The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Reversibility of experimental peri‐implant mucositis compared with experimental gingivitis in humans
Abstract
Objective: To monitor clinical, microbiological and host‐derived alterations occurring around teeth and titanium implants during the development of experimental gingivitis/mucositis and their respective healing sequence in humans. Material and methods: Fifteen subjects with healthy or treated periodontal conditions and restored with dental implants underwent an experimental 3‐week period of undisturbed plaque accumulation in the mandible. Subsequently, a 3‐week period with optimal plaque control was instituted. At Days 0, 7, 14, 21, 28, 35 and 42, the presence/absence of plaque deposits around teeth and implants was assessed, (plaque index [PlI]) and the gingival/mucosal conditions were evaluated (gingival index[GI]). Subgingival/submucosal plaque samples and gingival/mucosal crevicular fluid (CF) samples were collected from two pre‐determined sites around each experimental unit. CF samples were analyzed for matrix‐metalloproteinase‐8 (MMP‐8) and interleukin‐1beta (IL‐1β). Microbial samples were analyzed using DNA–DNA hybridization for 40 species. Results: During 3 weeks of plaque accumulation, the median PlI and GI increased significantly at implants and teeth. Implant sites yielded a greater increase in the median GI compared with tooth sites. Over the 6‐week experimental period, the CF levels of MMP‐8 were statistically significantly higher at implants compared with teeth (P<0.05). The CF IL‐1β levels did not differ statistically significantly between teeth and implants (P>0.05). No differences in the total DNA counts between implant and tooth sites were found at any time points. No differences in the detection frequency were found for putative periodontal pathogens between implant and tooth sites. Conclusion: Peri‐implant soft tissues developed a stronger inflammatory response to experimental plaque accumulation when compared with that of their gingival counterparts. Experimental gingivitis and peri‐implant mucositis were reversible at the biomarker level. Clinically, however, 3 weeks of resumed plaque control did not yield pre‐experimental levels of gingival and peri‐implant mucosal health indicating that longer healing periods are needed. To cite this article: Salvi GE, Aglietta M, Eick S, Sculean A, Lang NP & Ramseier CA. Reversibility of experimental peri‐implant mucositis compared with experimental gingivitis in humans. Clin. Oral Impl. Res. 23, 2012; 182–190. doi: 10.1111/j.1600‐0501.2011.02220.x
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Cites
Periodontal Disease in Pregnancy II. Correlation Between Oral Hygiene and Periodontal Condition
Silness, J., & Löe, H. (1964) · Acta Odontologica Scandinavica · doi:10.3109/00016356408993968 · Cited by 7,932
Experimental gingivitis in man
Löe, H., Theilade, E., & Jensen, S. B. (1965) · The Journal of Periodontology · doi:10.1902/jop.1965.36.3.177 · Cited by 3,481 · cited 1×
“Experimental studies in man and animal models provided evidence that gingivitis and periodontitis are dependent upon the presence of a bacterial biofilm on the tooth surfaces and the adjacent gingival margins (Löe et al. 1965).”
BackgroundExperimental gingivitis in man: II. A Longitudinal Clinical and Bacteriological Investigation
Theilade, E., Wright, W. H., Jensen, S. B., & Löe, H. (1966) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.1966.tb01842.x · Cited by 1,038
Cited by
Schwarz, F., Derks, J., Monje, A., & Wang, H. (2018) · Journal of Clinical Periodontology · doi:10.1111/jcpe.12954 · Cited by 1,066
Lang, N. P., Berglundh, T., & on Behalf of Working Group 4 of the Seventh European Workshop on Periodontology (2011) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2010.01674.x · Cited by 930
Self-citationSchwarz, F., Derks, J., Monje, A., & Wang, H. (2018) · Journal of Periodontology · doi:10.1002/jper.16-0350 · Cited by 723
Primary prevention of peri‐implantitis: Managing peri‐implant mucositis
Jepsen, S., Berglundh, T., Genco, R., Aass, A. M., Demirel, K., Derks, J., Figuero, E., Giovannoli, J. L., Goldstein, M., Lambert, F., et al. (2015) · Journal of Clinical Periodontology · doi:10.1111/jcpe.12369 · Cited by 592
Self-citationPrevention and treatment of peri‐implant diseases—The EFP S3 level clinical practice guideline
Herrera, D., Berglundh, T., Schwarz, F., Chapple, I., Jepsen, S., Sculean, A., Kebschull, M., Papapanou, P. N., Tonetti, M. S., Sanz, M., et al. (2023) · Journal of Clinical Periodontology · doi:10.1111/jcpe.13823 · Cited by 505
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Metadata
- Authors
- Salvi, G. E., Aglietta, M., Eick, S., Sculean, A., Lang, N. P., & Ramseier, C. A.
- Venue
- Clinical Oral Implants Research
- Publisher
- Wiley
- Published
- 2011-08-02
- Volume
- 23
- Issue
- 2
- Pages
- 182-190
- ISSN
- 0905-7161 (ISSN-L)
- 1600-0501
- OpenAlex
- W2154592680
- Cited by
- 380
- References
- 3
- FWCI
- 12.35
- Type
- journal article
- Language
- en
- Open access
- closed
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- Salvi, G. E., Aglietta, M., Eick, S., Sculean, A., Lang, N. P., & Ramseier, C. A. (2012). Reversibility of experimental peri‐implant mucositis compared with experimental gingivitis in humans. Clinical Oral Implants Research. https://doi.org/10.1111/j.1600-0501.2011.02220.x
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