The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
Generation of multiple cell types in Bacillus subtilis
Open accessAbstract
Bacillus subtilis is a Gram-positive bacterium that is well known for its ability to differentiate into metabolically inactive spores that are highly resistant to environmental stresses. In fact, populations of genetically identical B. subtilis comprise numerous distinct cell types. In addition to spores, cells can become genetically competent, motile, produce extracellular matrix or degradative enzymes, or secrete toxins that allow them to cannibalize their neighbors. Many of the cell fates listed above appear to be mutually exclusive. In this review, we discuss how individual cells within a population control their gene expression to ensure that proper regulation of differentiation occurs. These different cell fates are regulated by an intricate network that relies primarily on the activity of three major transcriptional regulators: Spo0A, DegU, and ComK. While individual cells must choose distinct cell fates, the population as a whole exhibits a spectrum of phenotypes whose diversity may increase fitness.
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Cites
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Fruiting body formation by Bacillus subtilis
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An excitable gene regulatory circuit induces transient cellular differentiation
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Sporulation of Bacillus subtilis
Piggot, P. J., & Hilbert, D. W. (2004) · Current Opinion in Microbiology · doi:10.1016/j.mib.2004.10.001 · Cited by 710
Cell Death in Pseudomonas aeruginosa Biofilm Development
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A master regulator for biofilm formation by Bacillus subtilis
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Self-citationCannibalism by sporulating bacteria.
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Control of cell fate by the formation of an architecturally complex bacterial community
Vlamakis, H., Aguilar, C., Losick, R., & Kolter, R. (2008) · Genes & Development · doi:10.1101/gad.1645008 · Cited by 545
Self-citationSingle-Cell Microbiology: Tools, Technologies, and Applications
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Cited by
Condition-Dependent Transcriptome Reveals High-Level Regulatory Architecture in Bacillus subtilis
Nicolas, P., Mäder, U., Dervyn, E., Rochat, T., Leduc, A., Pigeonneau, N., Bidnenko, E., Marchadier, E., Hoebeke, M., Aymerich, S., et al. (2012) · Science · doi:10.1126/science.1206848 · Cited by 910
d -Amino Acids Trigger Biofilm Disassembly
Kolodkin-Gal, I., Romero, D., Cao, S., Clardy, J., Kolter, R., & Losick, R. (2010) · Science · doi:10.1126/science.1188628 · Cited by 874
Self-citationMicrobial single-cell RNA sequencing by split-pool barcoding
Kuchina, A., Brettner, L. M., Paleologu, L., Roco, C. M., Rosenberg, A. B., Carignano, A., Kibler, R., Hirano, M., DePaolo, R. W., & Seelig, G. (2021) · Science · doi:10.1126/science.aba5257 · Cited by 340
Mixed‐species biofilm compromises wound healing by disrupting epidermal barrier function
Roy, S., Elgharably, H., Sinha, M., Ganesh, K., Chaney, S., Mann, E., Miller, C., Khanna, S., Bergdall, V. K., Powell, H. M., et al. (2014) · The Journal of Pathology · doi:10.1002/path.4360 · Cited by 208
“In the biofilm form, bacteria are encased within an extracellular polymeric substance (EPS) and become recalcitrant to antimicrobials and host defences, posing a rapidly escalating threat to human health [2].”
BackgroundRyall, B., Eydallin, G., & Ferenci, T. (2012) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.05028-11 · Cited by 160
Metadata
- Authors
- Lopez, D., Vlamakis, H., & Kolter, R.
- Venue
- FEMS Microbiology Reviews
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-01
- Volume
- 33
- Issue
- 1
- Pages
- 152-163
- ISSN
- 0168-6445 (ISSN-L)
- 1574-6976
- OpenAlex
- W1991642577
- Cited by
- 381
- References
- 66
- FWCI
- 8.44
- Type
- journal article
- Language
- en
- Open access
- bronze
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