Senescence determines the fate of activated rat pancreatic stellate cells
Open accessAbstract
In chronic pancreatitis (CP), persistent activation of pancreatic stellate cells (PSC) converts wound healing into a pathological process resulting in organ fibrosis. Here, we have analysed senescence as a novel mechanism involved in the termination of PSC activation and tissue repair. PSC senescence was first studied in vitro by establishing long‐term cultures and by applying chemical triggers, using senescence‐associated β‐Galactosidase (SA β‐Gal) as a surrogate marker. Subsequently, susceptibility of PSC to immune cell‐mediated cytolysis was investigated employing cocultures. Using the model of dibutyltin dichloride‐induced CP in rats, appearance of senescent cells was monitored by immunohistochemistry and immunofluorescence, and correlated with the progression of tissue damage and repair, immune cell infiltration and fibrosis. The results indicated that long‐term culture and exposure of PSC to stressors (doxorubicin, H2O2 and staurosporine) induced senescence. Senescent PSC highly expressed CDKN 1A/p21, mdm2 and interleukin (IL)‐6, but displayed low levels of α‐smooth muscle actin. Senescence increased the susceptibility of PSC to cytolysis. In CP, the number of senescent cells correlated with the severity of inflammation and the extension of fibrosis. Areas staining positive for SA β‐Gal overlapped with regions of fibrosis and dense infiltrates of immune cells. Furthermore, a close physical proximity of immune cells and activated PSC was observed. We conclude that inflammation, PSC activation and cellular senescence are timely coupled processes which take place in the same microenvironment of the inflamed pancreas. Lymphocytes may play a dual‐specific role in pancreatic fibrogenesis, triggering both the initiation of wound healing by activating PSC, and its completion by killing senescent stellate cells.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Induction of a senescence programme limits fibrosis progression in the pancreas.
“Moreover, induction of a senescence programme limits fibrosis progression in the pancreas148.”
From Cellular senescence in ageing: from mechanisms to therapeutic opportunities (2021) · cites this paper as [148]
The Introduction (page unavailable) proposes a role for senescence in regulating pancreatic fibrogenesis, and the Discussion (page unavailable) describes it as a possible component of pancreatic wound healing. But the rat study reports that senescent cells correlated with the extent of fibrosis; it does not show that inducing senescence limits fibrosis progression in the pancreas. (LLM, conf=0.86)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Cellular senescence: when bad things happen to good cells
Campisi, J., & d'Adda di Fagagna, F. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2233 · Cited by 4,441 · see citing works
Senescence of activated stellate cells limits liver fibrosis
Krizhanovsky, V., Yon, M., Dickins, R. A., Hearn, S., Simon, J., Miething, C., Yee, H., Zender, L., & Lowe, S. W. (2008) · Cell · doi:10.1016/j.cell.2008.06.049 · Cited by 2,029 · see citing works
Senescence of Activated Stellate Cells Limits Liver Fibrosis
Krizhanovsky, V., Yon, M., Dickins, R. A., Hearn, S., Simon, J., Miething, C., Yee, H., Zender, L., & Lowe, S. W. (2008) · Cell · doi:10.1016/j.cell.2008.09.015 · Cited by 2,027
The signals and pathways activating cellular senescence
Ben-Porath, I., & Weinberg, R. A. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.10.013 · Cited by 1,046 · see citing works
p21WAF1/Cip1: more than a break to the cell cycle?
