Cited by 135Inflammatory Bowel DiseaseIntestinal and Peritoneal AdhesionsSystemic Sclerosis and Related Diseases

Animal models of intestinal fibrosis: new tools for the understanding of pathogenesis and therapy of human disease

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Rieder, Florian, Kessler, Sean, Sans, Miquel, Fiocchi, Claudio·2012·American Journal of Physiology-Gastrointestinal and Liver Physiology

Abstract

Fibrosis is a serious condition complicating chronic inflammatory processes affecting the intestinal tract. Advances in this field that rely on human studies have been slow and seriously restricted by practical and logistic reasons. As a consequence, well-characterized animal models of intestinal fibrosis have emerged as logical and essential systems to better define and understand the pathophysiology of fibrosis. In point of fact, animal models allow the execution of mechanistic studies as well as the implementation of clinical trials with novel, pathophysiology-based therapeutic approaches. This review provides an overview of the currently available animal models of intestinal fibrosis, taking into consideration the methods of induction, key characteristics of each model, and underlying mechanisms. Currently available models will be classified into seven categories: spontaneous, gene-targeted, chemical-, immune-, bacteria-, and radiation-induced as well as postoperative fibrosis. Each model will be discussed in regard to its potential to create research opportunities to gain insights into the mechanisms of intestinal fibrosis and stricture formation and assist in the development of effective and specific antifibrotic therapies.

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Crossref · 10.1152/ajpgi.00059.2012

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  • Increased levels of LPS in the portal vein or translocation of whole bacteria or their products to the liver activates inflammation that leads to fibrosis.

    “Increased levels of the microbe-derived ligand lipopolysaccaride (LPS) in the portal vein or translocation of whole bacteria or their products to the liver activates inflammation that leads to fibrosis161,162”

    From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [162]

  • Dysbiosis in the gut influences liver fibrosis.

    “Dysbiosis in the gut has been shown to influence liver fibrosis as well.”

    From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [162]

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Research works printed but not linked: 2

  1. [73]Leeb SN, Vogl D, Gunckel M, Kiessling S, Falk W, Goke M, Scholmerich J, Gelbmann CM, Rogler G. Reduced migration of fibroblasts in inflammatory bowel disease: role of inflammatory mediators and focal adhesion kinase. Gastroenterology 125: 1341–1354, 2003 [DOI] [PubMed] [Google Scholar]
  2. [102]Penner RM, Madsen KL, Fedorak RN. Postoperative Crohn's disease. Inflamm Bowel Dis 11: 765–777, 2005 [DOI] [PubMed] [Google Scholar]

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Authors
Rieder, F., Kessler, S., Sans, M., & Fiocchi, C.
Affiliations
  • Cleveland Clinic (US)
  • Hospital Quirón Teknon (ES)
Corresponding author
Fiocchi, Claudio
Venue
American Journal of Physiology-Gastrointestinal and Liver Physiology
Published
2012-10-01
Volume
303
Issue
7
Pages
G786-G801
ISSN
  • 0193-1857 (ISSN-L)
  • 1522-1547
OpenAlex
W2160911117
Cited by
135
References
165
Citations by year
2026: 2 · 2025: 11 · 2024: 11 · 2023: 8 · 2022: 5 · 2021: 15 · 2020: 19 · 2019: 10 · 2018: 13 · 2017: 7 · 2016: 11 · 2015: 8 · 2014: 8 · 2013: 6
FWCI
0.86
Type
journal article
Language
en
Open access
Locations
  • American Journal of Physiology-Gastrointestinal and Liver Physiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (T32DK083251)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
  • Health Sciences › Medicine › Surgery › Intestinal and Peritoneal Adhesions
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Systemic Sclerosis and Related Diseases
Keywords
intestinal fibrosis, animal models, fibrosis pathogenesis, antifibrotic therapy, intestinal stenosis, radiation-induced fibrosis, postoperative fibrosis, chronic intestinal inflammation
MeSH terms
Animals, Constriction, Pathologic, Disease Models, Animal, Drug Therapy, Fibrosis, Humans, Inflammation, Intestines, Postoperative Complications, Digestive System Surgical Procedures, Inflammatory Bowel Diseases, Gene Knockout Techniques, Translational Research, Biomedical

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