- References
- 100
- FWCI
- 5.30
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
