The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Systematic Review of the Epidemiology of Complicated Peptic Ulcer Disease: Incidence, Recurrence, Risk Factors and Mortality
Abstract
Background/Aims: The incidence of uncomplicated peptic ulcer has decreased in recent years. It is unclear what the impact of this has been on the epidemiology of peptic ulcer complications. This systematic review aimed to determine the incidence, recurrence and mortality of complicated peptic ulcer and the risk factors associated with these events. Methods: Systematic PubMed searches. Results: Overall, 93 studies were identified. Annual incidence estimates of peptic ulcer hemorrhage and perforation were 19.4–57.0 and 3.8–14 per 100,000 individuals, respectively. The average 7-day recurrence of hemorrhage was 13.9% (95% CI: 8.4–19.4), and the average long-term recurrence of perforation was 12.2% (95% CI: 2.5–21.9). Risk factors for peptic ulcer complications and their recurrence included nonsteroidal anti-inflammatory drug and/or acetylsalicylic acid use, Helicobacter pylori infection and ulcer size ≧1 cm. Proton pump inhibitor use reduced the risk of peptic ulcer hemorrhage. Average 30-day mortality was 8.6% (95% CI: 5.8–11.4) after hemorrhage and 23.5% (95% CI: 15.5–31.0) after perforation. Older age, comorbidity, shock and delayed treatment were associated with increased mortality. Conclusions: Complicated peptic ulcer remains a substantial healthcare problem which places patients at a high risk of recurrent complications and death.
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Cites
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Helicobacter pylori infection and chronic gastric acid hyposecretion
El-Omar, E., Oien, K., El-Nujumi, A., Gillen, D., Wirz, A., Dahill, S., Williams, C., Ardill, J., & McColl, K. (1997) · Gastroenterology · doi:10.1016/s0016-5085(97)70075-1 · Cited by 647
Clopidogrel versus Aspirin and Esomeprazole to Prevent Recurrent Ulcer Bleeding
Chan, F. K. L., Ching, J. Y. L., Hung, L. C. T., Wong, V. W. S., Leung, V. K. S., Kung, N. N. S., Hui, A. J., Wu, J. C. Y., Leung, W. K., Lee, V. W. Y., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa042087 · Cited by 629
Self-citationLanas, A., García-Rodríguez, L. A., Arroyo, M. T., Gomollón, F., Feu, F., González-Pérez, A., Zapata, E., Bástida, G., Rodrigo, L., Santolaria, S., et al. (2006) · Gut · doi:10.1136/gut.2005.080754 · Cited by 524
van Leerdam, M. E., Vreeburg, E. M., Rauws, E. A. J., Geraedts, A. A. M., Tijssen, J. G. P., Reitsma, J. B., & Tytgat, G. N. J. (2003) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2003.07517.x · Cited by 508
Epidemiology of NSAID induced gastrointestinal complications.
Singh, G., & Triadafilopoulos, G. (1999) · PubMed · Cited by 492
Lanas, A., García-Rodríguez, L. A., Arroyo, M. T., Bujanda, L., Gomollón, F., Forné, M., Aleman, S., Nicolas, D., Feu, F., González-Pérez, A., et al. (2007) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.01062.x · Cited by 298
Higham, J., Kang, J.-Y., & Majeed, A. (2002) · Gut · doi:10.1136/gut.50.4.460 · Cited by 238
Lassen, A., Hallas, J., & de Muckadell, O. B. S. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00518.x · Cited by 219
Cited by
WSES/GAIS/SIS-E/WSIS/AAST global clinical pathways for patients with intra-abdominal infections
Sartelli, M., Coccolini, F., Kluger, Y., Agastra, E., Abu-Zidan, F. M., Abbas, A. E. S., Ansaloni, L., Adesunkanmi, A. K., Atanasov, B., Augustin, G., et al. (2021) · World Journal of Emergency Surgery · doi:10.1186/s13017-021-00387-8 · Cited by 207
Metadata
- Authors
- Lau, J. Y., Sung, J., Hill, C., Henderson, C., Howden, C. W., & Metz, D. C.
- Venue
- Digestion
- Publisher
- S. Karger AG
- Published
- 2011
- Volume
- 84
- Issue
- 2
- Pages
- 102-113
- ISSN
- 0012-2823 (ISSN-L)
- 1421-9867
- OpenAlex
- W2026639275
- Cited by
- 580
- References
- 38
- FWCI
- 3.37
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Lau, J. Y., Sung, J., Hill, C., Henderson, C., Howden, C. W., & Metz, D. C. (2011). Systematic Review of the Epidemiology of Complicated Peptic Ulcer Disease: Incidence, Recurrence, Risk Factors and Mortality. Digestion. https://doi.org/10.1159/000323958
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
