Peri‐implantitis

Schwarz, Frank; Derks, Jan; Monje, Alberto; Wang, Hom‐Lay

doi:10.1002/jper.16-0350

Cited by 755Dental Implant Techniques and OutcomesOral microbiology and periodontitis researchPeriodontal Regeneration and Treatments

Peri‐implantitis

Open access

Schwarz, Frank, Derks, Jan, Monje, Alberto, Wang, Hom‐Lay·2018·Journal of Periodontology

DOI 10.1002/jper.16-0350

Open this paper in CoChat — free account Open PDF

Abstract

Objectives: This narrative review provides an evidence‐based overview on peri‐implantitis for the 2017 World Workshop on the Classification of Periodontal and Peri‐Implant Diseases and Conditions. Methods: A literature review was conducted addressing the following topics: 1) definition of peri‐implantitis; 2) conversion from peri‐implant mucositis to peri‐implantitis, 3) onset and pattern of disease progression, 4) characteristics of peri‐implantitis, 5) risk factors/indicators for peri‐implantitis, and 6) progressive crestal bone loss in the absence of soft tissue inflammation. Conclusions: Peri‐implantitis is a pathological condition occurring in tissues around dental implants, characterized by inflammation in the peri‐implant connective tissue and progressive loss of supporting bone. The histopathologic and clinical conditions leading to the conversion from peri‐implant mucositis to peri‐implantitis are not completely understood. The onset of peri‐implantitis may occur early during follow‐up and the disease progresses in a non‐linear and accelerating pattern. Peri‐implantitis sites exhibit clinical signs of inflammation and increased probing depths compared to baseline measurements. At the histologic level, compared to periodontitis sites, peri‐implantitis sites often have larger inflammatory lesions. Surgical entry at peri‐implantitis sites often reveals a circumferential pattern of bone loss. There is strong evidence that there is an increased risk of developing peri‐implantitis in patients who have a history of chronic periodontitis, poor plaque control skills, and no regular maintenance care after implant therapy. Data identifying “smoking” and “diabetes” as potential risk factors/indicators for peri‐implantitis are inconclusive. There is some limited evidence linking peri‐implantitis to other factors such as: post‐restorative presence of submucosal cement, lack of peri‐implant keratinized mucosa and positioning of implants that make it difficult to perform oral hygiene and maintenance. Evidence suggests that progressive crestal bone loss around implants in the absence of clinical signs of soft tissue inflammation is a rare event.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1002/jper.16-0350

Cites

165 of 165 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The onset of peri-implantitis may occur early following implant placement as indicated by radiographic data.
“The onset of peri-implantitis may occur early following implant placement as indicated by radiographic data.”
From A new classification scheme for periodontal and peri‐implant diseases and conditions – Introduction and key changes from the 1999 classification (2018) · cites this paper as [29]
Peri-implantitis, in the absence of treatment, seems to progress in a non-linear and accelerating pattern.
“Peri-implantitis, in the absence of treatment, seems to progress in a non-linear and accelerating pattern.29”
From A new classification scheme for periodontal and peri‐implant diseases and conditions – Introduction and key changes from the 1999 classification (2018) · cites this paper as [29]
Peri-implantitis is associated with poor plaque control and with patients with a history of severe periodontitis.
“Peri-implantitis is associated with poor plaque control and with patients with a history of severe periodontitis.”
From A new classification scheme for periodontal and peri‐implant diseases and conditions – Introduction and key changes from the 1999 classification (2018) · cites this paper as [29]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Global estimates of the prevalence of diabetes for 2010 and 2030
Shaw, J. E., Sicree, R. A., & Zimmet, P. Z. (2010) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2009.10.007 · Cited by 7,216 · see citing works
Global Burden of Severe Periodontitis in 1990-2010: A Systematic Review and Meta-regression
Kassebaum, N. J., Bernabé, E., Dahiya, M., Bhandari, B., Murray, C. J. L., & Marcenes, W. (2014) · Journal of Dental Research · doi:10.1177/0022034514552491 · Cited by 2,209 · see citing works
Peri‐implant diseases: Consensus Report of the Sixth European Workshop on Periodontology
Lindhe, J., Meyle, J., & on behalf of Group D of the European Workshop on Periodontology (2008) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2008.01283.x · Cited by 1,490 · see citing works
Update on Prevalence of Periodontitis in Adults in the United States: NHANES 2009 – 2012
Eke, P., Dye, B., Wei, L., Slade, G., Thornton-Evans, G., Borgnakke, W., Taylor, G., Page, R., Beck, J., & Genco, R. (2015) · The Journal of Periodontology · doi:10.1902/jop.2015.140520 · Cited by 1,442 · see citing works
Risk factors for periodontal disease
Genco, R. J., & Borgnakke, W. S. (2013) · Periodontology 2000 · doi:10.1111/j.1600-0757.2012.00457.x · Cited by 1,257 · see citing works
Smoking‐Attributable Periodontitis in the United States: Findings From NHANES III
Tomar, S. L., & Asma, S. (2000) · Journal of Periodontology · doi:10.1902/jop.2000.71.5.743 · Cited by 1,002 · see citing works
Periimplant diseases: where are we now?--Consensus of the Seventh European Workshop on Periodontology
Lang, N. P., Berglundh, T., & on Behalf of Working Group 4 of the Seventh European Workshop on Periodontology (2011) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2010.01674.x · Cited by 930 · see citing works
The long‐term effect of a plaque control program on tooth mortality, caries and periodontal disease in adults
Axelsson, P., Nyström, B., & Lindhe, J. (2004) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2004.00563.x · Cited by 902 · see citing works
A prospective 15‐year follow‐up study of mandibular fixed prostheses supported by osseointegrated implants. Clinical results and marginal bone loss.
