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Cited by 161

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

CSF biomarkers in the evaluation of idiopathic normal pressure hydrocephalus

Open access
Ågren-Wilsson, A., Lekman, A., Sjöberg, W., Rosengren, L., Blennow, K., Bergenheim, A. T., Malm, J.·2007·Acta Neurologica Scandinavica

Abstract

BACKGROUND - To evaluate cerebrospinal fluid (CSF) markers for neuronal degeneration and demyelination in idiopathic normal pressure hydrocephalus (INPH), subcortical arteriosclerotic encephalopathy (SAE), and neurologically healthy subjects. METHODS - Lumbar CSF concentrations of sulfatide, neurofilament protein light (NFL), total-tau (T-tau), hyperphosphorylated tau (P-tau), and beta-amyloid(1-42) (Abeta42) were analyzed in 62 INPH patients, 26 SAE patients, and 23 neurologically healthy controls. In INPH patients, samples before and after shunt surgery were analysed. RESULTS - The CSF concentration of NFL was elevated in INPH and SAE compared with the controls, and levels of T-tau, P-tau, and Abeta42 were lower in INPH compared with SAE and controls. No difference was seen for sulfatide. All markers except Abeta42 were significantly elevated after shunt surgery. CONCLUSIONS - The most striking finding was the power of the combined pattern of NFL, P-tau, and Abeta42 in distinguishing between the clinical diagnoses of INPH, SAE, and neurologically healthy elderly.

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Metadata

Authors
Ågren-Wilsson, A., Lekman, A., Sjöberg, W., Rosengren, L., Blennow, K., Bergenheim, A. T., & Malm, J.
Venue
Acta Neurologica Scandinavica
Published
2007-11
Volume
116
Issue
5
Pages
333-339
ISSN
  • 0001-6314 (ISSN-L)
  • 1600-0404
OpenAlex
W2003469292
Cited by
161
References
5
FWCI
1.81
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: CSF biomarkers in the evaluation of idiopathic normal pressure hydrocephalus. https://app.cochat.ai/papers/10.1111/j.1600-0404.2007.00890.x
The paper
Ågren-Wilsson, A., Lekman, A., Sjöberg, W., Rosengren, L., Blennow, K., Bergenheim, A. T., & Malm, J. (2007). CSF biomarkers in the evaluation of idiopathic normal pressure hydrocephalus. Acta Neurologica Scandinavica. https://doi.org/10.1111/j.1600-0404.2007.00890.x

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