Deposits of IgG and C3 in the spinal cord and motor cortex of ALS patients
Abstract
Deposits of IgG and complement were demonstrated by direct immunofluorescent techniques with sections of motor cortex and spinal cord from amyotrophic lateral sclerosis (ALS) patients. Six of 16 ALS patients showed deposits within the spinal cord while 5 of 13 showed similar deposits within the motor cortex. The specificity of this staining was shown by blocking experiments and the use of conjugated F(ab')2. Similar deposits were found in the CNS in disease states associated with possible immune or infectious etiologies and were not found in the CNS of normal controls.
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Blood-brain barrier and blood-spinal cord barrier are damaged in a subset of amyotrophic lateral sclerosis patients, with plasma-derived IgG accumulation in spinal cord and motor cortex in 40-90% of cases and peripheral blood cell accumulation in 70-100% of cases.
“These findings support earlier observations showing that the BBB and BSCB are damaged in a subset of ALS patients as demonstrated by accumulation of plasma-derived IgG in the spinal cord and motor cortex in 40% (154) to 90% (163) of studied cases, and accumulation of peripheral blood cells in 70% (164) to 100% (599) of studied cases.”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [154]
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- Authors
- Donnenfeld, H., Kascsak, R. J., & Bartfeld, H.
- Affiliations
- Saint Vincent's Catholic Medical Center (US)
- Corresponding author
- Donnenfeld, H.
- Venue
- Journal of Neuroimmunology
- Publisher
- Elsevier BV
- Published
- 1984-02
- Volume
- 6
- Issue
- 1
- Pages
- 51-57
- ISSN
- 0165-5728 (ISSN-L)
- OpenAlex
- W2012006815
- Cited by
- 119
- References
- 8
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 4 · 2023: 4 · 2022: 6 · 2021: 15 · 2020: 7 · 2019: 6 · 2018: 4 · 2017: 6 · 2016: 5 · 2015: 4 · 2014: 2 · 2013: 4 · 2012: 8
- FWCI
- 2.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroimmunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Keywords
- amyotrophic lateral sclerosis, IgG deposits, complement C3, spinal cord, motor cortex, neuroinflammation, immune deposits, central nervous system, direct immunofluorescence
- MeSH terms
- Aged, Amyotrophic Lateral Sclerosis, Antibodies, Antigen-Antibody Complex, Binding, Competitive, Complement C3, Female, Fluorescent Antibody Technique, Humans, Immunoglobulin G, Male, Middle Aged, Motor Cortex, Spinal Cord
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