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Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology
Open accessAbstract
Down-regulation of protein phosphatase 2A (PP2A) is thought to play a critical role in tau hyperphosphorylation in Alzheimer's disease (AD). In vitro phosphorylation of PP2A catalytic subunit at Y307 efficiently inactivates PP2A. A specific antibody against phosphorylated (p) PP2A (Y307) (PP2Ac-Yp307) was used to investigate possible PP2A down-regulation by known pathophysiological changes associated with AD, such as Abeta accumulation and oestrogen deficiency. Immunohistochemistry and immunofluorescence confocal microscopy showed an aberrant accumulation of PP2Ac-Yp307 in neurons that bear pretangles or tangles in the susceptible brain regions, such as the entorhinal cortical cortex and the hippocampus. Experimentally, increased PP2Ac-Yp307 was observed in mouse N2a neuroblastoma cells that stably express the human amyloid precursor protein with Swedish mutation (APPswe) compared with wild-type, and in the brains of transgenic APPswe/ presenilin (PS1, A246E) mice, which corresponded to the increased tau phosphorylation. Treating N2a cells with Abeta25-35 mimicked the changes of PP2Ac-Yp307 and tau phosphorylation in N2a APPswe cells. Knockout of oestrogen receptor (ER) alpha or ERbeta gave similar changes of PP2Ac-Yp307 level and tau phosphorylation in the mouse brain. Taken together, these findings suggest that increased PP2A phosphorylation (Y307) can be mediated by Abeta deposition or oestrogen deficiency in the AD brain, and consequently compromise dephosphorylation of abnormally hyperphosphorylated tau, and lead to neurofibrillary tangle formation.
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“We have reported that Y307 phosphorylation of PP2A was increased in AD and contributed to PP2A inhibition (Liu et al., 2008).”
From CIP2A Causes Tau/APP Phosphorylation, Synaptopathy, and Memory Deficits in Alzheimer’s Disease (2018) · cites this paper as Liu et al., 2008
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Metadata
- Authors
- Liu, R., Zhou, X. ‐., Tanila, H., Bjorkdahl, C., Wang, J. ‐., Guan, Z. ‐., Cao, Y., Gustafsson, J. ‐., Winblad, B., & Pei, J. ‐.
- Affiliations
- Karolinska Institutet (SE)
- University of Eastern Finland (FI)
- Huazhong University of Science and Technology (CN)
- Guiyang Medical University (CN)
- Corresponding author
- Liu, R.
- Venue
- Journal of Cellular and Molecular Medicine
- Publisher
- Wiley
- Published
- 2008-01
- Volume
- 12
- Issue
- 1
- Pages
- 241-257
- ISSN
- 1582-1838 (ISSN-L)
- 1582-4934
- PMC
- PMC3823485
- OpenAlex
- W1995042713
- Cited by
- 125
- References
- 41
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 5 · 2022: 8 · 2021: 5 · 2020: 8 · 2019: 8 · 2018: 8 · 2017: 4 · 2016: 3 · 2015: 3 · 2014: 11 · 2013: 10 · 2012: 12
- FWCI
- 8.35
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Journal of Cellular and Molecular Medicine (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- protein phosphatase 2A, Alzheimer's disease, neurofibrillary tangles, tau hyperphosphorylation, amyloid-beta, estrogen deficiency, estrogen receptor alpha, estrogen receptor beta, APPswe, presenilin 1, entorhinal cortex, hippocampus, N2a cells
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Animals, Antibodies, Monoclonal, Estrogens, Female, Humans, Male, Mice, Transgenic, Mutation, Neuroblastoma, Neurons, Phosphorylation, Transfection, Tyrosine, Amyloid beta-Protein Precursor, Neurofibrillary Tangles, tau Proteins, Microscopy, Confocal, Fluorescent Antibody Technique, Indirect, Estrogen Receptor alpha, Estrogen Receptor beta, Mice, Protein Phosphatase 2
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