The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
L-selectin: mechanisms and physiological significance of ectodomain cleavage
Open accessAbstract
L-selectin is a cell adhesion molecule consisting of a large, highly glycosylated, extracellular domain, a single spanning transmembrane domain and a small cytoplasmic tail. It is expressed on most leukocytes and is involved in their rolling on inflamed vascular endothelium prior to firm adhesion and transmigration. It is also required for the constitutive trafficking of lymphocytes through secondary lymphoid organs. Like most adhesion molecules, L-selectin function is regulated by a variety of mechanisms including gene transcription, post-translational modifications, association with the actin cytoskeleton, and topographic distribution. In addition, it is rapidly downregulated by proteolytic cleavage near the cell surface by ADAM-17 (TACE) and at least one other "sheddase". This process of "ectodomain shedding" results in the release of most of the extracellular portion of L-selectin from the cell surface while retaining the cytoplasmic, transmembrane, and eleven amino acids of the extracellular domain on the cell. This review will examine the mechanism(s) of L-selectin ectodomain shedding and discuss the physiological implications.
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A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells
Black, R. A., Rauch, C. T., Kozlosky, C. J., Peschon, J. J., Slack, J. L., Wolfson, M. F., Castner, B. J., Stocking, K. L., Reddy, P., Srinivasan, S., et al. (1997) · Nature · doi:10.1038/385729a0 · Cited by 3,149
Garton, K. J., Gough, P. J., Philalay, J., Wille, P. T., Blobel, C. P., Whitehead, R. H., Dempsey, P. J., & Raines, E. W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305877200 · Cited by 282
Cited by
Tacke, F., Alvarez, D., Kaplan, T. J., Jakubzick, C., Spanbroek, R., Llodra, J., Garin, A., Liu, J., Mack, M., van Rooijen, N., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci28549 · Cited by 1,323
MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1
Harris, T. A., Yamakuchi, M., Ferlito, M., Mendell, J. T., & Lowenstein, C. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707493105 · Cited by 1,010
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Khokha, R., Murthy, A., & Weiss, A. (2013) · Nature reviews. Immunology · doi:10.1038/nri3499 · Cited by 552
ADAM17: a molecular switch to control inflammation and tissue regeneration
Scheller, J., Chalaris, A., Garbers, C., & Rose-John, S. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.05.005 · Cited by 526
Metadata
- Authors
- Smalley, D. M., & Ley, K.
- Venue
- Journal of Cellular and Molecular Medicine
- Publisher
- Wiley
- Published
- 2005-04
- Volume
- 9
- Issue
- 2
- Pages
- 255-266
- ISSN
- 1582-1838 (ISSN-L)
- 1582-4934
- OpenAlex
- W2128141580
- Cited by
- 233
- References
- 2
- FWCI
- 11.58
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Smalley, D. M., & Ley, K. (2005). L-selectin: mechanisms and physiological significance of ectodomain cleavage. Journal of Cellular and Molecular Medicine. https://doi.org/10.1111/j.1582-4934.2005.tb00354.x
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