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Effects of methylation on a synthetic polynucleotide: the B--Z transition in poly(dG-m5dC).poly(dG-m5dC).
Open accessAbstract
We have compared the behavior in solution of the synthetic polynucleotide poly(dG-m5dC).poly(dG-m5dC) with that of the unmethylated polynucleotide poly(dG-dC).poly(dG-dC). In solutions containing high concentrations of salt, poly(dG-dC).poly(dG-dC) is known to exhibit altered circular dichroic and absorption spectra correlated with formation of a left-handed Z DNA structure. Poly(dG-m5dC).poly(dG-m5dC) behaves similarly, but the spectral transition from the B to the Z form occurs at much lower salt concentrations, close to usual physiological conditions. Divalent and polyvalent ions are particularly effective: The B--Z transition of poly(dG-m5dC).(dG-m5dC) can be induced at a Mg2+ concentration three orders of magnitude lower than that required for the unmethylated polymer. We have also studied mixed copolymers containing both dC and m5dC. Our results suggest that the sequence m5dC-dG, which occurs in eukaryotic DNA, can have a disproportionately large effect on the B--Z transition.
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Cited by
Instability of a 550-Base Pair DNA Segment and Abnormal Methylation in Fragile X Syndrome
Oberlé, I., Rousseau, F., Heitz, D., Kretz, C., Devys, D., Hanauer, A., Boué, J., Bertheas, M. F., & Mandel, J. L. (1991) · Science · doi:10.1126/science.252.5009.1097 · Cited by 1,499
The structure of DNA in a nucleosome.
Hayes, J. J., Tullius, T. D., & Wolffe, A. P. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.19.7405 · Cited by 353
Polyamine metabolism and cancer
Thomas, T., & Thomas, T. J. (2003) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2003.tb00210.x · Cited by 332
Role of DNA methylation in the regulation of transcription
Eden, S., & Cedar, H. (1994) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(05)80052-8 · Cited by 320
Hemin-mediated DNA strand scission.
Aft, R. L., & Mueller, G. C. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44341-9 · Cited by 123
Metadata
- Authors
- Behe, M., & Felsenfeld, G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1981-03
- Volume
- 78
- Issue
- 3
- Pages
- 1619-1623
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1990933742
- Cited by
- 882
- References
- 0
- FWCI
- 33.68
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Effects of methylation on a synthetic polynucleotide: the B--Z transition in poly(dG-m5dC).poly(dG-m5dC). https://app.cochat.ai/papers/10.1073/pnas.78.3.1619
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- Behe, M., & Felsenfeld, G. (1981). Effects of methylation on a synthetic polynucleotide: the B--Z transition in poly(dG-m5dC).poly(dG-m5dC). Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.78.3.1619
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