The DOI matches its Crossref record; 82 of the 82 references it cites were found in a registry or an index.
Polyamine metabolism and cancer
Open accessAbstract
Polyamines are aliphatic cations present in all cells. In normal cells, polyamine levels are intricately controlled by biosynthetic and catabolic enzymes. The biosynthetic enzymes are ornithine decarboxylase, S‐adenosylmethionine decarboxylase, spermidine synthase, and spermine synthase. The catabolic enzymes include spermidine/spermine acetyltransferase, flavin containing polyamine oxidase, copper containing diamine oxidase, and possibly other amine oxidases. Multiple abnormalities in the control of polyamine metabolism and uptake might be responsible for increased levels of polyamines in cancer cells as compared to that of normal cells. This review is designed to look at the current research in polyamine biosynthesis, catabolism, and transport pathways, enumerate the functions of polyamines, and assess the potential for using polyamine metabolism or function as targets for cancer therapy.
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Cites
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Polyamine metabolism and function
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Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy.
Pegg, A. E. (1988) · PubMed · Cited by 1,528
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The role of the cyclin-dependent kinase inhibitor p21 in apoptosis.
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Polyamines in cell growth and cell death: molecular mechanisms and therapeutic applications
Thomas*, T., & Thomas, T. J. (2001) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000852 · Cited by 859
Self-citationThe Chemical and Biological Versatility of Riboflavin
Massey, V. (2000) · Biochemical Society Transactions · doi:10.1042/0300-5127:0280283 · Cited by 751
Polyamines as Targets for Therapeutic Intervention
Marton, L. J., & Pegg, A. E. (1995) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.35.040195.000415 · Cited by 619
Polyamines as Targets for Therapeutic Intervention
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Afaq, F., Saleem, M., Krueger, C. G., Reed, J. D., & Mukhtar, H. (2005) · International Journal of Cancer · doi:10.1002/ijc.20587 · Cited by 439
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Metadata
- Authors
- Thomas, T., & Thomas, T. J.
- Venue
- Journal of Cellular and Molecular Medicine
- Publisher
- Wiley
- Published
- 2003-04
- Volume
- 7
- Issue
- 2
- Pages
- 113-126
- ISSN
- 1582-1838 (ISSN-L)
- 1582-4934
- OpenAlex
- W1965913407
- Cited by
- 332
- References
- 82
- FWCI
- 7.40
- Type
- journal article
- Language
- en
- Open access
- bronze
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
