Serum and CSF immunological findings in ALS
Abstract
Serum and CSF immunological findings were analysed in 37 patients with amyotrophic lateral sclerosis (ALS). ALS patients had significantly higher mean values of serum IgG and complement component C4 and significantly lower mean value of total haemolytic titre of complement (THC) compared with normal controls. Incidence of immune complexes (ICs) was significantly higher in sera of ALS patients than in normal controls. There was no significant difference regarding mean serum levels of IgM, IgA, and complement components C3 and Factor B between patients and controls. The blood-brain barrier (BBB) damage was found in 46% of patients. Intrathecal IgG synthesis was detected in six patients (16%). These results support the hypothesis of immune system involvement in ALS.
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Increased Qalb values were found in 40% of all studied amyotrophic lateral sclerosis cases (55/138 from 4 independent studies).
“increased Qalb values were found in 40% of all studied ALS cases (i.e., 55/138 from 4 independent studies) (23, 79, 407, 525)”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [23]
Cites
Deposits of IgG and C3 in the spinal cord and motor cortex of ALS patients
Donnenfeld, H., Kascsak, R. J., & Bartfeld, H. (1984) · Journal of Neuroimmunology · doi:10.1016/0165-5728(84)90042-0 · Cited by 119 · see citing works
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Blood-Brain Barrier: From Physiology to Disease and Back
Sweeney, M. D., Zhao, Z., Montagne, A., Nelson, A. R., & Zlokovic, B. V. (2019) · Physiological Reviews · doi:10.1152/physrev.00050.2017 · Cited by 2,294 · see citing works
The role of soluble intercellular adhesion molecules in neurodegenerative disorders
Rentzos, M., Michalopoulou, M., Nikolaou, C., Cambouri, C., Rombos, A., Dimitrakopoulos, A., & Vassilopoulos, D. (2005) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2004.11.001 · Cited by 45 · see citing works
- Authors
- Apostolski, S., Nikolić, J., Bugarski-Prokopljević, C., Miletić, V., Pavlović, S., & Filipović, S.
- Affiliations
- University Clinical Centre (PL)
- Corresponding author
- Apostolski, S.
- ORCID
- Filipović, S.
- Venue
- Acta Neurologica Scandinavica
- Publisher
- Hindawi Limited
- Published
- 1991-02
- Volume
- 83
- Issue
- 2
- Pages
- 96-98
- ISSN
- 0001-6314 (ISSN-L)
- 1600-0404
- OpenAlex
- W2041110092
- Cited by
- 114
- References
- 1
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 5 · 2022: 5 · 2021: 9 · 2020: 8 · 2019: 6 · 2018: 6 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 5 · 2013: 4 · 2012: 7
- FWCI
- 3.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Neurologica Scandinavica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Keywords
- amyotrophic lateral sclerosis, cerebrospinal fluid, immune complexes, serum IgG, complement C4, blood-brain barrier disruption, intrathecal IgG synthesis, immune system involvement
- MeSH terms
- Adult, Aged, Amyotrophic Lateral Sclerosis, Antigen-Antibody Complex, Blood-Brain Barrier, Complement C4, Female, Humans, Immunoglobulin G, Immunoglobulins, Male, Middle Aged, Serum Albumin
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