Cited by 119Amyotrophic Lateral Sclerosis ResearchPeripheral Neuropathies and DisordersMultiple Sclerosis Research Studies

Deposits of IgG and C3 in the spinal cord and motor cortex of ALS patients

Donnenfeld, H., Kascsak, R.J., Bartfeld, H.·1984·Journal of Neuroimmunology

Abstract

Deposits of IgG and complement were demonstrated by direct immunofluorescent techniques with sections of motor cortex and spinal cord from amyotrophic lateral sclerosis (ALS) patients. Six of 16 ALS patients showed deposits within the spinal cord while 5 of 13 showed similar deposits within the motor cortex. The specificity of this staining was shown by blocking experiments and the use of conjugated F(ab')2. Similar deposits were found in the CNS in disease states associated with possible immune or infectious etiologies and were not found in the CNS of normal controls.

Integrity signals

Registry

Crossref · 10.1016/0165-5728(84)90042-0

Cites

8 of 8 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Blood-brain barrier and blood-spinal cord barrier are damaged in a subset of amyotrophic lateral sclerosis patients, with plasma-derived IgG accumulation in spinal cord and motor cortex in 40-90% of cases and peripheral blood cell accumulation in 70-100% of cases.

    “These findings support earlier observations showing that the BBB and BSCB are damaged in a subset of ALS patients as demonstrated by accumulation of plasma-derived IgG in the spinal cord and motor cortex in 40% (154) to 90% (163) of studied cases, and accumulation of peripheral blood cells in 70% (164) to 100% (599) of studied cases.”

    From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [154]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Donnenfeld, H., Kascsak, R. J., & Bartfeld, H.
Affiliations
Saint Vincent's Catholic Medical Center (US)
Corresponding author
Donnenfeld, H.
Venue
Journal of Neuroimmunology
Publisher
Elsevier BV
Published
1984-02
Volume
6
Issue
1
Pages
51-57
ISSN
0165-5728 (ISSN-L)
OpenAlex
W2012006815
Cited by
119
References
8
Citations by year
2026: 2 · 2025: 6 · 2024: 4 · 2023: 4 · 2022: 6 · 2021: 15 · 2020: 7 · 2019: 6 · 2018: 4 · 2017: 6 · 2016: 5 · 2015: 4 · 2014: 2 · 2013: 4 · 2012: 8
FWCI
2.22
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neuroimmunology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
  • Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
Keywords
amyotrophic lateral sclerosis, IgG deposits, complement C3, spinal cord, motor cortex, neuroinflammation, immune deposits, central nervous system, direct immunofluorescence
MeSH terms
Aged, Amyotrophic Lateral Sclerosis, Antibodies, Antigen-Antibody Complex, Binding, Competitive, Complement C3, Female, Fluorescent Antibody Technique, Humans, Immunoglobulin G, Male, Middle Aged, Motor Cortex, Spinal Cord

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review