The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Identification of telocytes in skeletal muscle interstitium: implication for muscle regeneration
Open accessAbstract
Skeletal muscle interstitium is crucial for regulation of blood flow, passage of substances from capillaries to myocytes and muscle regeneration. We show here, probably, for the first time, the presence of telocytes (TCs), a peculiar type of interstitial (stromal) cells, in rat, mouse and human skeletal muscle. TC features include (as already described in other tissues) a small cell body and very long and thin cell prolongations—telopodes (Tps) with moniliform appearance, dichotomous branching and 3D‐network distribution. Transmission electron microscopy (TEM) revealed close vicinity of Tps with nerve endings, capillaries, satellite cells and myocytes, suggesting a TC role in intercellular signalling (via shed vesicles or exosomes). In situ immunolabelling showed that skeletal muscle TCs express c‐kit, caveolin‐1 and secrete VEGF. The same phenotypic profile was demonstrated in cell cultures. These markers and TEM data differentiate TCs from both satellite cells (e.g. TCs are Pax7 negative) and fibroblasts (which are c‐kit negative). We also described non‐satellite (resident) progenitor cell niche. In culture, TCs (but not satellite cells) emerge from muscle explants and form networks suggesting a key role in muscle regeneration and repair, at least after trauma.
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Citations
Cites
Asymmetric self-renewal and commitment of satellite stem cells in muscle
Kuang, S., Kuroda, K., Le Grand, F., & Rudnicki, M. A. (2007) · Cell · doi:10.1016/j.cell.2007.03.044 · Cited by 1,449 · cited 1×
“TCs might be involved in other signalling pathways as well, such as Wnt and Notch, involved in satellite cell fate regulation [64–66].”
BackgroundBrack, A. S., Conboy, I. M., Conboy, M. J., Shen, J., & Rando, T. A. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2007.10.006 · Cited by 682
Niche Regulation of Muscle Satellite Cell Self-Renewal and Differentiation
Kuang, S., Gillespie, M. A., & Rudnicki, M. A. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2007.12.012 · Cited by 507 · cited 1×
“Muscle satellite cells constitute a reservoir of muscle progenitors, which can both self-renew and, under proper stimulation, differentiate and migrate to replace functional myocytes [1, 67].”
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Cited by
Satellite Cells and the Muscle Stem Cell Niche
Yin, H., Price, F., & Rudnicki, M. A. (2013) · Physiological Reviews · doi:10.1152/physrev.00043.2011 · Cited by 2,166
Franceschi, C., Salvioli, S., Garagnani, P., de Eguileor, M., Monti, D., & Capri, M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00982 · Cited by 290
Cretoiu, S. M., & Popescu, L. M. (2014) · Biomolecular Concepts · doi:10.1515/bmc-2014-0029 · Cited by 267
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Metadata
- Authors
- Popescu, L. M., Manole, E., Şerboiu, C. S., Manole, C. G., Suciu, L. C., Gherghiceanu, M., & Popescu, B. O.
- Venue
- Journal of Cellular and Molecular Medicine
- Publisher
- Wiley
- Published
- 2011-05-30
- Volume
- 15
- Issue
- 6
- Pages
- 1379-1392
- ISSN
- 1582-1838 (ISSN-L)
- 1582-4934
- OpenAlex
- W2015877527
- Cited by
- 195
- References
- 3
- FWCI
- 7.52
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Popescu, L. M., Manole, E., Şerboiu, C. S., Manole, C. G., Suciu, L. C., Gherghiceanu, M., & Popescu, B. O. (2011). Identification of telocytes in skeletal muscle interstitium: implication for muscle regeneration. Journal of Cellular and Molecular Medicine. https://doi.org/10.1111/j.1582-4934.2011.01330.x
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