The DOI matches its Crossref record.
Effect of Antisecretory Drugs and Nitrates on the Risk of Ulcer Bleeding Associated With Nonsteroidal Anti-Inflammatory Drugs, Antiplatelet Agents, and Anticoagulants
Abstract
OBJECTIVES: After the withdrawal of some cyclooxygenase-2 (COX-2) selective inhibitors, traditional nonsteroidal anti-inflammatory drug (NSAID) use has increased, but without additional prevention strategies against upper gastrointestinal (GI) complications in many cases. Here, we report the effect of antisecretory drugs and nitrates on the risk of upper GI peptic ulcer bleeding (UGIB) associated with nonselective NSAIDs, aspirin, antiplatelet agents, and anticoagulants. METHODS: This case-control study matched 2,777 consecutive patients with UGIB (confirmed by endoscopy) with 5,532 controls (2:1). Adjusted relative risks (RR) of UGIB are reported. RESULTS: Proton pump inhibitors (PPIs) (RR 0.33, 95% confidence interval [CI] 0.27-0.39), H2-receptor antagonists (H2-RAs) (RR 0.65, 95% CI 0.50-0.85), and nitrates (RR 0.52, 95% CI 0.38-0.70) reduced UGIB risk. PPI use was associated with greater reductions among both traditional NSAID (RR 0.13, 95% CI 0.09-0.19 vs RR 0.30, 95% CI 0.17-0.53 with H2-RAs; RR 0.48, 95% CI 0.19-1.24 with nitrates) and low-dose aspirin users (RR 0.32, 95% CI 0.22-0.51 vs RR 0.40, 95% CI 0.19-0.73 with H2-RA; RR 0.69, 95% CI 0.36-1.04 with nitrates), and among patients taking clopidogrel (RR 0.19, 95% CI 0.07-0.49). For patients taking anticoagulants, use of nitrates, H2-RA, or PPIs was not associated with a significant effect on UGIB risk. CONCLUSION: Antisecretory agent or nitrate treatment is associated with reduced UGIB RR in patients taking NSAID or aspirin. Only PPI therapy was associated with a marked, consistent risk reduction among patients receiving all types of agents (including nonaspirin antiplatelet agents). Protection was not apparent in patients taking anticoagulants.
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Citations
Cited by
Lau, J. Y., Sung, J., Hill, C., Henderson, C., Howden, C. W., & Metz, D. C. (2011) · Digestion · doi:10.1159/000323958 · Cited by 580
Writing Committee Members, Abraham, N. S., Hlatky, M. A., Antman, E. M., Bhatt, D. L., Bjorkman, D. J., Clark, C. B., Furberg, C. D., Johnson, D. A., Kahi, C. J., et al. (2010) · Circulation · doi:10.1161/cir.0b013e318202f701 · Cited by 451
Hauta-Aho, M., Tirkkonen, T., Vahlberg, T., & Laine, K. (2009) · Annals of Medicine · doi:10.1080/07853890903186168 · Cited by 67
Metadata
- Authors
- Lanas, A., García-Rodríguez, L. A., Arroyo, M. T., Bujanda, L., Gomollón, F., Forné, M., Aleman, S., Nicolas, D., Feu, F., González-Pérez, A., Borda, A., Castro, M., Poveda, M. J., & Arenas, J.
- Venue
- The American Journal of Gastroenterology
- Published
- 2007-03
- Volume
- 102
- Issue
- 3
- Pages
- 507-515
- ISSN
- 0002-9270 (ISSN-L)
- 1572-0241
- OpenAlex
- W2096219546
- Cited by
- 298
- References
- 0
- FWCI
- 28.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Effect of Antisecretory Drugs and Nitrates on the Risk of Ulcer Bleeding Associated With Nonsteroidal Anti-Inflammatory Drugs, Antiplatelet Agents, and Anticoagulants. https://app.cochat.ai/papers/10.1111/j.1572-0241.2006.01062.x
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- Lanas, A., García-Rodríguez, L. A., Arroyo, M. T., Bujanda, L., Gomollón, F., Forné, M., Aleman, S., Nicolas, D., Feu, F., González-Pérez, A., Borda, A., Castro, M., Poveda, M. J., & Arenas, J. (2007). Effect of Antisecretory Drugs and Nitrates on the Risk of Ulcer Bleeding Associated With Nonsteroidal Anti-Inflammatory Drugs, Antiplatelet Agents, and Anticoagulants. The American Journal of Gastroenterology. https://doi.org/10.1111/j.1572-0241.2006.01062.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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