Lindquist, L. W., Carlsson, G. E., & Jemt, T. (1996) · Clinical Oral Implants Research · doi:10.1034/j.1600-0501.1996.070405.x · Cited by 700 · see citing works
Experimental breakdown of peri‐implant and periodontal tissues. A study in the beagle dog
Lindhe, J., Berglundh, T., Ericsson, I., Liljenberg, B., & Marinello, C. P. (1992) · Clinical Oral Implants Research · doi:10.1034/j.1600-0501.1992.030102.x · Cited by 667 · see citing works
Effect of controlled oral hygiene procedures on caries and periodontal disease in adults
Axelsson, P., & Lindhe, J. (1978) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.1978.tb01914.x · Cited by 625 · see citing works
The significance of maintenance care in the treatment of periodontal disease
Axelsson, P., & Lindhe, J. (1981) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.1981.tb02039.x · Cited by 618 · see citing works
Long‐term implant prognosis in patients with and without a history of chronic periodontitis: a 10‐year prospective cohort study of the ITI® Dental Implant System
Karoussis, I. K., Salvi, G. E., Heitz‐Mayfield, L. J. A., Brägger, U., Hämmerle, C. H. F., & Lang, N. P. (2003) · Clinical Oral Implants Research · doi:10.1034/j.1600-0501.000.00934.x · Cited by 610 · see citing works
Effectiveness of Implant Therapy Analyzed in a Swedish Population
Derks, J., Schaller, D., Håkansson, J., Wennström, J. L., Tomasi, C., & Berglundh, T. (2015) · Journal of Dental Research · doi:10.1177/0022034515608832 · Cited by 609 · see citing works
Self-citation
The Positive Relationship Between Excess Cement and Peri‐Implant Disease: A Prospective Clinical Endoscopic Study
Wilson, T. G. (2009) · Journal of Periodontology · doi:10.1902/jop.2009.090115 · Cited by 601 · see citing works
Primary prevention of peri‐implantitis: Managing peri‐implant mucositis
Jepsen, S. V., Berglundh, T., Genco, R. J., Aass, A. M., Demirel, K., Derks, J., Figuero, E., Giovannoli, J., Goldstein, M., Lambert, F., et al. (2015) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.12369 · Cited by 592 · see citing works
Self-citation
Periodontal disease: associations with diabetes, glycemic control and complications
Taylor, G., & Borgnakke, W. S. (2008) · Oral Diseases · doi:10.1111/j.1601-0825.2008.01442.x · Cited by 591 · see citing works
Nine‐ to fourteen‐year follow‐up of implant treatment. Part II: presence of peri‐implant lesions
Roos‐Jansåker, A., Lindahl, C., Renvert, H., & Renvert, S. (2006) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2006.00906.x · Cited by 572 · see citing works
Experimentally induced peri‐implant mucositis. A clinical study in humans.
Pontoriero, R., Tonelli, M., Carnevale, G., Mombelli, A., Nyman, S. R., & Lang, N. P. (1994) · Clinical Oral Implants Research · doi:10.1034/j.1600-0501.1994.050409.x · Cited by 553 · see citing works
Prevalence and risk variables for peri‐implant disease in Brazilian subjects
Ferreira, S. D., Silva, G. L. M., Cortelli, J. R., Costa, J. E., & Costa, F. O. (2006) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2006.01001.x · Cited by 550 · see citing works
Clinical research on peri‐implant diseases: consensus report of W orking G roup 4
Sanz, M., Chapple, I., & on behalf of Working Group 4 of the VIII European Workshop on Periodontology (2012) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2011.01837.x · Cited by 520 · see citing works
Microbial findings at failing implants
Leonhardt, Å., Renvert, S., & Dahlén, G. (1999) · Clinical Oral Implants Research · doi:10.1034/j.1600-0501.1999.100501.x · Cited by 507 · see citing works
The Significance of Keratinized Mucosa on Implant Health: A Systematic Review
Lin, G., Chan, H., & Wang, H. (2013) · Journal of Periodontology · doi:10.1902/jop.2013.120688 · Cited by 500 · see citing works
Self-citation
Peri‐implant disease in subjects with and without preventive maintenance: a 5‐year follow‐up
Costa, F. O., Martínez, S. T., Cota, L. O. M., Ferreira, S. D., Silva, G. L. M., & Costa, J. E. (2011) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2011.01819.x · Cited by 494 · see citing works
The Natural History of Periodontal Disease in Man: The Rate of Periodontal Destruction Before 40 Years of Age
Löe, H. A., Ånerud, Å., Boysen, H., & Smith, M. R. (1978) · Journal of Periodontology · doi:10.1902/jop.1978.49.12.607 · Cited by 471 · see citing works
Prevalence of Peri‐Implantitis Related to Severity of the Disease With Different Degrees of Bone Loss
Koldsland, O. C., Scheie, A. A., & Aass, A. M. (2010) · Journal of Periodontology · doi:10.1902/jop.2009.090269 · Cited by 435 · see citing works
Nine‐ to fourteen‐year follow‐up of implant treatment. Part III: factors associated with peri‐implant lesions
Roos‐Jansåker, A., Renvert, H., Lindahl, C., & Renvert, S. (2006) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2006.00908.x · Cited by 429 · see citing works
Peri‐implantitis in partially edentulous patients: association with inadequate plaque control
Serino, G., & Ström, C. (2008) · Clinical Oral Implants Research · doi:10.1111/j.1600-0501.2008.01627.x · Cited by 424 · see citing works
Different types of inflammatory reactions in peri‐implant soft tissues
Ericsson, I., Persson, L. G., Berglundh, T., Marinello, C. P., Lindhe, J., & Klinge, B. (1995) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.1995.tb00143.x · Cited by 420 · see citing works
The characteristics of biofilms in peri‐implant disease
Mombelli, A., & Décaillet, F. (2011) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2010.01666.x · Cited by 416 · see citing works
Soft tissue reaction to de novo plaque formation on implants and teeth. An experimental study in the dog
Berglundh, T., Lindhe, J., Marinell, C., Ericsson, I., & Liljenberg, B. (1992) · Clinical Oral Implants Research · doi:10.1034/j.1600-0501.1992.030101.x · Cited by 408 · see citing works
Reversibility of experimental peri‐implant mucositis compared with experimental gingivitis in humans
Salvi, G. E., Aglietta, M., Eick, S., Sculean, A., Lang, N. P., & Ramseier, C. A. (2011) · Clinical Oral Implants Research · doi:10.1111/j.1600-0501.2011.02220.x · Cited by 378 · see citing works
Are peri‐implantitis lesions different from periodontitis lesions?