Dotto, G. P. (2000) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(00)00019-6 · Cited by 474 · see citing works
Froeling, F. E. M., Feig, C., Chelala, C., Dobson, R., Mein, C. A., Tuveson, D. A., Clevers, H. C., Hart, I. R., & Kocher, H. M. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.06.047 · Cited by 421 · see citing works
StellaTUM: current consensus and discussion on pancreatic stellate cell research
Erkan, M., Adler, G., Apte, M. V., Bachem, M. G., Buchholz, M., Detlefsen, S., Esposito, I., Frieß, H., Gress, T. M., Habisch, H., et al. (2011) · Gut · doi:10.1136/gutjnl-2011-301220 · Cited by 411 · see citing works
Self-citationAstle, M. V., Hannan, K. M., Ng, P. Y., Lee, R. S., George, A. J., Hsu, A. K., Haupt, Y., Hannan, R. D., & Pearson, R. B. (2012) · Oncogene · doi:10.1038/onc.2011.394 · Cited by 295 · see citing works
Paradoxical suppression of cellular senescence by p53
Demidenko, Z. N., Korotchkina, L. G., Gudkov, A. V., & Blagosklonny, M. V. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002298107 · Cited by 273 · see citing works
McCarroll, J. A., Phillips, P. A., Santucci, N., Pirola, R. C., Wilson, J. S., & Apte, M. V. (2005) · Gut · doi:10.1136/gut.2005.064543 · Cited by 147 · see citing works
Jaster, R., Sparmann, G., Emmrich, J., & Liebe, S. (2002) · Gut · doi:10.1136/gut.51.4.579 · Cited by 142 · see citing works
Self-citationKrizhanovsky, V., Xue, W., Zender, L., Yon, M., Hernando, E., & Lowe, S. W. (2008) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2008.73.048 · Cited by 138 · see citing works
Pancreatic fibrosis in experimental pancreatitis induced by dibutyltin dichloride
Sparmann, G. H., Merkord, J., Jaschke, A., Nizze, H., Jonas, L., Löhr, M. J., LIEBE, S., & Emmrich, J. (1997) · Gastroenterology · doi:10.1016/s0016-5085(97)70049-0 · Cited by 137 · see citing works
Self-citationRickmann, M., Vaquero, E. C., Malagelada, J. R., & Molero, X. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.107 · Cited by 102 · see citing works
Spallarossa, P., Altieri, P., Barisione, C., Passalacqua, M., Aloi, C., Fugazza, G., Frassoni, F., Podestà, M., Canepa, M., Ghigliotti, G., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015583 · Cited by 81 · see citing works
Prevention of premature senescence requires JNK regulation of Bcl-2 and reactive oxygen species
Lee, J. J., Lee, J. H., Ko, Y. G., Hong, S., & Js, L. (2009) · Oncogene · doi:10.1038/onc.2009.355 · Cited by 66 · see citing works
Acute Interstitial Pancreatitis in Rats Induced by Dibutyltin Dichloride (DBTC)
Merkord, J., Jonas, L., Weber, H., Kröning, G., Nizze, H., & Hennighausen, G. (1997) · Pancreas · doi:10.1097/00006676-199711000-00010 · Cited by 62 · see citing works
Self-citationJaster, R., Lichte, P., Fitzner, B., Brock, P., Glass, A. S., Karopka, T., Gierl, L., Koczan, D., Thiesen, H., Sparmann, G. H., et al. (2005) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2005.tb00497.x · Cited by 59 · see citing works
Self-citationCrucial role of fibrogenesis in pancreatic diseases
Jaster, R., & Emmrich, J. (2008) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2007.10.004 · Cited by 58 · see citing works
Self-citationMato, E., Lucas, M., Pétriz, J., Gomis, R., & Novials, A. (2009) · Biochemical Journal · doi:10.1042/bj20081466 · Cited by 55 · see citing works
Michalski, C. W., Gorbachevski, A., Erkan, M., Reiser–Erkan, C., Deucker, S., Bergmann, F., Giese, T., Weigand, M. A., Giese, N. A., Frieß, H., et al. (2007) · Journal of Translational Medicine · doi:10.1186/1479-5876-5-63 · Cited by 45 · see citing works
Sparmann, G. H., Behrend, S., Merkord, J., Kleine, H., Graser, E., Ritter, T., Liebe, S., & Emmrich, J. (2001) · Digestive Diseases and Sciences · doi:10.1023/a:1010689117772 · Cited by 40 · see citing works
Manapov, F., Muller, P., & Rychly, J. (2005) · Gut · doi:10.1136/gut.2003.036491 · Cited by 32 · see citing works
Fitzner, B., Brock, P., Holzhueter, S.-A., Nizze, H., Sparmann, G. H., Emmrich, J., Liebe, S., & Jaster, R. (2008) · Digestive Diseases and Sciences · doi:10.1007/s10620-008-0366-z · Cited by 29 · see citing works
Self-citationMdm2 links genotoxic stress and metabolism to p53
Wang, Z., & Li, B. (2010) · Protein & Cell · doi:10.1007/s13238-010-0140-9 · Cited by 29 · see citing works
Inhibition of lymphocyte apoptosis by pancreatic stellate cells: impact of interleukin-15
Sparmann, G. H., Glass, A. S., Brock, P., Jaster, R., Koczan, D., Thiesen, H., Liebe, S., & Emmrich, J. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00483.2004 · Cited by 25 · see citing works
Self-citationApoptosis in activated rat pancreatic stellate cells
