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Cited by 447

The DOI matches its Crossref record; 106 of the 106 references it cites were found in a registry or an index.

Penicillin Binding Proteins: key players in bacterial cell cycle and drug resistance processes

Macheboeuf, Pauline, Contreras-Martel, Carlos, Job, Viviana, Dideberg, Otto, Dessen, Andréa·2006·FEMS Microbiology Reviews
DOI 10.1111/j.1574-6976.2006.00024.x
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Abstract

Bacterial cell division and daughter cell formation are complex mechanisms whose details are orchestrated by at least a dozen different proteins. Penicillin-binding proteins (PBPs), membrane-associated macromolecules which play key roles in the cell wall synthesis process, have been exploited for over 70 years as the targets of the highly successful beta-lactam antibiotics. The increasing incidence of beta-lactam resistant microorganisms, coupled to progress made in genomics, genetics and immunofluorescence microscopy techniques, have encouraged the intensive study of PBPs from a variety of bacterial species. In addition, the recent publication of high-resolution structures of PBPs from pathogenic organisms have shed light on the complex intertwining of drug resistance and cell division processes. In this review, we discuss structural, functional and biological features of such enzymes which, albeit having initially been identified several decades ago, are now being aggressively pursued as highly attractive targets for the development of novel antibiotherapies.

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Metadata

Authors
Macheboeuf, P., Contreras-Martel, C., Job, V., Dideberg, O., & Dessen, A.
Venue
FEMS Microbiology Reviews
Publisher
Oxford University Press (OUP)
Published
2006-09
Volume
30
Issue
5
Pages
673-691
ISSN
  • 0168-6445 (ISSN-L)
  • 1574-6976
DOI
10.1111/j.1574-6976.2006.00024.x
OpenAlex
W2035800315
Cited by
447
References
106
FWCI
11.31
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Penicillin Binding Proteins: key players in bacterial cell cycle and drug resistance processes. https://app.cochat.ai/papers/10.1111/j.1574-6976.2006.00024.x
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Macheboeuf, P., Contreras-Martel, C., Job, V., Dideberg, O., & Dessen, A. (2006). Penicillin Binding Proteins: key players in bacterial cell cycle and drug resistance processes. FEMS Microbiology Reviews. https://doi.org/10.1111/j.1574-6976.2006.00024.x

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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.