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Cited by 1,317

The DOI matches its Crossref record; 123 of the 123 references it cites were found in a registry or an index.

The penicillin-binding proteins: structure and role in peptidoglycan biosynthesis

Open access
Sauvage, Eric, Kerff, Frédéric, Terrak, Mohammed, Ayala, Juan A., Charlier, Paulette·2008·FEMS Microbiology Reviews

Abstract

Penicillin-binding proteins (PBPs) have been scrutinized for over 40 years. Recent structural information on PBPs together with the ongoing long-term biochemical experimental investigations, and results from more recent techniques such as protein localization by green fluorescent protein-fusion immunofluorescence or double-hybrid assay, have brought our understanding of the last stages of the peptidoglycan biosynthesis to an outstanding level that allows a broad outlook on the properties of these enzymes. Details are emerging regarding the interaction between the peptidoglycan-synthesizing PBPs and the peptidoglycan, their mesh net-like product that surrounds and protects bacteria. This review focuses on the detailed structure of PBPs and their implication in peptidoglycan synthesis, maturation and recycling. An overview of the content in PBPs of some bacteria is provided with an emphasis on comparing the biochemical properties of homologous PBPs (orthologues) belonging to different bacteria.

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Crossref · 10.1111/j.1574-6976.2008.00105.x

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Metadata

Authors
Sauvage, E., Kerff, F., Terrak, M., Ayala, J. A., & Charlier, P.
Venue
FEMS Microbiology Reviews
Published
2008-03
Volume
32
Issue
2
Pages
234-258
ISSN
  • 0168-6445 (ISSN-L)
  • 1574-6976
OpenAlex
W2105999876
Cited by
1,317
References
123
FWCI
26.01
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: The penicillin-binding proteins: structure and role in peptidoglycan biosynthesis. https://app.cochat.ai/papers/10.1111/j.1574-6976.2008.00105.x
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Sauvage, E., Kerff, F., Terrak, M., Ayala, J. A., & Charlier, P. (2008). The penicillin-binding proteins: structure and role in peptidoglycan biosynthesis. FEMS Microbiology Reviews. https://doi.org/10.1111/j.1574-6976.2008.00105.x

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