Klonowski-Stumpe, H., Fischer, R., Reinehr, R., Luthen, R. E., & Häussinger, D. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00073.2002 · Cited by 25 · see citing works
Pancreatic stellate cells can form new β-like cells
Docherty, K. (2009) · Biochemical Journal · doi:10.1042/bj20090779 · Cited by 10 · see citing works
Yang, M., Zhang, M., Chen, J., Mukherjee, R., Zhang, L., Lin, S., & Gu, Y. (2010) · American Journal of Nephrology · doi:10.1159/000304289 · Cited by 10 · see citing works
Interleukin-4 gene transfer into rat pancreas by recombinant adenovirus
Brock, P., Sparmann, G. H., Ritter, T., Jaster, R., Liebe, S., & Emmrich, J. (2005) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520510023404 · Cited by 8 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Cellular senescence: from physiology to pathology
Muñoz-Espín, D., & Serrano, M. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3823 · Cited by 2,818 · see citing works
Cellular senescence in ageing: from mechanisms to therapeutic opportunities
Di Micco, R., Krizhanovsky, V., Baker, D., & d’Adda di Fagagna, F. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00314-w · Cited by 2,277 · see citing works
Senescent cells: an emerging target for diseases of ageing
Childs, B. G., Gluscevic, M., Baker, D. J., Laberge, R.-M., Marquess, D., Dananberg, J., & van Deursen, J. M. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.116 · Cited by 1,284 · see citing works
Bao, H., Cao, J., Chen, M., Min, C., Chen, W., Chen, X., Chen, Y., Chen, Y., Chen, Y., Chen, Z., et al. (2023) · Science China Life Sciences · doi:10.1007/s11427-023-2305-0 · Cited by 389 · see citing works
Pancreatic stellate cells: a starring role in normal and diseased pancreas
Apte, M. V., Pirola, R. C., & Wilson, J. S. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00344 · Cited by 321 · see citing works
Physiological and pathological consequences of cellular senescence
Burton, D. G. A., & Krizhanovsky, V. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1691-3 · Cited by 253 · see citing works
Cellular senescence: Immunosurveillance and future immunotherapy
Burton, D. G. A., & Stolzing, A. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.02.001 · Cited by 221 · see citing works
Immunosurveillance of senescent cells: the bright side of the senescence program
Sagiv, A., & Krizhanovsky, V. (2013) · Biogerontology · doi:10.1007/s10522-013-9473-0 · Cited by 208 · see citing works
Pancreatic stellate cell: Pandora's box for pancreatic disease biology
Bynigeri, R. R., Jakkampudi, A., Jangala, R., Subramanyam, C., Sasikala, M., Rao, G. V., Reddy, D. N., & Talukdar, R. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i3.382 · Cited by 179 · see citing works
The Senescence Markers p16INK4A, p14ARF/p19ARF, and p21 in Organ Development and Homeostasis
Wagner, K., & Wagner, N. (2022) · Cells · doi:10.3390/cells11121966 · Cited by 156 · see citing works
Senescent cells: Living or dying is a matter of NK cells
Antonangeli, F., Zingoni, A., Soriani, A., & Santoni, A. (2019) · Journal of Leukocyte Biology · doi:10.1002/jlb.mr0718-299r · Cited by 130 · see citing works
A Rising Star in Pancreatic Diseases: Pancreatic Stellate Cells
Xue, R., Jia, K., Wang, J., Yang, L., Wang, Y., Gao, L., & Hao, J. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00754 · Cited by 112 · see citing works
Targeting Senescent Cells in Fibrosis: Pathology, Paradox, and Practical Considerations
Schafer, M. J., Haak, A. J., Tschumperlin, D. J., & LeBrasseur, N. K. (2018) · Current Rheumatology Reports · doi:10.1007/s11926-018-0712-x · Cited by 103 · see citing works
Stellate Cells in Tissue Repair, Inflammation, and Cancer
Sherman, M. H. (2018) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100617-062855 · Cited by 102 · see citing works
Cellular senescence: from growth arrest to immunogenic conversion
Burton, D. G. A., & Faragher, R. (2015) · AGE · doi:10.1007/s11357-015-9764-2 · Cited by 95 · see citing works
Noncoding RNA control of cellular senescence
Abdelmohsen, K., & Gorospe, M. (2015) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1297 · Cited by 90 · see citing works
Pancreatic Cancer and Cellular Senescence: Tumor Microenvironment under the Spotlight
Cortesi, M., Zanoni, M., Pirini, F., Tumedei, M. M., Ravaioli, S., Rapposelli, I. G., Frassineti, G. L., & Bravaccini, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010254 · Cited by 60 · see citing works
Merkt, W., Zhou, Y., Han, H., & Lagares, D. (2021) · Wound Repair and Regeneration · doi:10.1111/wrr.12952 · Cited by 56 · see citing works
Cellular senescence: friend or foe to respiratory viral infections?
