Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology

Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

Janssens, V., & Goris, J. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3530417 · Cited by 1,927

Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP

Lewis, J., Dickson, D. W., Lin, W.-L., Chisholm, L., Corral, A., Jones, G., Yen, S.-H., Sahara, N., Skipper, L., Yager, D., et al. (2001) · Science · doi:10.1126/science.1058189 · Cited by 1,611

Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Aβ42 Fibrils

Götz, J., Chen, F., van Dorpe, J., & Nitsch, R. M. (2001) · Science · doi:10.1126/science.1062097 · Cited by 1,526

Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo

Borchelt, D. R., Thinakaran, G., Eckman, C. B., Lee, M. K., Davenport, F., Ratovitsky, T., Prada, C.-M., Kim, G., Seekins, S., Yager, D., et al. (1996) · Neuron · doi:10.1016/s0896-6273(00)80230-5 · Cited by 1,478

Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

Janssens, V., & Goris, J. (2001) · Biochemical Journal · doi:10.1042/bj3530417 · Cited by 1,392

Aβ Immunotherapy Leads to Clearance of Early, but Not Late, Hyperphosphorylated Tau Aggregates via the Proteasome

Oddo, S., Billings, L., Kesslak, J. P., Cribbs, D. H., & LaFerla, F. M. (2004) · Neuron · doi:10.1016/j.neuron.2004.07.003 · Cited by 780

Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation

Chen, J., Martin, B. L., & Brautigan, D. L. (1992) · Science · doi:10.1126/science.1325671 · Cited by 601

Phosphoprotein Phosphatase Activities in Alzheimer Disease Brain

Gong, C., Singh, T. J., Grundke‐Iqbal, I., & Iqbal, K. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb03603.x · Cited by 527

Block of Long-Term Potentiation by Naturally Secreted and Synthetic Amyloid β-Peptide in Hippocampal Slices Is Mediated via Activation of the Kinases c-Jun N-Terminal Kinase, Cyclin-Dependent Kinase 5, and p38 Mitogen-Activated Protein Kinase as well as Metabotropic Glutamate Receptor Type 5

Wang, Q., Walsh, D. M., Rowan, M. J., Selkoe, D. J., & Anwyl, R. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1633-03.2004 · Cited by 437

Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity.

Takashima, A., Noguchi, K., Sato, K., Hoshino, T., & Imahori, K. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.16.7789 · Cited by 385

Protein phosphatase 2A: a panoply of enzymes

Virshup, D. M. (2000) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)00074-5 · Cited by 330

Gender differences in the amount and deposition of amyloidβ in APPswe and PS1 double transgenic mice

Wang, J., Tanila, H., Puoliväli, J., Kadish, I., & Groen, T. V. (2003) · Neurobiology of Disease · doi:10.1016/j.nbd.2003.08.009 · Cited by 316

Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease

An, W.-L., Cowburn, R. F., Li, L., Braak, H., Alafuzoff, I., Iqbal, K., Iqbal, I.-G., Winblad, B., & Pei, J.-J. (2003) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63687-5 · Cited by 312

Lack of Neurodegeneration in Transgenic Mice Overexpressing Mutant Amyloid Precursor Protein Is Associated with Increased Levels of Transthyretin and the Activation of Cell Survival Pathways

Stein, T. D., & Johnson, J. A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-17-07380.2002 · Cited by 290

PP2A mRNA Expression Is Quantitatively Decreased in Alzheimer's Disease Hippocampus

Vogelsberg-Ragaglia, V., Schuck, T., Trojanowski, J. Q., & Lee, V. M.-Y. (2001) · Experimental Neurology · doi:10.1006/exnr.2001.7630 · Cited by 281

Tyrosine phosphorylation of protein phosphatase 2A in response to growth stimulation and v-src transformation of fibroblasts.

Chen, J., Parsons, S., & Brautigan, D. L. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37144-2 · Cited by 259

Estrogen-Induced Activation of the Mitogen-Activated Protein Kinase Cascade in the Cerebral Cortex of Estrogen Receptor-α Knock-Out Mice

Singh, M., Sétáló, G., Guan, X., Frail, D. E., & Toran‐Allerand, C. D. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-05-01694.2000 · Cited by 250

Altered Expression Levels of the Protein Phosphatase 2A ABαC Enzyme Are Associated with Alzheimer Disease Pathology

Sontag, E., Luangpirom, A., Hladik, C., Mudrak, I., Ogris, E., Speciale, S., & White, C. L. (2004) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/63.4.287 · Cited by 228

Estrogen receptor (ER)β knockout mice reveal a role for ERβ in migration of cortical neurons in the developing brain

