Cited by 151Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsCerebrospinal fluid and hydrocephalus

CSF biomarkers for mild cognitive impairment

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Blennow, K.·2004·Journal of Internal Medicine

Abstract

Abstract.: A correct clinical diagnosis of Alzheimer's disease (AD) early in the course of the disease is of importance to initiate symptomatic treatment with acetylcholine esterase inhibitors, and will be even more important when disease‐arresting drugs, such as β‐sheet breakers or γ‐secretase inhibitors, will reach the clinic. However, there is no clinical method to determine if a patient with mild cognitive impairment (MCI) has incipient AD, i.e. will progress to AD with dementia, or have a benign form of MCI without progression. Thus, there is a great clinical need for diagnostic biomarkers to identify incipient AD in MCI cases. Three cerebrospinal fluid (CSF) biomarkers; total‐tau (T‐τ), phospho‐tau (P‐τ) and the 42 amino acid form of β‐amyloid (A β 42) have been evaluated in numerous scientific papers. These CSF markers have high sensitivity to differentiate early and incipient AD from normal ageing, depression, alcohol dementia and Parkinson's disease, but lower specificity against other dementias, such as frontotemporal and Lewy body dementia. However, if the CSF biomarkers are used in the right clinical context, i.e. together with the cumulative information from the clinical examination, standard laboratory tests and brain‐imaging techniques [single photon emission tomography (SPECT) and magnetic resonance tomography (MRT) scans], they may have a role in the clinical evaluation of MCI cases.

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Crossref · 10.1111/j.1365-2796.2004.01368.x

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  • CSF measures of T-tau and Aβ1-42 levels are individually sensitive but have lower specificity for AD against other dementia disorders.

    “It has been found that the CSF measures of total tau (T-tau) and amyloid beta (Aβ1-42) levels are individually sensitive though but with lower specificity for AD against other dementia disorders (Blennow, 2004).”

    From T1rho MRI and CSF biomarkers in diagnosis of Alzheimer's disease (2015) · cites this paper as Blennow, 2004

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Research works printed but not linked: 3

  1. Bue ´e L, Bussiere T, Buee-Scherrer V, Delacourte A, Hof PR. Tau protein isoforms, phosphorylation and role in neurodegenerative disorders. Brain Res Brain Res Rev 2000; 33: 95-130.
  2. Hesse C, Rosengren L, Andreasen N et al. Transient increase in CSF total tau but not phospho-tau after acute stroke. Neurosci Lett 2001; 297: 187-90.
  3. Arai H, Nakagawa T, Kosaka Y et al. Elevated cerebrospinal fluid tau protein level as a predictor of dementia in memory- impaired patients. Alzheimer's Res 1997; 3: 211-3.

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Authors
Blennow, K.
Affiliations
University of Gothenburg (SE)
Corresponding author
Blennow, K.
Venue
Journal of Internal Medicine
Publisher
Wiley
Published
2004-08-20
Volume
256
Issue
3
Pages
224-234
ISSN
  • 0954-6820 (ISSN-L)
  • 1365-2796
OpenAlex
W2094761283
Cited by
151
References
102
Citations by year
2025: 3 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 3 · 2018: 7 · 2017: 2 · 2016: 9 · 2015: 13 · 2014: 7 · 2013: 6 · 2012: 7
FWCI
2.02
Type
journal article
Language
en
Open access
Locations
  • Journal of Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
Keywords
cerebrospinal fluid biomarkers, mild cognitive impairment, Alzheimer's disease, early diagnosis, total tau, phosphorylated tau, amyloid-beta 42, diagnostic accuracy, dementia progression, differential diagnosis of dementia, neuroimaging
MeSH terms
Aged, Alzheimer Disease, Cognition Disorders, Humans, Biomarkers, Amyloid beta-Peptides, tau Proteins, Disease Progression

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