Kelley, W. J., Zemans, R. L., & Goldstein, D. R. (2020) · European Respiratory Journal · doi:10.1183/13993003.02708-2020 · Cited by 44 · see citing works
The role of cellular senescence in aging through the prism of Koch-like criteria
Yanai, H., & Fraifeld, V. E. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2017.10.004 · Cited by 45 · see citing works
Systemic inflammation contributes to impairment of quality of life in chronic pancreatitis
Robinson, S. M., Rasch, S., Beer, S., Valantienė, I., Mickevičius, A., Schlaipfer, E., Mann, J., Maisonneuve, P., Charnley, R., & Rosendahl, J. (2019) · Scientific Reports · doi:10.1038/s41598-019-43846-8 · Cited by 40 · see citing works
Grabliauskaite, K., Hehl, A. B., Seleznik, G. M., Saponara, E., Schlesinger, K., Zuellig, R. A., Dittmann, A., Bain, M., Reding, T., Sonda, S., et al. (2015) · The Journal of Pathology · doi:10.1002/path.4440 · Cited by 27 · see citing works
Arrested development and the great escape – The role of cellular senescence in pancreatic cancer
Moir, J. A. G., White, S. A., & Mann, J. (2014) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2014.10.018 · Cited by 25 · see citing works
Role of cellular senescence in hepatic wound healing and carcinogenesis
Ramakrishna, G., Anwar, T., Angara, R. K., Chatterjee, N., Kiran, S., & Singh, S. (2012) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2012.08.002 · Cited by 24 · see citing works
Bläuer, M., Sand, J. A., & Laukkarinen, J. (2015) · Pancreatology · doi:10.1016/j.pan.2015.05.044 · Cited by 21 · see citing works
Changes in Pancreatic Senescence Mediate Pancreatic Diseases
Li, K., Bian, J., Xiao, Y., Wang, D., Han, L., He, C., Gong, L., & Wang, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043513 · Cited by 20 · see citing works
The Role of Cellular Senescence in the Gastrointestinal Mucosa
Penfield, J. D., Anderson, M. A., Lutzke, L. L., & Wang, K. K. (2013) · Gut and Liver · doi:10.5009/gnl.2013.7.3.270 · Cited by 20 · see citing works
Chronic Infections: A Possible Scenario for Autophagy and Senescence Cross-Talk
Aguilera, M. O., Delgui, L. R., Romano, P. S., & Colombo, M. I. (2018) · Cells · doi:10.3390/cells7100162 · Cited by 20 · see citing works
The potential role of senescence in limiting fibrosis caused by aging
Meng, X., Wang, H., Song, X., Clifton, A. C., & Xiao, J. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29313 · Cited by 19 · see citing works
Retinoids in Stellate Cells: Development, Repair, and Regeneration
Carmona, R., Barrena, S., & Muñoz‐Chápuli, R. (2019) · Journal of Developmental Biology · doi:10.3390/jdb7020010 · Cited by 18 · see citing works
Targeting KRAS in pancreatic cancer: Emerging therapeutic strategies
Khan, S. U., Budamagunta, V., & Zhou, D. (2023) · Advances in cancer research · doi:10.1016/bs.acr.2023.02.004 · Cited by 18 · see citing works
The Dual Role of Senescence in Pancreatic Ductal Adenocarcinoma
Porciuncula, A., Hajdu, C. H., & David, G. (2016) · Advances in cancer research · doi:10.1016/bs.acr.2016.05.006 · Cited by 18 · see citing works
Mettl14-driven senescence-associated secretory phenotype facilitates somatic cell reprogramming
Xi, C., Sun, J., Xu, X., Wu, Y., Kou, X., Zhao, Y., Shen, J., Dong, Y., Chen, K., Su, Z., et al. (2022) · Stem Cell Reports · doi:10.1016/j.stemcr.2022.06.012 · Cited by 17 · see citing works
Senescence, Aging and Disease Throughout the Gastrointestinal System
Ferreira-González, S., Matsumoto, T., Hara, E., & Forbes, S. J. (2025) · Gastroenterology · doi:10.1053/j.gastro.2025.06.010 · Cited by 16 · see citing works
Cellular Senescence and Ageing