Berglundh, T., Zitzmann, N. U., & Donati, M. (2011) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2010.01672.x · Cited by 363 · see citing works
Composition of Human Peri-implantitis and Periodontitis Lesions
Carcuac, O., & Berglundh, T. (2014) · Journal of Dental Research · doi:10.1177/0022034514551754 · Cited by 359 · see citing works
Prevalence of subjects with progressive bone loss at implants
Fransson, C., Lekholm, U., Jemt, T., & Berglundh, T. (2005) · Clinical Oral Implants Research · doi:10.1111/j.1600-0501.2005.01137.x · Cited by 344 · see citing works
Peri‐implantitis – onset and pattern of progression
Derks, J., Schaller, D., Håkansson, J., Wennström, J. L., Tomasi, C., & Berglundh, T. (2016) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.12535 · Cited by 339 · see citing works
Self-citation
Cluster of Bacteria Associated with Peri‐Implantitis
Persson, G. R., & Renvert, S. (2013) · Clinical Implant Dentistry and Related Research · doi:10.1111/cid.12052 · Cited by 338 · see citing works
Heat caused by drilling cortical bone: Temperature measured in vivo in patients and animals
Eriksson, A. R., Albrektsson, T. O., & Albrektsson, B. (1984) · Acta Orthopaedica Scandinavica · doi:10.3109/17453678408992410 · Cited by 338 · see citing works
Experimental peri‐implant mucositis in man
Zitzmann, N. U., Berglundh, T., Marinello, C. P., & Lindhe, J. (2001) · Journal Of Clinical Periodontology · doi:10.1034/j.1600-051x.2001.028006517.x · Cited by 315 · see citing works
Does residual cement around implant‐supported restorations cause peri‐implant disease? A retrospective case analysis
Linkevičius, T., Puišys, A., Vindašiūtė, E., Linkevičienė, L., & Apse, P. (2012) · Clinical Oral Implants Research · doi:10.1111/j.1600-0501.2012.02570.x · Cited by 314 · see citing works
Long‐standing plaque and gingivitis at implants and teeth in the dog
Ericsson, I., Berglundh, T., Marinello, C. P., Liljenberg, B., & Lindhe, J. (1992) · Clinical Oral Implants Research · doi:10.1034/j.1600-0501.1992.030301.x · Cited by 309 · see citing works
Prevalence and Predictive Factors for Peri‐Implant Disease and Implant Failure: A Cross‐Sectional Analysis
Daubert, D. M., Weinstein, B. F., Bordin, S., Leroux, B. G., & Flemmig, T. F. (2014) · Journal of Periodontology · doi:10.1902/jop.2014.140438 · Cited by 308 · see citing works
Relationship between smoking and dental status in 35‐, 50‐, 65‐, and 75‐year‐old individuals
Axelsson, P., Paulartder, J., & Lindhe, J. (1998) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.1998.tb02444.x · Cited by 301 · see citing works
Prevalence of periimplant disease in partially edentulous patients: a practice-based cross-sectional study
Rinke, S., Ohl, S., Ziebolz, D., Lange, K., & Eickholz, P. (2010) · Clinical Oral Implants Research · doi:10.1111/j.1600-0501.2010.02061.x · Cited by 289 · see citing works
Implant micromotion is related to peak insertion torque and bone density
Trisi, P., Perfetti, G., Baldoni, E., Berardi, D., Colagiovanni, M., & Scogna, G. (2009) · Clinical Oral Implants Research · doi:10.1111/j.1600-0501.2008.01679.x · Cited by 286 · see citing works
Histologic probe penetration in healthy and inflamed peri‐implant tissues
Lang, N. P., Wetzel, A., Stich, H., & Caffesse, R. G. (1994) · Clinical Oral Implants Research · doi:10.1034/j.1600-0501.1994.050401.x · Cited by 272 · see citing works
Periodontal Treatment Without Maintenance: A Retrospective Study in 44 Patients
Becker, W., Becker, B. E., & Berg, L. E. (1984) · Journal of Periodontology · doi:10.1902/jop.1984.55.9.505 · Cited by 261 · see citing works
Excess cement and the risk of peri‐implant disease – a systematic review
Staubli, N., Walter, C., Schmidt, J. C., Weiger, R., & Zitzmann, N. U. (2016) · Clinical Oral Implants Research · doi:10.1111/clr.12954 · Cited by 258 · see citing works
Infection at titanium implants with or without a clinical diagnosis of inflammation
Renvert, S., Roos‐Jansåker, A. M., Lindahl, C., Renvert, H., & Persson, G. R. (2007) · Clinical Oral Implants Research · doi:10.1111/j.1600-0501.2007.01378.x · Cited by 254 · see citing works
Is there a need for keratinized mucosa around implants to maintain health and tissue stability?
