Animal models of intestinal fibrosis: new tools for the understanding of pathogenesis and therapy of human disease
Open accessAbstract
Fibrosis is a serious condition complicating chronic inflammatory processes affecting the intestinal tract. Advances in this field that rely on human studies have been slow and seriously restricted by practical and logistic reasons. As a consequence, well-characterized animal models of intestinal fibrosis have emerged as logical and essential systems to better define and understand the pathophysiology of fibrosis. In point of fact, animal models allow the execution of mechanistic studies as well as the implementation of clinical trials with novel, pathophysiology-based therapeutic approaches. This review provides an overview of the currently available animal models of intestinal fibrosis, taking into consideration the methods of induction, key characteristics of each model, and underlying mechanisms. Currently available models will be classified into seven categories: spontaneous, gene-targeted, chemical-, immune-, bacteria-, and radiation-induced as well as postoperative fibrosis. Each model will be discussed in regard to its potential to create research opportunities to gain insights into the mechanisms of intestinal fibrosis and stricture formation and assist in the development of effective and specific antifibrotic therapies.
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Increased levels of LPS in the portal vein or translocation of whole bacteria or their products to the liver activates inflammation that leads to fibrosis.
“Increased levels of the microbe-derived ligand lipopolysaccaride (LPS) in the portal vein or translocation of whole bacteria or their products to the liver activates inflammation that leads to fibrosis161,162”
From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [162]
Dysbiosis in the gut influences liver fibrosis.
“Dysbiosis in the gut has been shown to influence liver fibrosis as well.”
From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [162]
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Animal Models of Epigenetic Inheritance
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Role of heat shock protein 47 in intestinal fibrosis of experimental colitis
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Regulation of Postsurgical Fibrosis by the Programmed Death-1 Inhibitory Pathway
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Smad, but not MAPK, pathway mediates the expression of type I collagen in radiation induced fibrosis
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Myofibroblasts and colonic anastomosis healing in Wistar rats
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Treatment of Postoperative Crohn’s Disease
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Smad3 knock-out mice as a useful model to study intestinal fibrogenesis
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The effect of oral honey and pollen on postoperative intraabdominal adhesions
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Why study animal models of IBD?
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INFLUENCE OF FRACTION SIZE ON THE DEVELOPMENT OF LATE RADIATION ENTEROPATHY
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Why study animal models of IBD?
Strober, W. (2008) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200810001-00063 · Cited by 3 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
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Yang, C., & Merlin, D. (2023) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izad312 · Cited by 253 · see citing works
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Macias-Ceja, D. C., Ortiz‐Masiá, D., Salvador, P., Gisbert-Ferrándiz, L., Hernández, C., Hausmann, M., Rogler, G., Esplugues, J. V., Hinojosa, J., Alós, R., et al. (2018) · Mucosal Immunology · doi:10.1038/s41385-018-0087-3 · Cited by 237 · see citing works
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Lu, Q., Yang, M.-F., Liang, Y.-J., Xu, J., Xu, H.-M., Nie, Y.-Q., Wang, L.-S., Yao, J., & Li, D.-F. (2022) · Journal of Inflammation Research · doi:10.2147/jir.s353038 · Cited by 220 · see citing works
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Rieder, F., Mukherjee, P. K., Massey, W. J., Wang, Y., & Fiocchi, C. (2024) · Gut · doi:10.1136/gutjnl-2023-329963 · Cited by 205 · see citing works
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Lawrance, I. C., Rogler, G., Bamias, G., Breynaert, C. M., Florholmen, J. R., Pellino, G., Reif, S. S., Speca, S., & Latella, G. (2014) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2014.09.008 · Cited by 176 · see citing works
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Latella, G., Rogler, G., Bamias, G., Breynaert, C. M., Florholmen, J., Pellino, G., Reif, S. S., Speca, S., & Lawrance, I. C. (2014) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2014.03.008 · Cited by 169 · see citing works
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Siegmund, B., Feakins, R. M., Bamias, G., Ludvig, J. C., Teixeira, F. V., Rogler, G., & Scharl, M. M. (2015) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjv228 · Cited by 119 · see citing works
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- Authors
- Rieder, F., Kessler, S., Sans, M., & Fiocchi, C.
- Affiliations
- Cleveland Clinic (US)
- Hospital Quirón Teknon (ES)
- Corresponding author
- Fiocchi, Claudio
- Venue
- American Journal of Physiology-Gastrointestinal and Liver Physiology
- Publisher
- American Physiological Society
- Published
- 2012-10-01
- Volume
- 303
- Issue
- 7
- Pages
- G786-G801
- ISSN
- 0193-1857 (ISSN-L)
- 1522-1547
- PMC
- PMC4073977
- OpenAlex
- W2160911117
- Cited by
- 135
- References
- 165
- Citations by year
- 2026: 2 · 2025: 11 · 2024: 11 · 2023: 8 · 2022: 5 · 2021: 15 · 2020: 19 · 2019: 10 · 2018: 13 · 2017: 7 · 2016: 11 · 2015: 8 · 2014: 8 · 2013: 6
- FWCI
- 0.86
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Physiology-Gastrointestinal and Liver Physiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (T32DK083251)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Surgery › Intestinal and Peritoneal Adhesions
- Health Sciences › Medicine › Pathology and Forensic Medicine › Systemic Sclerosis and Related Diseases
- Keywords
- intestinal fibrosis, animal models, fibrosis pathogenesis, antifibrotic therapy, intestinal stenosis, radiation-induced fibrosis, postoperative fibrosis, chronic intestinal inflammation
- MeSH terms
- Animals, Constriction, Pathologic, Disease Models, Animal, Drug Therapy, Fibrosis, Humans, Inflammation, Intestines, Postoperative Complications, Digestive System Surgical Procedures, Inflammatory Bowel Diseases, Gene Knockout Techniques, Translational Research, Biomedical
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