Reed, R., & Miwa, S. (2023) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-21410-3_7 · Cited by 16 · see citing works
Senescence program and its reprogramming in pancreatic premalignancy
Yang, K., Li, X., & Xie, K. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06040-3 · Cited by 16 · see citing works
Low-dose tributyltin triggers human chondrocyte senescence and mouse articular cartilage aging
Chung, Y.-P., Weng, T., Chan, D., Yang, R., & Liu, S. (2022) · Archives of Toxicology · doi:10.1007/s00204-022-03407-x · Cited by 14 · see citing works
Sheng, L., Han, C., Nie, C., Xu, T., Zhang, K., Li, X.-J., Xie, X., Lin, R., & Ding, Z. (2021) · Medicine · doi:10.1097/md.0000000000025753 · Cited by 14 · see citing works
Zhang, K., Chen, C., Liu, Y., Chen, H., & Liu, J. (2014) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12328 · Cited by 14 · see citing works
Mitochondria in cell senescence: A Friend or Foe?
Chen, Q., Young, L. H., & Barsotti, R. (2023) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2023.02.019 · Cited by 13 · see citing works
Flip a coin: cell senescence at the maternal–fetal interface
Gong, G.-S., Muyayalo, K. P., Zhang, Y., Lin, X., & Liao, A. (2023) · Biology of Reproduction · doi:10.1093/biolre/ioad071 · Cited by 13 · see citing works
YAP activates pancreatic stellate cells and enhances pancreatic fibrosis
Spanehl, L., Revskij, D., Bannert, K., Ehlers, L., & Jaster, R. (2022) · Hepatobiliary & pancreatic diseases international · doi:10.1016/j.hbpd.2022.06.004 · Cited by 13 · see citing works
Self-citationImmune Aging and How It Works for Inflammation and Fibrosis
Nishiura, H., Imasaka, M., Yamanegi, K., Fujimoto, J., & Ohmuraya, M. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2021.795508 · Cited by 9 · see citing works
Ling, L., Guo, Q., Cheng, Y., Gui, Y., Li, W., Zhao, Y., Xu, Z., Luo, Y., Wu, G., Wang, J., et al. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.06.033 · Cited by 9 · see citing works
Cdkn1a is a key mediator of rat pancreatic stellate cell senescence
Fitzner, B., Lange, A., Müller, S., & Jaster, R. (2013) · Pancreatology · doi:10.1016/j.pan.2013.03.009 · Cited by 8 · see citing works
Self-citationAlterations in exocrine pancreatic function after acute pancreatitis
Bejjani, J., Ramsey, M. L., Lee, P. J., Phillips, A. E., Singh, V. K., Yadav, D. K., Papachristou, G. I., & Hart, P. A. (2024) · Pancreatology · doi:10.1016/j.pan.2024.03.003 · Cited by 6 · see citing works
Targeting senescent cell clearance: An approach to delay aging and age-associated disorders
Qiu, Z., Jia, J., Zou, H., Ao, Y., Liu, B., & Wang, Z. (2021) · Translational Medicine of Aging · doi:10.1016/j.tma.2020.12.001 · Cited by 6 · see citing works
Apte, M. V., Pirola, R. C., & Wilson, J. S. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800134-9.00016-6 · Cited by 6 · see citing works
Chandrasegaran, S., Sluka, J. P., & Shanley, D. P. (2025) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1012298 · Cited by 8 · see citing works
Lütt, F., Ehlers, L., Nizze, H., & Jaster, R. (2019) · Hepatobiliary & pancreatic diseases international · doi:10.1016/j.hbpd.2019.10.007 · Cited by 5 · see citing works
Self-citationBloemberg, D., & Quadrilatero, J. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.30079 · Cited by 5 · see citing works
Uncoupling protein 2 deficiency reduces proliferative capacity of murine pancreatic stellate cells
Müller, S., Klingbeil, S. M., Sandica, A. M., & Jaster, R. (2016) · Hepatobiliary & pancreatic diseases international · doi:10.1016/s1499-3872(16)60154-6 · Cited by 5 · see citing works
Self-citation[The effect of deep branches of cervical nerve on motorial function of trapezius muscle].