Wennström, J. L., & Derks, J. B. (2012) · Clinical Oral Implants Research · doi:10.1111/j.1600-0501.2012.02540.x · Cited by 249 · see citing works
Self-citation
Influence of Soft Tissue Thickness on Peri‐Implant Marginal Bone Loss: A Systematic Review and Meta‐Analysis
Suárez, F., Lin, G., Monje, A., Galindo‐Moreno, P., & Wang, H. (2016) · Journal of Periodontology · doi:10.1902/jop.2016.150571 · Cited by 249 · see citing works
Self-citation
Keratinized mucosa around implants in partially edentulous posterior mandible: 10‐year results of a prospective comparative study
Roccuzzo, M., Grasso, G., & Dalmasso, P. (2015) · Clinical Oral Implants Research · doi:10.1111/clr.12563 · Cited by 247 · see citing works
The influence of bacteria and irritation in the initiation of periodontal disease in germfree and conventional rats
Rovin, S., Costich, E. R., & Gordon, H. A. (1966) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.1966.tb01860.x · Cited by 245 · see citing works
Risk indicators for Peri‐implantitis. A cross‐sectional study with 916 implants
Dalago, H. R., Filho, G. S., Rodrigues, M. A. P., Renvert, S., & Bianchini, M. A. (2016) · Clinical Oral Implants Research · doi:10.1111/clr.12772 · Cited by 242 · see citing works
Ten‐year results of a three‐arm prospective cohort study on implants in periodontally compromised patients. Part 1: implant loss and radiographic bone loss
Roccuzzo, M., Angelis, N. D., Bonino, L., & Aglietta, M. (2010) · Clinical Oral Implants Research · doi:10.1111/j.1600-0501.2009.01886.x · Cited by 236 · see citing works
Comparison of naturally occurring and ligature‐induced peri‐implantitis bone defects in humans and dogs
Schwarz, F., Herten, M., Sager, M., Bieling, K., Sculean, A., & Becker, J. (2006) · Clinical Oral Implants Research · doi:10.1111/j.1600-0501.2006.01320.x · Cited by 231 · see citing works
Self-citation
Genetic factors in the pathogenesis of periodontitis
Hart, T. C., & Kornman, K. S. (1997) · Periodontology 2000 · doi:10.1111/j.1600-0757.1997.tb00198.x · Cited by 227 · see citing works
Clinical characteristics at implants with a history of progressive bone loss
Fransson, C., Wennström, J. L., & Berglundh, T. (2008) · Clinical Oral Implants Research · doi:10.1111/j.1600-0501.2007.01448.x · Cited by 218 · see citing works
Foreign Bodies Associated With Peri‐Implantitis Human Biopsies
Wilson, T. G., Valderrama, P., Burbano, M., Blansett, J. A., Levine, R. A., Kessler, H. P., & Rodrigues, D. C. (2014) · Journal of Periodontology · doi:10.1902/jop.2014.140363 · Cited by 207 · see citing works
IL‐1RN gene polymorphism is associated with peri‐implantitis
Laine, M. L., Leonhardt, Å., Roos‐Jansåker, A., Peña, A. S., Winkelhoff, A. J. V., Winkel, E. G., & Renvert, S. (2006) · Clinical Oral Implants Research · doi:10.1111/j.1600-0501.2006.01249.x · Cited by 204 · see citing works
Prevalence and risk factors for peri‐implant disease in Belgian adults
Marrone, A., Lasserre, J. F., Bercy, P., & Brecx, M. (2012) · Clinical Oral Implants Research · doi:10.1111/j.1600-0501.2012.02476.x · Cited by 201 · see citing works
The influence of peri‐implant keratinized mucosa on brushing discomfort and peri‐implant tissue health
Souza, A. B. D., Tormena, M., Matarazzo, F., & Araújo, M. G. (2015) · Clinical Oral Implants Research · doi:10.1111/clr.12703 · Cited by 201 · see citing works
Ten‐year results of a three arms prospective cohort study on implants in periodontally compromised patients. Part 2: clinical results
Roccuzzo, M., Bonino, F., Aglietta, M., & Dalmasso, P. (2011) · Clinical Oral Implants Research · doi:10.1111/j.1600-0501.2011.02309.x · Cited by 194 · see citing works
Peri-implantitis and late implant failures in postmenopausal women: a cross-sectional study
Dvorak, G., Arnhart, C., Heuberer, S., Huber, C. D., Watzek, G., & Gruber, R. (2011) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2011.01772.x · Cited by 192 · see citing works
Factors related to peri‐implantitis – a retrospective study
Renvert, S., Aghazadeh, A., Hallström, H., & Persson, G. R. (2013) · Clinical Oral Implants Research · doi:10.1111/clr.12208 · Cited by 191 · see citing works
The Effect of Keratinized Mucosa Width on Peri-implant Health: A Systematic Review
Gobbato, L., Ávila‐Ortiz, G., Sohrabi, K., Wang, C.-W., & Karimbux, N. Y. (2013) · The International Journal of Oral & Maxillofacial Implants · doi:10.11607/jomi.3244 · Cited by 187 · see citing works
Soft tissue response to plaque formation at different implant systems. A comparative study in the dog
Abrahamsson, L., Berglundh, T., & Lindhe, J. (1998) · Clinical Oral Implants Research · doi:10.1034/j.1600-0501.1998.090202.x · Cited by 186 · see citing works
Metal elements in tissue with dental peri‐implantitis: a pilot study
Fretwurst, T., Buzanich, G., Nahles, S., Woelber, J. P., Riesemeier, H., & Nelson, K. (2015) · Clinical Oral Implants Research · doi:10.1111/clr.12718 · Cited by 182 · see citing works
Impact of implant overloading on the peri‐implant bone in inflamed and non‐inflamed peri‐implant mucosa
Kozlovsky, A., Tal, H., Laufer, B., Leshem, R., Rohrer, M. D., Weinreb, M., & Artzi, Z. (2007) · Clinical Oral Implants Research · doi:10.1111/j.1600-0501.2007.01374.x · Cited by 180 · see citing works
Predisposing conditions for retrograde peri‐implantitis, and treatment suggestions
Quirynen, M., Vogels, R., Alsaadi, G., Naert, I. E., Jacobs, R., & van Steenberghe, D. (2005) · Clinical Oral Implants Research · doi:10.1111/j.1600-0501.2005.01147.x · Cited by 177 · see citing works
Probing around implants and teeth with healthy or inflamed peri‐implant mucosa/gingiva
Schou, S., Holmstrup, P., Stoltze, K., Hjørting-Hansen, E., Fiehn, N., & Skovgaard, L. T. (2002) · Clinical Oral Implants Research · doi:10.1034/j.1600-0501.2002.130201.x · Cited by 174 · see citing works
Experimental periodontitis and peri‐implantitis in dogs
