The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Strong antimicrobial activity of Lactobacillus rhamnosus GG against Salmonella typhimurium is due to accumulation of lactic acid
Abstract
Spent culture supernatant (SCS) of the probiotic Lactobacillus rhamnosus GG had been reported to exert antibacterial activity against Salmonella typhimurium. However, the chemical identity of the antimicrobial compound(s) responsible remained unknown. A survey of the antimicrobial compounds produced by L. rhamnosus GG was performed. Lactobacillus rhamnosus GG produced a low-molecular weight, heat-stable, non-proteinaceous bactericidal substance, active at acidic pH against a wide range of bacterial species. SCS of L. rhamnosus GG grown in MRS medium contained five compounds that could meet the above description, if present at the appropriate concentration. Based on different experimental approaches, it could be concluded that under the growth conditions tested, the strong antimicrobial activity of L. rhamnosus GG against Salmonella was mediated by lactic acid.
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Cited by
Genes and Molecules of Lactobacilli Supporting Probiotic Action
Lebeer, S., Vanderleyden, J., & De Keersmaecker, S. C. J. (2008) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00017-08 · Cited by 1,013
Self-citationVanderpool, C., Yan, F., & Polk, B. D. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20525 · Cited by 340
Probiotics and Prebiotics: Effects on Diarrhea1
de Vrese, M., & Marteau, P. R. (2007) · The Journal of Nutrition · doi:10.1093/jn/137.3.803s · Cited by 312
Arena, M. P., Silvain, A., Normanno, G., Grieco, F., Drider, D., Spano, G., & Fiocco, D. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00464 · Cited by 299
Tejero-Sariñena, S., Barlow, J., Costabile, A., Gibson, G. R., & Rowland, I. (2012) · Anaerobe · doi:10.1016/j.anaerobe.2012.08.004 · Cited by 296
Metadata
- Authors
- De Keersmaecker, S. C. J., Verhoeven, T. L. A., Desair, J., Marchal, K., Vanderleyden, J., & Nagy, I.
- Venue
- FEMS Microbiology Letters
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-06
- Volume
- 259
- Issue
- 1
- Pages
- 89-96
- ISSN
- 0378-1097 (ISSN-L)
- 1574-6968
- OpenAlex
- W2015701509
- Cited by
- 317
- References
- 31
- FWCI
- 10.81
- Type
- journal article
- Language
- en
- Open access
- closed
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- De Keersmaecker, S. C. J., Verhoeven, T. L. A., Desair, J., Marchal, K., Vanderleyden, J., & Nagy, I. (2006). Strong antimicrobial activity of Lactobacillus rhamnosus GG against Salmonella typhimurium is due to accumulation of lactic acid. FEMS Microbiology Letters. https://doi.org/10.1111/j.1574-6968.2006.00250.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