Wang, F., Wen, Y., & Li, L. (2003) · PubMed · Cited by 4 · see citing works
Glover, M., Maher, J. F., & Davies, D. M. (2026) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2026.2622794 · Cited by 2 · see citing works
Borufka, L., Volmer, E., Müller, S., Engelmann, R., Nizze, H., Ibrahim, S. M., & Jaster, R. (2016) · Oncotarget · doi:10.18632/oncotarget.10265 · Cited by 2 · see citing works
Self-citationSarhan, N. R., Nashar, E. M. E., Hamza, E., El-Beah, S. M., Alghamdi, M. A., Al-Khater, K. M., Aldahhan, R. A., & Abul-Ela, E. S. A.-A. (2023) · Tissue and Cell · doi:10.1016/j.tice.2023.102192 · Cited by 1 · see citing works
Functional Features of the Pancreas during Chronic Pancreatitis
Fedorovych, S. B., Babiy, A. M., Tatarchuk, О. М., Makarchuk, V. A., & Kudryavtseva, V. E. (2016) · GASTROENTEROLOGY · doi:10.22141/2308-2097.3.61.2016.79157 · Cited by 1 · see citing works
Examining Autophagy and Mitophagy as Inducible Mechanisms of Cellular Remodelling
Bloemberg, D. (2017) · UWSpace (University of Waterloo) · Cited by 1 · see citing works
Apte, M. V., Pirola, R. C., & Wilson, J. S. (2018) · doi:10.1002/9781119188421.ch10 · Cited by 1 · see citing works
Role of stellate cells in the morphogenesis of chronic pancreatitis
Mozhejko, L. A. (2019) · Proceedings of the National Academy of Sciences of Belarus Medical series · doi:10.29235/1814-6023-2018-15-4-455-464
Senotherapeutics: Experimental therapy of cellular senescence
Justice, J. N., Niedernhofer, L. J., & Orr, M. E. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-815962-0.00012-3
Cellular Senescence Limits the Extent of Fibrosis Following Liver Damage
Krizhanovsky, V. (2013) · Springer eBooks · doi:10.1007/978-94-007-5958-9_25
Analysis of senescence markers in rodent pancreatic stellate cells
Müller, S. (2013) · doi:10.3998/panc.2013.3
Self-citationRôle de l’immunosurveillance des cellules sénescentes dans le cancer et le vieillissement
Iltis, C. (2020) · theses.fr (ABES) · doi:10.70675/9a339b58z5fecz427dz8de4z8ce0bd748478
- Authors
- Fitzner, B., Müller, S., Walther, M., Fischer, M., Engelmann, R., Müller‐Hilke, B., Pützer, B. M., Kreutzer, M., Nizze, H., & Jaster, R.
- Affiliations
- Universitätsmedizin Rostock (DE)
- University of Rostock (DE)
- Corresponding author
- Jaster, Robert
- ORCID
- Venue
- Journal of Cellular and Molecular Medicine
- Publisher
- Wiley
- Published
- 2012-10-29
- Volume
- 16
- Issue
- 11
- Pages
- 2620-2630
- ISSN
- 1582-1838 (ISSN-L)
- 1582-4934
- PMC
- PMC4118230
- OpenAlex
- W2015665286
- Cited by
- 66
- References
- 29
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 8 · 2022: 5 · 2021: 6 · 2020: 4 · 2019: 7 · 2018: 7 · 2017: 4 · 2016: 4 · 2015: 4 · 2014: 5 · 2013: 4 · 2012: 2
- FWCI
- 5.22
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Journal of Cellular and Molecular Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Keywords
- cellular senescence, pancreatic stellate cells, chronic pancreatitis, pancreatic fibrosis, senescence-associated β-galactosidase, CDKN1A/p21, MDM2, interleukin-6, doxorubicin, hydrogen peroxide, staurosporine, dibutyltin dichloride, inflammation, tissue repair, lymphocytes
- MeSH terms
- Animals, beta-Galactosidase, Cells, Cultured, Doxorubicin, Fibrosis, Hydrogen Peroxide, Killer Cells, Natural, Male, Organotin Compounds, Pancreas, Rats, Inbred Lew, Spleen, Biomarkers, Gene Expression, Cellular Senescence, Coculture Techniques, Staurosporine, Pancreatitis, Chronic, Rats, Pancreatic Stellate Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