Carcuac, O., Abrahamsson, I., Albouy, J., Linder, E., Larsson, L., & Berglundh, T. (2012) · Clinical Oral Implants Research · doi:10.1111/clr.12067 · Cited by 169 · see citing works
Does excessive occlusal load affect osseointegration? An experimental study in the dog
Heitz‐Mayfield, L. J. A., Schmid, B., Weigel, C., Gerber, S. M., Bosshardt, D. D., Jönsson, J., Lang, N. P., & Jönsson, J. (2004) · Clinical Oral Implants Research · doi:10.1111/j.1600-0501.2004.01019.x · Cited by 167 · see citing works
Exfoliative Cytology and Titanium Dental Implants: A Pilot Study
Olmedo, D. G., Nalli, G., Verdú, S. D., Paparella, M. L., & Cabrini, R. L. (2012) · Journal of Periodontology · doi:10.1902/jop.2012.110757 · Cited by 164 · see citing works
Cement‐associated peri‐implantitis: a retrospective clinical observational study of fixed implant‐supported restorations using a methacrylate cement
Korsch, M., Obst, U., & Walther, W. (2013) · Clinical Oral Implants Research · doi:10.1111/clr.12173 · Cited by 157 · see citing works
Immunohistochemical characteristics of inflammatory lesions at implants
Gualini, F., & Berglundh, T. (2003) · Journal Of Clinical Periodontology · doi:10.1034/j.1600-051x.2003.300103.x · Cited by 153 · see citing works
Spontaneous progression of ligatured induced peri‐implantitis at implants with different surface characteristics. An experimental study in dogs II: histological observations
Albouy, J., Abrahamsson, I., Persson, L. G., & Berglundh, T. (2009) · Clinical Oral Implants Research · doi:10.1111/j.1600-0501.2008.01645.x · Cited by 149 · see citing works
Clinical research of peri‐implant diseases – quality of reporting, case definitions and methods to study incidence, prevalence and risk factors of peri‐implant diseases
Tomasi, C., & Derks, J. (2012) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2011.01831.x · Cited by 149 · see citing works
Self-citation
Histopathological observations of human periimplantitis lesions
Berglundh, T., Gislason, Ö., Lekholm, U., Sennerby, L., & Lindhe, J. (2004) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2004.00486.x · Cited by 146 · see citing works
Impact of IL‐1 genotype and smoking status on the prognosis of osseointegrated implants
Gruica, B., Wang, H., Lang, N. P., & Buser, D. (2004) · Clinical Oral Implants Research · doi:10.1111/j.1600-0501.2004.01026.x · Cited by 145 · see citing works
Self-citation
Severity and pattern of peri‐implantitis‐associated bone loss
Fransson, C., Tomasi, C., Pikner, S. S., Gröndahl, K., Wennström, J. L., Leyland, A. H., & Berglundh, T. (2010) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2010.01537.x · Cited by 143 · see citing works
Association of Preventive Maintenance Therapy Compliance and Peri‐Implant Diseases: A Cross‐Sectional Study
Monje, A., Wang, H., & Nart, J. (2017) · Journal of Periodontology · doi:10.1902/jop.2017.170135 · Cited by 143 · see citing works
Self-citation
Tooth Loss in Maintenance Patients in a Private Periodontal Practice
Wilson, T. G., Glover, M. E., Malik, A. K., Schoen, J. A., & Dorsett, D. (1987) · Journal of Periodontology · doi:10.1902/jop.1987.58.4.231 · Cited by 142 · see citing works
The association between selected risk indicators and severity of peri-implantitis using mixed model analyses
Koldsland, O. C., Scheie, A. A., & Aass, A. M. (2010) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2010.01659.x · Cited by 138 · see citing works
Distinguishing predictive profiles for patient‐based risk assessment and diagnostics of plaque induced, surgically and prosthetically triggered peri‐implantitis
Canullo, L., Tallarico, M., Radovanović, S., Delibašić, B., Covani, U., & Rakić, M. (2015) · Clinical Oral Implants Research · doi:10.1111/clr.12738 · Cited by 136 · see citing works
Development and treatment of retrograde peri-implantitis involving a site with a history of failed endodontic and apicoectomy procedures: a series of reports.
Ayangco, L., & Sheridan, P. J. (2001) · PubMed · Cited by 135 · see citing works
Implant Compression Necrosis: Current Understanding and Case Report
Bashutski, J. D., D’Silva, N. J., & Wang, H. (2009) · Journal of Periodontology · doi:10.1902/jop.2009.080581 · Cited by 134 · see citing works
Self-citation
Soft tissue reactions to plaque formation at implant abutments with different surface topography
Zitzmann, N. U., Abrahamsson, I., Berglundh, T., & Lindhe, J. (2002) · Journal Of Clinical Periodontology · doi:10.1034/j.1600-051x.2002.290511.x · Cited by 133 · see citing works
Spontaneous progression of experimental peri‐implantitis at implants with different surface characteristics: An experimental study in dogs
Jean‐Pierre Albouy, Abrahamsson, I., & Berglundh, T. (2011) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2011.01820.x · Cited by 132 · see citing works
Could cytokine levels in the peri‐implant crevicular fluid be used to distinguish between healthy implants and implants with peri‐implantitis? A systematic review
Duarte, P. M., Serrão, C. R., Miranda, T. S., Zanatta, L. C. S., Bastos, M. F., Faveri, M., Figueiredo, L. C., & Feres, M. (2016) · Journal of Periodontal Research · doi:10.1111/jre.12354 · Cited by 132 · see citing works
Clinical and microbiological findings in patients with peri‐implantitis: a cross‐sectional study
Canullo, L., Peñarrocha‐Oltra, D., Covani, U., Botticelli, D., Serino, G., & Diago, M. P. (2015) · Clinical Oral Implants Research · doi:10.1111/clr.12557 · Cited by 131 · see citing works
Probing at implants with peri‐implantitis and its relation to clinical peri‐implant bone loss
Serino, G., Turri, A., & Lang, N. P. (2012) · Clinical Oral Implants Research · doi:10.1111/j.1600-0501.2012.02470.x · Cited by 131 · see citing works
Conventional and advanced implant treatment in the type II diabetic patient: surgical protocol and long-term clinical results.
