The conus demyelination syndrome in multiple sclerosis
Abstract
Bowel, bladder and sexual dysfunction are common in multiple sclerosis and are generally attributed to the widespread nature of the involvement of the neuroaxis by the demyelinating plaques. Recently we encountered a specific subset of patients within this group who had characteristic clinical complaints of hesitancy, straining and incomplete voiding, perineal hypesthesia on examination, areflexia by cystometry and colonometry and electrophysiological parameters suggesting involvement of the conus medullaris. This heretofore postulated but undocumented mechanism of neurovisceral dysfunction in multiple sclerosis is detailed and discussed in 2 patients in this report.
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These complications may occur due to demyelinating lesions of the conus medullaris or more proximal lesions.
“These complications may be occurred due to demyelinating lesions of the conus medullaris or more proximal lesions [29].”
Cites
Bladder Dysfunction in Multiple Sclerosis
Miller, H. A., Simpson, C. A., & Yeates, W. K. (1965) · BMJ · doi:10.1136/bmj.1.5445.1265 · Cited by 204 · see citing works
THE CENTRIFUGAL PATHWAY FOR MICTURITION WITHIN THE SPINAL CORD
Nathan, P. W., & SMITH, M. C. (1958) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.21.3.177 · Cited by 121 · cited 1× · see citing works
“The investigations of Nathan & Smith (11, 12) further suggest that the pathways for sexual”
BackgroundTHE CENTRIPETAL PATHWAY FROM THE BLADDER AND URETHRA WITHIN THE SPINAL CORD
Nathan, P. W., & SMITH, M. C. (1951) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.14.4.262 · Cited by 112 · cited 1× · see citing works
“The investigations of Nathan & Smith (11, 12) further suggest that the pathways for sexual”
BackgroundTOPOGRAPHIC DISTRIBUTION OF PLAQUES IN THE SPINAL CORD IN MULTIPLE SCLEROSIS
Fog, T. (1950) · Archives of Neurology And Psychiatry · doi:10.1001/archneurpsyc.1950.02310210028003 · Cited by 106 · cited 1× · see citing works
“The topographic nature of the spinal cord involvement secondary to multiple sclerosis is defined by Fog (14).”
BackgroundAbnormalities of Detrusor and Sphincter Function in Multiple Sclerosis
Andersen, J. T., & Bradley, W. E. (1976) · British Journal of Urology · doi:10.1111/j.1464-410x.1976.tb10198.x · Cited by 103 · cited 1× · see citing works
“The incidence and nature of the bladder disturbances associated with multiple sclerosis is well documented (1, 2, 3).”
BackgroundSelf-citationCystometric and sphincter abnormalities in multiple sclerosis
Bradley, W. E., Logothetis, J. L., & Timm, G. W. (1973) · Neurology · doi:10.1212/wnl.23.10.1131 · Cited by 88 · cited 1× · see citing works
“The incidence and nature of the bladder disturbances associated with multiple sclerosis is well documented (1, 2, 3).”
BackgroundSelf-citationNEUROGENIC DISTURBANCES OF THE COLON AND THEIR INVESTIGATION BY THE COLONMETROGRAM
White, J. C., Verlot, M. G., & Ehrentheil, O. F. (1940) · Annals of Surgery · doi:10.1097/00000658-194012000-00004 · Cited by 84 · see citing works
Sexual problems in patients suffering from multiple sclerosis
Hg, L., Valtonen, E. J., & Wikstrom, J. (1976) · Journal of Chronic Diseases · doi:10.1016/0021-9681(76)90021-7 · Cited by 79 · see citing works
Wasserman, M. D., Pollak, C. P., Spielman, A. J., & Weitzman, E. D. (1980) · Psychosomatic Medicine · doi:10.1097/00006842-198011000-00006 · Cited by 75 · cited 1× · see citing works
“The intactness of the suprasegmental influence can be grossly measured by the nocturnal penile tumescence (NPT) study, the reliability of which has recently been brought under question (13).”
BackgroundThe central control of the lumbar sympathetic pathway to the large intestine of the cat.
de Groat, W. C., & Krier, J. (1979) · The Journal of Physiology · doi:10.1113/jphysiol.1979.sp012746 · Cited by 68 · cited 1× · see citing works
“Animal studies dispute the r61e of suprasegmental influences in the modulation of defecation reflex activity (9).”
BackgroundSpinal cord organization of micturition reflex afferents
Bradley, W. E., & Teague, C. T. (1968) · Experimental Neurology · doi:10.1016/0014-4886(68)90145-3 · Cited by 54 · cited 1× · see citing works
“the sacral connections involved in the smooth coordination of micturition (7).”
BackgroundSelf-citationNeuro-urological investigation in urinary bladder dysfunction
Andersen, J., & Bradley, W. E. (1977) · International Urology and Nephrology · doi:10.1007/bf02082015 · Cited by 6 · see citing works
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Research works printed but not linked: 2
- Scott, 1949, Colonometric studies of the effects of section of the parasympathetic nerves of the colon, Bull Johns Hopkins Hosp, 85, 310
- Bors, 1960, Neurological disturbances of sexual function with reference to 529 patients with spinal cord injury, Urol Survey, 10, 191
Cited by
Sorted by citations
Urinary symptoms and the neurological features of bladder dysfunction in multiple sclerosis.