Wang, L., Andersson, S., Warner, M. N., & Gustafsson, J.-Α. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.242735799 · Cited by 222

Up-regulation of inhibitors of protein phosphatase-2A in Alzheimer’s disease

Tanimukai, H., Grundke-Iqbal, I., & Iqbal, K. (2005) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)62486-8 · Cited by 220

Estrogen Receptor Protein Interaction with Phosphatidylinositol 3-Kinase Leads to Activation of Phosphorylated Akt and Extracellular Signal-Regulated Kinase 1/2 in the Same Population of Cortical Neurons: A Unified Mechanism of Estrogen Action

Mannella, P., & Brinton, R. D. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1443-06.2006 · Cited by 213

Reduced protein phosphatase 2A activity induces hyperphosphorylation and altered compartmentalization of tau in transgenic mice

Kins, S., Crameri, A., Evans, D. R. H., Hemmings, B. A., Nitsch, R. M., & Götz, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102621200 · Cited by 203

Downregulation of Protein Phosphatase 2A Carboxyl Methylation and Methyltransferase May Contribute to Alzheimer Disease Pathogenesis

Sontag, E., Hladik, C. L., Montgomery, L. G., Luangpirom, A., Mudrak, I., Ogris, E., & White, C. L. (2004) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/63.10.1080 · Cited by 195

Role of protein kinase B in Alzheimer's neurofibrillary pathology

Pei, J.-J., Khatoon, S., An, W., Nordlinder, M., Tanaka, T., Braak, H., Tsujio, I., Takeda, M., Alafuzoff, I. I., Winblad, B. G., et al. (2002) · Acta Neuropathologica · doi:10.1007/s00401-002-0657-y · Cited by 169

Increased MAP kinase activity in Alzheimer's and Down syndrome but not in schizophrenia human brain

SWATTON, J. E., Sellers, L. A., Faull, R. L. M., Holland, A. J., Iritani, S., & Bahn, S. (2004) · European Journal of Neuroscience · doi:10.1111/j.0953-816x.2004.03365.x · Cited by 158

Activation of the ERK and JNK signaling pathways caused by neuron-specific inhibition of PP2A in transgenic mice

Kins, S., Kurosinski, P., Nitsch, R. M., & Götz, J. (2003) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63444-x · Cited by 155

Involvement of Insulin/Phosphoinositide 3-Kinase/Akt Signal Pathway in 17β-Estradiol-mediated Neuroprotection

Yu, X., Rajala, R. V. S., McGinnis, J. F., Li, F., Anderson, R. E., Yan, X., Li, S., Elias, R. V., Knapp, R. R., Zhou, X., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313283200 · Cited by 143

Okadaic-Acid-Induced Inhibition of Protein Phosphatase 2A Produces Activation of Mitogen-Activated Protein Kinases ERK1/2, MEK1/2, and p70 S6, Similar to That in Alzheimer's Disease

Pei, J.-J., Gong, C., An, W., Winblad, B. G., Cowburn, R. F., Grundke, I., & Iqbal, K. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63445-1 · Cited by 142

Tau protein I is essential for amyloid β-protein iduced neurotoxicity

Takashima, A. (1993) · Medical Entomology and Zoology · Cited by 125

Protein phosphatase 2A is reversibly modified by methyl esterification at its C-terminal leucine residue in bovine brain.

Xie, H., & Clarke, S. G. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42124-7 · Cited by 123

Mutation of Tyr307 and Leu309 in the Protein Phosphatase 2A Catalytic Subunit Favors Association with the α4 Subunit Which Promotes Dephosphorylation of Elongation Factor-2

Chung, H., Nairn, A. C., Murata, K., & Brautigan, D. L. (1999) · Biochemistry · doi:10.1021/bi990902g · Cited by 90

Estrogen receptor β expression in the embryonic brain regulates development of calretinin-immunoreactive GABAergic interneurons

Fan, X., Warner, M. N., & Gustafsson, J.-Α. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609663103 · Cited by 84

Estrogen treatment improves spatial learning in APP + PS1 mice but does not affect beta amyloid accumulation and plaque formation

Heikkinen, T., Kalesnykas, G., Rissanen, A., Tapiola, T., Iivonen, S., Wang, J., Chaudhuri, J. D., Tanila, H., Miettinen, R. A., & Puoliväli, J. T. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.01.015 · Cited by 79

Protein Phosphatase 2A RegulatesbimExpression via the Akt/FKHRL1 Signaling Pathway in Amyloid-β Peptide-Induced Cerebrovascular Endothelial Cell Death