Tawil, G., Younan, R., Azar, P., & Sleilati, G. (2008) · PubMed · Cited by 127 · see citing works
Prevalence of peri‐implantitis in patients not participating in well‐designed supportive periodontal treatments: a cross‐sectional study
Rokn, A., Aslroosta, H., Akbari, S., Najafi, H., Zayeri, F., & Hashemi, K. (2016) · Clinical Oral Implants Research · doi:10.1111/clr.12800 · Cited by 125 · see citing works
Prevalence of peri‐implant inflammatory disease in patients with a history of periodontal disease who receive supportive periodontal therapy
Aguirre-Zorzano, L.-A., Estefanía‐Fresco, R., Agirre, O. T., & Bravo, M. (2014) · Clinical Oral Implants Research · doi:10.1111/clr.12462 · Cited by 123 · see citing works
The Microbiologic Profile Associated with Peri-Implantitis in Humans: A Systematic Review
Rakić, M., Grusovin, M. G., & Canullo, L. (2015) · The International Journal of Oral & Maxillofacial Implants · doi:10.11607/jomi.4150 · Cited by 120 · see citing works
Can Peri‐Implant Crevicular Fluid Assist in the Diagnosis of Peri‐Implantitis? A Systematic Review and Meta‐Analysis
Faot, F., Nascimento, G. G., Bielemann, A. M., Campão, T. D., Leite, F. R. M., & Quirynen, M. (2015) · Journal of Periodontology · doi:10.1902/jop.2015.140603 · Cited by 119 · see citing works
Impact of implant–abutment connection and positioning of the machined collar/microgap on crestal bone level changes: a systematic review
Schwarz, F., Hegewald, A., & Becker, J. C. (2013) · Clinical Oral Implants Research · doi:10.1111/clr.12215 · Cited by 114 · see citing works
Self-citation
The prevalence of peri‐implant diseases for two‐piece implants with an internal tube‐in‐tube connection: a cross‐sectional analysis of 512 implants
Schwarz, F., Becker, K., Sahm, N., Horstkemper, T., Rousi, K., & Becker, J. C. (2015) · Clinical Oral Implants Research · doi:10.1111/clr.12609 · Cited by 109 · see citing works
Self-citation
Microbial differences in 2 clinically distinct types of failures of osseointegrated implants
Sanz, M., Alández, J., Lázaro, P., Calvo, J. L., Quirynen, M., & van Steenberghe, D. (1991) · Clinical Oral Implants Research · doi:10.1034/j.1600-0501.1991.020305.x · Cited by 109 · see citing works
Assessment of periodontal and opportunistic flora in patients with peri‐implantitis
Albertini, M., López‐Cerero, L., O'Sullivan, M. G., Chereguini, C. F., Ballesta, S., Ríos-Santos, J., Herrero‐Climent, M., & Bullón, P. (2014) · Clinical Oral Implants Research · doi:10.1111/clr.12387 · Cited by 106 · see citing works
Impact of the outcome of guided bone regeneration in dehiscence‐type defects on the long‐term stability of peri‐implant health: clinical observations at 4 years
Schwarz, F., Sahm, N., & Becker, J. C. (2011) · Clinical Oral Implants Research · doi:10.1111/j.1600-0501.2011.02214.x · Cited by 104 · see citing works
Self-citation
Immunohistochemical analysis of soft tissues in implants with healthy and peri‐implantitis condition, and aggressive periodontitis
Bullón, P., Fioroni, M., Goteri, G., Rubini, C., & Battino, M. A. (2004) · Clinical Oral Implants Research · doi:10.1111/j.1600-0501.2004.01072.x · Cited by 99 · see citing works
Immunohistochemical evaluation of inflammatory mediators in failing implants.
Konttinen, Y. T., Lappalainen, R., Laine, P. O., Kitti, U., Santavirta, S. S., & Teronen, O. P. (2006) · PubMed · Cited by 94 · see citing works
Clinical course of chronic periodontitis
Schätzle, M. A., Löe, H. A., Lang, N. P., Heitz‐Mayfield, L. J. A., Bürgin, W., Ånerud, Å., & Boysen, H. (2003) · Journal Of Clinical Periodontology · doi:10.1034/j.1600-051x.2003.00401.x · Cited by 91 · see citing works
Identification of Periodontal Pathogens in Healthy Periimplant Sites
Casado, P. L., Otazu, I. B., Balduíno, A., de Mello, W., Barboza, E. P., & Duarte, M. E. L. (2011) · Implant Dentistry · doi:10.1097/id.0b013e3182199348 · Cited by 90 · see citing works
Associations between peri‐implant crevicular fluid volume, concentrations of crevicular inflammatory mediators, and composite IL‐1A –889 and IL‐1B +3954 genotype: A cross‐sectional study on implant recall patients with and without clinical signs of peri‐implantitis
Lachmann, S., Kimmerle-Mueller, E., Axmann, D., Scheideler, L., Weber, H., & Haas, R. (2007) · Clinical Oral Implants Research · doi:10.1111/j.1600-0501.2006.01322.x · Cited by 83 · see citing works
Accuracy of periapical radiography in assessing bone level in implants affected by peri‐implantitis: a cross‐sectional study
García‐García, M., Mir‐Mari, J., Benić, G. I., Figueiredo, R., & Valmaseda‐Castellón, E. (2015) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.12491 · Cited by 82 · see citing works
Animal models for peri‐implant mucositis and peri‐implantitis
Schwarz, F., Sculean, A., Engebretson, S. P., Becker, J. R., & Sager, M. (2015) · Periodontology 2000 · doi:10.1111/prd.12064 · Cited by 77 · see citing works
Self-citation
Is the presence of keratinized mucosa associated with periimplant tissue health? A clinical cross-sectional analysis
Ladwein, C., Schmelzeisen, R., Nelson, K., Flügge, T. V., & Fretwurst, T. (2015) · International Journal of Implant Dentistry · doi:10.1186/s40729-015-0009-z · Cited by 76 · see citing works
Peri-Implant Diseases May Be Associated With Increased Time Loading and Generalized Periodontal Bone Loss: Preliminary Results
Máximo, M. B. B., de Mendonça, A. C., Alves, J. F., Cortelli, S. C., Peruzzo, D. C., & Duarte, P. M. (2008) · Journal of Oral Implantology · doi:10.1563/1548-1336(2008)34[269:pdmbaw]2.0.co;2 · Cited by 74 · see citing works
Into the Paradigm of Local Factors as Contributors for Peri-implant Disease: Short Communication
Monje, A., Galindo‐Moreno, P., Tözüm, T. F., Suárez, F., & Wang, H. (2016) · The International Journal of Oral & Maxillofacial Implants · doi:10.11607/jomi.4265 · Cited by 74 · see citing works
Self-citation
Bone reactions at implants subjected to experimental peri‐implantitis and static load
Gotfredsen, K., Berglundh, T., & Lindhe, J. (2002) · Journal Of Clinical Periodontology · doi:10.1034/j.1600-051x.2002.290209.x · Cited by 73 · see citing works
Peri‐implant bone loss in cement‐ and screw‐retained prostheses: Systematic review and meta‐analysis
de Brandão, M. L., Vettore, M. V., & Vidigal, G. M. (2012) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.12041 · Cited by 73 · see citing works
A smart insulin patch
Omid Veiseh, A., & Langer, R. (2015) · Nature · doi:10.1038/524039a · Cited by 72 · see citing works
Peri‐Implantitis Associated with Type of Cement: A Retrospective Analysis of Different Types of Cement and Their Clinical Correlation to the Peri‐Implant Tissue
Korsch, M., & Walther, W. (2014) · Clinical Implant Dentistry and Related Research · doi:10.1111/cid.12265 · Cited by 71 · see citing works
Mucosal inflammation and incidence of crestal bone loss among implant patients: a 10‐year study
Cecchinato, D., Parpaiola, A., & Lindhe, J. (2013) · Clinical Oral Implants Research · doi:10.1111/clr.12209 · Cited by 68 · see citing works
Experimental peri‐implant mucositis at different implant surfaces
Schwarz, F., Mihatovic, I., Golubovic, V., Eick, S., Iglhaut, T., & Becker, J. R. (2014) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.12240 · Cited by 63 · see citing works
Self-citation
Diagnosis and treatment of a large periapical implant lesion associated with adjacent natural tooth: A case report
Tözüm, T. F., Şençimen, M., Ortakoğlu, K., Özdemir, A., Aydin, Ö. C., & Keleş, M. (2006) · Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology · doi:10.1016/j.tripleo.2005.11.029 · Cited by 62 · see citing works
Oral squamous cell carcinoma around dental implants.
