The DOI matches its Crossref record; 35 of the 37 references it cites were found in a registry or an index.
A typological model of schizophrenia based on age at onset, sex and familial morbidity
Abstract
We investigated the age at onset distributions of schizophrenia in men and women and the relationship of age at onset and sex to the familial rates of schizophrenia and manic‐depression in data from a Swedish family study of 270 schizophrenic probands. On the logarithmic scale, the age at onset distribution of schizophrenia in both male and female relatives was bimodal, suggesting that broadly defined schizophrenia may be a mixture of 2 (probably related) disorders. The risk of schizophrenia in relatives decreased as a function of the age at onset of the proband, irrespective of the sex of the proband or relative. In contrast, the risk of manic‐depression was significantly higher in relatives of female probands with an age at onset in the twenties than in relatives of female probands with earlier or later onset, or in relatives of male probands. This suggests a third disorder related to affective psychosis, with an intermediate age at onset and female preponderance.
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“Second, the theory must account for why the symptoms of schizophrenia so commonly first present in late adolescence and early adulthood, with the majority of cases occurring between the ages of 16 and 30 years.5”
From Schizophrenia, myelination, and delayed corollary discharges: a hypothesis (2012) · cites this paper as [5]
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College Students: Mental Health Problems and Treatment Considerations
Pedrelli, P., Nyer, M., Yeung, A., Zulauf, C., & Wilens, T. (2015) · Academic Psychiatry · doi:10.1007/s40596-014-0205-9 · Cited by 1,325
“[27] studied 270 schizophrenic probands in an older Swedish study and found that for both males and females there was a rapid increase in the onset of schizophrenia in late teens and early twenties followed by a lower risk of onset in the late twenties.”
BackgroundOlfson, M., Blanco, C., Liu, S.-M., Wang, S., & Correll, C. U. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2012.647 · Cited by 355
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Metadata
- Authors
- Sham, P. C., MacLean, C. J., & Kendler, K. S.
- Affiliations
- Virginia Commonwealth University (US)
- Corresponding author
- Sham, P.C.
- Venue
- Acta Psychiatrica Scandinavica
- Publisher
- Wiley
- Published
- 1994-02
- Volume
- 89
- Issue
- 2
- Pages
- 135-141
- ISSN
- 0001-690X (ISSN-L)
- 1600-0447
- OpenAlex
- W2139391643
- Cited by
- 122
- References
- 37
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 2 · 2022: 5 · 2021: 7 · 2020: 6 · 2019: 12 · 2018: 8 · 2017: 15 · 2016: 6 · 2015: 6 · 2014: 1 · 2013: 10 · 2012: 5
- FWCI
- 1.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Psychiatrica Scandinavica (publishedVersion)
- PubMed (publishedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Funders
- John D. and Catherine T. MacArthur Foundation
- Wellcome Trust
- National Institute of Mental Health (R01MH041953, NIMH MH41953)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- schizophrenia, age of onset, sex differences, familial risk, bipolar disorder, affective psychosis, bimodal age distribution, probands, family studies, schizophrenia subtypes
- MeSH terms
- Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Bipolar Disorder, Child, Female, Humans, Male, Middle Aged, Models, Genetic, Phenotype, Risk Factors, Schizophrenia, Schizophrenic Psychology, Sex Factors, Sweden
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