Yin, K., Hsu, C. Y., Hu, X.-Y., Chen, H., Chen, S.-W., Xu, J., & Lee, J. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.5103-05.2006 · Cited by 65

Flicking the switches: phosphorylation of serine/threonine protein phosphatases

Brautigan, D. L. (1995) · Seminars in Cancer Biology · doi:10.1006/scbi.1995.0028 · Cited by 65

Assessments of the accumulation severities of amyloid β-protein and hyperphosphorylated tau in the medial temporal cortex of control and Alzheimer's brains

Zhou, X., Li, X., Björkdahl, C., Sjögren, M. J. C., Alafuzoff, I. I., Soininen, H. S., Grundke, I., Iqbal, K., Winblad, B. G., & Pei, J.-J. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.01.006 · Cited by 65

Subcellular distribution of protein phosphatases and abnormally phosphorylated τ in the temporal cortex from Alzheimer's disease and control brains

Pei, J. ‐., Gong, C., Iqbal, K., Grundke, I., Wu, Q., Winblad, B. G., & Cowburn, R. F. (1998) · Journal of Neural Transmission · doi:10.1007/s007020050039 · Cited by 60

Phosphorylation of tau at THR212 and SER214 in human neuronal and glial cultures: The role of AKT

Pyo, H. K., Lovati, E., Pasinetti, G. M., & Ksiȩżak-Reding, H. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.05.036 · Cited by 40

Erratum to “Gender differences in the amount and deposition of amyloidβ in APPswe and PS1 double transgenic mice” [Neurobiol. Dis. 14 (2003) 318–327]

Wang, J., Tanila, H., Puoliväli, J. T., Kadish, I., & van Groen, T. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.02.006 · Cited by 34

Acute anoxia induces tau dephosphorylation in rat brain slices and its possible underlying mechanisms

Liu, R., Pei, J.-J., Wang, X., Zhou, X., Tian, Q., Winblad, B. G., & Wang, J. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03270.x · Cited by 31

Post-translational modifications of tau protein: Implications for Alzheimer's disease

Martin, L., Latypova, X., & Terro, F. (2011) · Neurochemistry International · doi:10.1016/j.neuint.2010.12.023 · Cited by 683

Abnormal Hyperphosphorylation of Tau: Sites, Regulation, and Molecular Mechanism of Neurofibrillary Degeneration

Wang, J., Xia, Y., Grundke, I., & Iqbal, K. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-129031 · Cited by 547

Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease

Liu, F., Shi, J., Tanimukai, H., Gu, J., Gu, J., Grundke-Iqbal, I., Iqbal, K., & Gong, C.-X. (2009) · Brain · doi:10.1093/brain/awp099 · Cited by 439

The Role of Tau in Alzheimer's Disease and Related Disorders

Medeiros, R., Baglietto‐Vargas, D., & LaFerla, F. M. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2010.00177.x · Cited by 484

Curcumin-primed exosomes potently ameliorate cognitive function in AD mice by inhibiting hyperphosphorylation of the Tau protein through the AKT/GSK-3β pathway

Wang, H., Sui, H., Zheng, Y., Jiang, Y., Shi, Y., Liang, J., & Zhao, L. (2019) · Nanoscale · doi:10.1039/c9nr01255a · Cited by 324

P3–300: Increased tyrosine 307 phosphorylation of protein phosphatase–2A correlates with tau associated pathologies in Alzheimer's disease

Liu, R., Björkdahl, C., Zhou, X., Alafuzoff, I. I., Soininen, H. S., Bogdanović, N., Iqbal, K., Grundke, I., Winblad, B., Wang, J., et al. (2006) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2006.05.1569

P3–301: Aβ mediates tau hyperphosphorylation via down–regulating PP2A in Alzheimer's disease

Zhou, X., Tanila, H., Liu, R., Winblad, B. G., & Pei, J.-J. (2006) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2006.05.1571 · Cited by 1

Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A

Zhou, X.-W., Gustafsson, J.-Α., Tanila, H., Björkdahl, C., Liu, R., Winblad, B. G., & Pei, J.-J. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.05.013 · Cited by 104

Reduced protein phosphatase 2A activity induces hyperphosphorylation and altered compartmentalization of tau in transgenic mice

Kins, S., Crameri, A., Evans, D. R. H., Hemmings, B. A., Nitsch, R. M., & Götz, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102621200 · Cited by 203

P4–037: PTPA reduces phosphorylated PP2A level with upregulation of protein tyrosine phosphatase 1B

Liu, G. (2013) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.05.1425