Czerninski, R., Kaplan, I., Almoznino, G., Maly, A., & Regev, E. (2006) · PubMed · Cited by 62 · see citing works
Clinical performance of two‐piece zirconia implants in the posterior mandible and maxilla: a prospective cohort study over 2 years
Becker, J. C., Gordon, J. C., Becker, K., Mainusch, S., Diedrichs, G., & Schwarz, F. (2015) · Clinical Oral Implants Research · doi:10.1111/clr.12610 · Cited by 61 · see citing works
Self-citation
Prevalence of human cytomegalovirus and Epstein-Barr virus in subgingival plaque at peri-implantitis, mucositis and healthy sites. A pilot study
Jankovic, S., Aleksic, Z. M., Dimitrijević, B., Lekovic, V., Camargo, P. M., & Kenney, B. (2010) · International Journal of Oral and Maxillofacial Surgery · doi:10.1016/j.ijom.2010.11.004 · Cited by 60 · see citing works
Risk factors of peri-implant pathology
Nobre, M. D. A., Azul, A. M., Rocha, E., & Maló, P. S. (2015) · European Journal Of Oral Sciences · doi:10.1111/eos.12185 · Cited by 59 · see citing works
Microbial Profiles and Detection Techniques in Peri-Implant Diseases: a Systematic Review
Padial‐Molina, M., López-Martínez, J., O’Valle, F., & Galindo‐Moreno, P. (2016) · Journal of Oral and Maxillofacial Research · doi:10.5037/jomr.2016.7310 · Cited by 59 · see citing works
Vascular endothelial growth factor and microvessel density around healthy and failing dental implants.
Cornelini, R., Artese, L., Rubini, C., Fioroni, M., Ferrero, G., Santinelli, A., & Piattelli, A. (2001) · PubMed · Cited by 58 · see citing works
History of Chronic Periodontitis Is a High Risk Indicator for Peri-Implant Disease
Casado, P. L., Pereira, M. C., Duarte, M. E. L., & Granjeiro, J. M. (2013) · Brazilian Dental Journal · doi:10.1590/0103-6440201302006 · Cited by 56 · see citing works
An analysis of peripheral giant cell granuloma associated with dental implant treatment
Cloutier, M., Charles, M., Carmichael, R. P., & Sándor, G. K. B. (2006) · Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology · doi:10.1016/j.tripleo.2006.08.003 · Cited by 55 · see citing works
Real-time PCR analysis of fungal organisms and bacterial species at peri-implantitis sites
Schwarz, F., Becker, K., Rahn, S., Hegewald, A., Pfeffer, K., & Henrich, B. (2015) · International Journal of Implant Dentistry · doi:10.1186/s40729-015-0010-6 · Cited by 55 · see citing works
Self-citation
Peripheral Giant Cell Granuloma Associated with Dental Implants
Hirshberg, A., Kozlovsky, A., Schwartz‐Arad, D., Mardinger, O., & Kaplan, I. (2003) · Journal of Periodontology · doi:10.1902/jop.2003.74.9.1381 · Cited by 55 · see citing works
Insufficient irrigation induces peri‐implant bone resorption: an in vivo histologic analysis in sheep
Trisi, P., Berardini, M., Falco, A., Vulpiani, M. P., & Perfetti, G. (2013) · Clinical Oral Implants Research · doi:10.1111/clr.12127 · Cited by 54 · see citing works
Interleukin‐1β and Interleukin‐6 Expression and Gene Polymorphisms in Subjects with Peri‐Implant Disease
Melo, R. F., Lopes, B. M. V., Shibli, J. A., Marcantônio, É., Marcantonio, R. A. C., & Galli, G. M. T. (2011) · Clinical Implant Dentistry and Related Research · doi:10.1111/j.1708-8208.2010.00325.x · Cited by 52 · see citing works
Peri-implant Disease and Chronic Periodontitis: Is Interleukin-6 Gene Promoter Polymorphism the Common Risk Factor in a Brazilian Population?
Casado, P. L., Villas-Bôas, R., de Mello, W., Duarte, M. E. L., & Granjeiro, J. M. (2013) · The International Journal of Oral & Maxillofacial Implants · doi:10.11607/jomi.2867 · Cited by 50 · see citing works
Implant periapical lesions: clinical, histologic, and histochemical aspects. A case report.
