The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Bistability in bacteria
Abstract
Summary: Gene expression in bacteria is traditionally studied from the average behaviour of cells in a population, which has led to the assumption that under a particular set of conditions all cells express genes in an approximately uniform manner. The advent of methods for visualizing gene expression in individual cells reveals, however, that populations of genetically identical bacteria are sometimes heterogeneous, with certain genes being expressed in a non‐uniform manner across the population. In some cases, heterogeneity is manifested by the bifurcation into distinct subpopulations, and we adopt the common usage, referring to this phenomenon as bistability. Here we consider four cases of bistability, three from Bacillus subtilis and one from Escherichia coli, with an emphasis on random switching mechanisms that generate alternative cell states and the biological significance of phenotypic heterogeneity. A review describing additional examples of bistability in bacteria has been published recently.
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Citations
Cites
Bacterial Persistence as a Phenotypic Switch
Balaban, N. Q., Merrin, J., Chait, R., Kowalik, L., & Leibler, S. (2004) · Science · doi:10.1126/science.1099390 · Cited by 2,952 · cited 2×
“Importantly, experiments with hip mutants have revealed that a small number of cells in the population spontaneously enter (and later exit) a state of no or slow growth and do so prior to drug treatment (Balaban et al., 2004).”
BackgroundIntrinsic and extrinsic contributions to stochasticity in gene expression
Swain, P. S., Elowitz, M. B., & Siggia, E. D. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.162041399 · Cited by 1,661
MicroRNAs acting in a double-negative feedback loop to control a neuronal cell fate decision
Johnston, R. J., Chang, S., Etchberger, J. F., Ortiz, C. O., & Hobert, O. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505530102 · Cited by 276
Cited by
Persister cells, dormancy and infectious disease
Lewis, K. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1557 · Cited by 2,052
Lewis, K. (2010) · Annual Review of Microbiology · doi:10.1146/annurev.micro.112408.134306 · Cited by 1,858
Noise in Gene Expression Determines Cell Fate in Bacillus subtilis
Maamar, H., Raj, A., & Dubnau, D. (2007) · Science · doi:10.1126/science.1140818 · Cited by 663
Self-citationA Stochastic Single-Molecule Event Triggers Phenotype Switching of a Bacterial Cell
Choi, P. J., Cai, L., Frieda, K., & Xie, X. S. (2008) · Science · doi:10.1126/science.1161427 · Cited by 438
The sporulation transcription factor Spo0A is required for biofilm development in Bacillus subtilis
Hamon, M. A., & Lazazzera, B. A. (2001) · Molecular Microbiology · doi:10.1046/j.1365-2958.2001.02709.x · Cited by 444
Metadata
- Authors
- Dubnau, D., & Losick, R.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 2006-06-22
- Volume
- 61
- Issue
- 3
- Pages
- 564-572
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W2161251399
- Cited by
- 726
- References
- 3
- FWCI
- 16.21
- Type
- journal article
- Language
- en
- Open access
- closed
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