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Cited by 198

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Genetic data indicate that proteins containing the GGDEF domain possess diguanylate cyclase activity

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Ausmees, N·2001·FEMS Microbiology Letters

Abstract

A conserved domain, called GGDEF (referring to a conserved central sequence pattern), is detected in many procaryotic proteins, often in various combinations with putative sensory-regulatory components. Most sequenced bacterial genomes contain several different GGDEF proteins. The function of this domain has so far not been experimentally shown. Through genetic complementation using genes from three different bacteria encoding proteins with GGDEF domains as the only element in common, we present genetic data indicating (a) that the GGDEF domain is responsible for the diguanylate cyclase activity of these proteins, and (b) that the activity of cellulose synthase in Rhizobium leguminosarum bv. trifolii and Agrobacterium tumefaciens is regulated by cyclic di-GMP as in Acetobacter xylinum.

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  • Cellulose biosynthesis and function in bacteria

    Ross, P., Mayer, R., & Benziman, M. (1991) · Microbiological Reviews · doi:10.1128/mmbr.55.1.35-58.1991 · Cited by 1,231 · cited 1×

    “Bacteria, however, seem to produce cellulose for various purposes and the biological advantages of this ability are not always obvious [6].”
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Metadata

Authors
Ausmees, N.
Venue
FEMS Microbiology Letters
Published
2001-10-16
Volume
204
Issue
1
Pages
163-167
ISSN
0378-1097 (ISSN-L)
OpenAlex
W1977906605
Cited by
198
References
1
FWCI
6.21
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Genetic data indicate that proteins containing the GGDEF domain possess diguanylate cyclase activity. https://app.cochat.ai/papers/10.1016/s0378-1097(01)00394-9
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Ausmees, N. (2001). Genetic data indicate that proteins containing the GGDEF domain possess diguanylate cyclase activity. FEMS Microbiology Letters. https://doi.org/10.1016/s0378-1097(01)00394-9

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