Natural functions of lipopeptides from Bacillus and Pseudomonas : more than surfactants and antibiotics
Open accessAbstract
Lipopeptides constitute a structurally diverse group of metabolites produced by various bacterial and fungal genera. In the past decades, research on lipopeptides has been fueled by their antimicrobial, antitumour, immunosuppressant and surfactant activities. However, the natural functions of lipopeptides in the lifestyles of the producing microorganisms have received considerably less attention. The substantial structural diversity of lipopeptides suggests that these metabolites have different natural roles, some of which may be unique to the biology of the producing organism. This review gives a detailed overview of the versatile functions of lipopeptides in the biology of Pseudomonas and Bacillus species, and highlights their role in competitive interactions with coexisting organisms, including bacteria, fungi, oomycetes, protozoa, nematodes and plants. Their functions in cell motility, leading to colonization of novel habitats, and in the formation and development of highly structured biofilms are discussed in detail. Finally, this review provides an update on lipopeptide detection and discovery as well as on novel regulatory mechanisms and genes involved in lipopeptide biosynthesis in these two bacterial genera.
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Lipopeptides produced by Pseudomonas and Bacillus play a crucial role in biofilm formation and microbial competition, enhancing bioremediation efficiency.
“lipopeptides produced by Pseudomonas and Bacillus play a crucial role in biofilm formation and microbial competition, which enhances bioremediation efficiency [184,291].”
From Harnessing bacterial consortia for effective bioremediation: targeted removal of heavy metals, hydrocarbons, and persistent pollutants (2025) · cites this paper as [291]
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Research works printed but not linked: 4
- Adam A (2008) Elicitation de la résistance systémique induite chez la tomate et le concombre et activation de la voie de la lipoxygénase par des rhizobactéries non-pathoge `nes. PhD Thesis, University of Lie `ge, Belgium.
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- Authors
- Raaijmakers, J. M., De Bruijn, I., Nybroe, O., & Ongena, M.
- Affiliations
- Wageningen University & Research (NL)
- University of Copenhagen (DK)
- University of Liège (BE)
- Corresponding author
- Raaijmakers, Jos M.
- Venue
- FEMS Microbiology Reviews
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-11
- Volume
- 34
- Issue
- 6
- Pages
- 1037-1062
- ISSN
- 0168-6445 (ISSN-L)
- 1574-6976
- OpenAlex
- W2166501045
- Cited by
- 1,131
- References
- 0
- Citations by year
- 2026: 73 · 2025: 77 · 2024: 89 · 2023: 86 · 2022: 80 · 2021: 103 · 2020: 74 · 2019: 107 · 2018: 72 · 2017: 74 · 2016: 72 · 2015: 61 · 2014: 53 · 2013: 47 · 2012: 32
- FWCI
- 3.91
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEMS Microbiology Reviews (publishedVersion)
- PubMed (publishedVersion)
- Socio-Environmental Systems Modeling (acceptedVersion)
- ORBi (University of Liège) (submittedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- Stichting voor de Technische Wetenschappen
- Topics
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Keywords
- lipopeptides, Bacillus, Pseudomonas, bacterial competition, biofilm formation, cell motility, bacterial colonization, lipopeptide biosynthesis, natural products, surfactants, antibiotics, oomycete, protozoa, nematodes, plant interactions
- MeSH terms
- Anti-Bacterial Agents, Bacillus, Bacterial Adhesion, Bacterial Proteins, Pseudomonas, Surface-Active Agents, Gene Expression Regulation, Bacterial, Biofilms, Lipopeptides
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