Betts, C. D., D'Mellow, M. T., & Fowler, C. J. (1993) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.56.3.245 · Cited by 274 · see citing works
Pathophysiology and management of bowel dysfunction in multiple sclerosis
Wiesel, P. H., Norton, C., Glickman, S., & Kamm, M. A. (2001) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200104000-00025 · Cited by 121 · see citing works
YANG, C. C., Bowen, J., Kraft, G. H., et al. (2000) · The Journal of Urology · doi:10.1016/s0022-5347(05)66941-8 · Cited by 66 · see citing works
Vodušek, D. B. (1996) · Urologic Clinics of North America · doi:10.1016/s0094-0143(05)70323-2 · Cited by 60 · see citing works
Electrophysiology of motor pathways for sphincter control in multiple sclerosis.
Mathers, S., Ingram, D. A., & Swash, M. (1990) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.53.11.955 · Cited by 55 · see citing works
Infarction of the conus medullaris
Anderson, N. E., & Willoughby, E. W. (1987) · Annals of Neurology · doi:10.1002/ana.410210510 · Cited by 46 · see citing works
Parity as a Factor in Incontinence in Multiple Sclerosis
Swash, M., Snooks, S. J., & Chalmers, D. H. K. (1987) · Archives of Neurology · doi:10.1001/archneur.1987.00520170034018 · Cited by 45 · see citing works
Sarıca, Y., & Karacan, I. (1987) · The Journal of Urology · doi:10.1016/s0022-5347(17)42987-9 · Cited by 37 · see citing works
Clinical uro‐neurophysiological investigation in multiple sclerosis
Rodi, Z., Vodušek, D. B., & Denišlič, M. (1996) · European Journal of Neurology · doi:10.1111/j.1468-1331.1996.tb00275.x · Cited by 23 · see citing works
Intravascular Lymphoma with Conus Medullaris Syndrome Followed by Encephalopathy
Savard, M., Verreault, S., Gould, P. V., et al. (2008) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100008982 · Cited by 14 · see citing works
Foshati, S., Poursadeghfard, M., Heidari, Z., & Amani, R. (2023) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-023-04227-x · Cited by 11 · see citing works
“These complications may be occurred due to demyelinating lesions of the conus medullaris or more proximal lesions [29].”
BackgroundReport of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology (1995) · Neurology · doi:10.1212/wnl.45.12.2287 · Cited by 11 · see citing works
Pathophysiology of male sexual dysfunction in multiple sclerosis
Betts, C. D. (1996) · Sexuality and Disability · doi:10.1007/bf02590617 · Cited by 6 · see citing works
“In MS, the urodynamic finding of bladder hyperreflexia is thought to result from suprasacral spinal cord disease (18,27) whereas conus lesions would be expected to cause detrusor areflexia (13, 52 ).”
BackgroundHypersexual sensations and behavior in a multiple sclerosis exacerbation: a case report
Yang, C. C., Severson, B., & Bowen, J. D. (2004) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3901201 · Cited by 4 · see citing works
Female sexual function in neurologic disease
Yang, C. C. (2000) · The Journal of Sex Research · doi:10.1080/00224490009552041 · Cited by 4 · see citing works
Place of perineal electrophysiologic testing in multiple sclerosis patients
Podnar, S., & Vodušek, D. B. (2014) · Annals of Physical and Rehabilitation Medicine · doi:10.1016/j.rehab.2014.05.005 · Cited by 3 · see citing works
Multiple sclerosis and other non-compressive myelopathies
Dalton, C. M., Preziosi, G., Khan, S., et al. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511762611.016 · Cited by 2 · see citing works
Fowler, C. J., Panicker, J. N., & Emmanuel, A. V. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511762611.013 · Cited by 2 · see citing works
Constipation Treatment in Neurological Disorders
Gallelli, L., Pirritano, D., Palleria, C., & Sarro, D. (2012) · InTech eBooks · doi:10.5772/29813 · Cited by 1 · see citing works
“Some authors associated large bowel dysfunction to demyelinating lesions of the conus medullaris, even if the role of more proximal lesions cannot be ruled out (Taylor et al., 1984).”
BackgroundConus Medullaris Dysfunction: Central and Peripheral Pathology
Ruscalleda, J., Zamora, A., Rovira, À., et al. (2001) · Rivista di Neuroradiologia · doi:10.1177/197140090101400207
Bharucha, A. E., & Camilleri, M. (2005) · Elsevier eBooks · doi:10.1016/b978-0-7216-9491-7.50124-1
Williams, N. S. (1991) · Springer eBooks · doi:10.1007/978-1-4471-1822-0_8
Mathers, S., & Swash, M. (1988) · International Disability Studies · doi:10.3109/09638288809164070
- Authors
- Taylor, M. C., Bradley, W. E., Bhatia, N., Glick, M., & Haldeman, S.
- Affiliations
- University of California, Irvine (US)
- Corresponding author
- Taylor, Mary C.
- Venue
- Acta Neurologica Scandinavica
- Publisher
- Hindawi Limited
- Published
- 1984-02
- Volume
- 69
- Issue
- 2
- Pages
- 80-89
- ISSN
- 0001-6314 (ISSN-L)
- 1600-0404
- OpenAlex
- W2095202900
- Semantic Scholar
- 4c2358c9e143afbf5de1dbdb54e2a56489bf220f
- Cited by
- 23
- References
- 12
- Citations by year
- 2023: 1 · 2014: 1 · 2012: 1
- FWCI
- 1.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Neurologica Scandinavica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Urology › Urinary Bladder and Prostate Research
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Keywords
- multiple sclerosis, neurogenic bladder, neurogenic bowel dysfunction, sexual dysfunction, cystometry, conus medullaris
- MeSH terms
- Adult, Urinary Bladder, Demyelinating Diseases, Female, Humans, Intestines, Male, Middle Aged, Multiple Sclerosis, Reflex, Abnormal, Sexual Dysfunction, Physiological, Spinal Cord Diseases
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