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The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.

Guided Bone Regeneration: biological principle and therapeutic applications

Retzepi, M., Donos, N.·2010·Clinical Oral Implants Research

Abstract

The Guided Bone Regeneration (GBR) treatment concept advocates that regeneration of osseous defects is predictably attainable via the application of occlusive membranes, which mechanically exclude non‐osteogenic cell populations from the surrounding soft tissues, thereby allowing osteogenic cell populations originating from the parent bone to inhabit the osseous wound. The present review discusses the evolution of the GBR biological rationale and therapeutic concept over the last two decades. Further, an overview of the GBR research history is provided with specific focus on the evidence available on its effectiveness and predictability in promoting the regeneration of critical size cranio‐maxillo‐facial defects, the neo‐osteogenesis potential and the reconstruction of atrophic alveolar ridges before, or in conjunction with, the placement of dental implants. The authors conclude that future research should focus on (a) the investigation of the molecular mechanisms underlying the wound healing process following GBR application; (b) the identification of site and patient related factors which impact on the effectiveness and predictability of GBR therapy and (c) the evaluation of the pathophysiology of the GBR healing process in the presence of systemic conditions potentially affecting the skeletal system. To cite this article: Retzepi M, Donos N. Guided Bone Regeneration: biological principle and therapeutic applications. Clin. Oral Impl. Res. 21, 2010; 567–576. doi: 10.1111/j.1600‐0501.2010.01922.x

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Metadata

Authors
Retzepi, M., & Donos, N.
Venue
Clinical Oral Implants Research
Publisher
Wiley
Published
2010-05-11
Volume
21
Issue
6
Pages
567-576
ISSN
  • 0905-7161 (ISSN-L)
  • 1600-0501
OpenAlex
W2126497169
Cited by
659
References
36
FWCI
19.22
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Guided Bone Regeneration: biological principle and therapeutic applications. https://app.cochat.ai/papers/10.1111/j.1600-0501.2010.01922.x
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Retzepi, M., & Donos, N. (2010). Guided Bone Regeneration: biological principle and therapeutic applications. Clinical Oral Implants Research. https://doi.org/10.1111/j.1600-0501.2010.01922.x

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.