Piattelli, A., Scarano, A., Piattelli, M., & Podda, G. (1998) · PubMed · Cited by 49 · see citing works
Effect of the Keratinized Mucosa Width on the Health Status of Periimplant and Contralateral Periodontal Tissues
Ueno, D., Nagano, T., Watanabe, T., Shirakawa, S., Yashima, A., & Gomi, K. (2016) · Implant Dentistry · doi:10.1097/id.0000000000000483 · Cited by 47 · see citing works
Peripheral Giant Cell Granuloma Associated With Dental Implants: Clinical Case and Literature Review
Peñarrocha‐Diago, M., Cervera-Ballester, J., Maestre-Ferrín, L., & Peñarrocha‐Oltra, D. (2012) · Journal of Oral Implantology · doi:10.1563/aaid-joi-d-11-00143 · Cited by 46 · see citing works
The Effect of Interleukin-1 Allele 2 Genotype (IL-1a−889 and IL-1b+3954) on the Individual's Susceptibility to Peri-Implantitis: Case-Control Study
Hamdy, A. A. E.-M. M., & Ebrahem, M. (2010) · Journal of Oral Implantology · doi:10.1563/aaid-joi-d-09-00117.1 · Cited by 45 · see citing works
A cross‐sectional study on the prevalence of marginal bone loss among implant patients
Cecchinato, D., Parpaiola, A., & Lindhe, J. (2012) · Clinical Oral Implants Research · doi:10.1111/j.1600-0501.2012.02457.x · Cited by 45 · see citing works
CD14 and TNFα single nucleotide polymorphisms are candidates for genetic biomarkers of peri-implantitis
Rakić, M., Petković-Ćurčin, A., Struillou, X., Matic, S., Stamatovic, N., & Vojvodić, D. (2014) · Clinical Oral Investigations · doi:10.1007/s00784-014-1313-3 · Cited by 45 · see citing works
Investigation of the Association Between Cement Retention and Prevalent Peri‐Implant Diseases: A Cross‐Sectional Study
Kotsakis, G. A., Zhang, L., Gaillard, P., Raedel, M., Walter, M. H., & Konstantinidis, I. K. (2015) · Journal of Periodontology · doi:10.1902/jop.2015.150450 · Cited by 45 · see citing works
Apical (Retrograde) Peri-implantitis: A Case Report of an Active Lesion
Flanagan, D. (2002) · Journal of Oral Implantology · doi:10.1563/1548-1336(2002)028 · Cited by 43 · see citing works
Oral squamous cell carcinoma in the vicinity of dental implants
Moergel, M., Karbach, J., Kunkel, M., & Wagner, W. (2013) · Clinical Oral Investigations · doi:10.1007/s00784-013-0968-5 · Cited by 43 · see citing works
Primary oral squamous cell carcinoma arising around dental osseointegrated implants mimicking peri-implantitis.
del Valle, A. E., Llamosas, R. M.-C., López Vicente, J., Uribarri, A., & Urízar, J. M. A. (2008) · PubMed · Cited by 42 · see citing works
In Vitro Evaluation of the Effects of Multiple Oral Factors on Dental Implants Surfaces
Sridhar, S., Abidi, Z., Wilson, T. G., Valderrama, P., Wadhwani, C. P. K., Palmer, K. L., & Rodrigues, D. C. (2016) · Journal of Oral Implantology · doi:10.1563/aaid-joi-d-15-00165 · Cited by 41 · see citing works
Retrograde Peri‐Implantitis: A Case Report Introducing an Approach to Its Management
Chan, H., Wang, H., Bashutski, J. D., Edwards, P. C., Fu, J., & Oh, T. (2010) · Journal of Periodontology · doi:10.1902/jop.2010.100585 · Cited by 40 · see citing works
Self-citation
Peripheral giant cell granuloma associated with a dental implant.
Bischof, M., Nedir, R., & Lombardi, T. (2004) · PubMed · Cited by 38 · see citing works
Peri-implant Primary Squamous Cell Carcinoma: A Case Report With 5 Years' Follow-Up
Marini, E., Spink, M. J., & Messina, A. M. (2012) · Journal of Oral and Maxillofacial Surgery · doi:10.1016/j.joms.2012.06.184 · Cited by 34 · see citing works
Peripheral giant cell granuloma associated with dental implants: a rare case report.
Özden, F. O., Özden, B., Kurt, M., Gündüz, K., & Günhan, Ö. (2009) · PubMed · Cited by 34 · see citing works
Correlation between horizontal mucosal thickness and probing depths at healthy and diseased implant sites
Schwarz, F., Claus, C., & Becker, K. (2016) · Clinical Oral Implants Research · doi:10.1111/clr.12932 · Cited by 34 · see citing works
Self-citation
Clinical Outcomes of Peri‐Implant Peripheral Giant Cell Granuloma: A Report of Three Cases
Hernández, G., López‐Pintor, R. M., Torres, J., & de Vicente, J. C. (2009) · Journal of Periodontology · doi:10.1902/jop.2009.090081 · Cited by 33 · see citing works
Cement‐associated peri‐implant mucositis. A 1‐year follow‐up after excess cement removal on the peri‐implant tissue of dental implants
Korsch, M., Walther, W., & Bartols, A. (2017) · Clinical Implant Dentistry and Related Research · doi:10.1111/cid.12470 · Cited by 29 · see citing works
Nonsurgical treatment of retrograde peri-implantitis: a case report.
Waasdorp, J. A., & Reynolds, M. A. (2010) · PubMed · Cited by 26 · see citing works
Metastases and primary tumors around dental implants: A literature review and case report of peri-implant pulmonary metastasis.
Pfammatter, C., Lindenmüller, I. H., Lugli, A., Filippi, A., & Kühl, S. (2012) · PubMed · Cited by 26 · see citing works
Clinical significance of interleukin-1 genotype in smoking patients as a predictor of peri-implantitis: A case-control study
García‐Delaney, C., Sánchez‐Garcés, M. Á., Figueiredo, R., Sánchez‐Torres, A., & Gay‐Escoda, C. (2015) · Medicina oral, patología oral y cirugía bucal · doi:10.4317/medoral.20655 · Cited by 26 · see citing works
Peripheral giant cell granuloma associated with a dental implant. A case report.
Scarano, A., Iezzi, G., Artese, L., Cimorelli, E., & Piattelli, A. (2008) · PubMed · Cited by 25 · see citing works
Osteoprotegerin Gene (OPG) Polymorphisms Associated with Peri-implantitis Susceptibility in a Chinese Han Population
Zhou, J., & Zhao, Y. (2016) · Medical Science Monitor · doi:10.12659/msm.897592 · Cited by 25 · see citing works
Management of Retrograde Peri-implantitis: A Clinical Case Report
Ataullah, K., Loh, F., Peng, L. L., & Lung, H. H. K. (2006) · Journal of Oral Implantology · doi:10.1563/0-802.1 · Cited by 24 · see citing works
The Resolution of a Periradicular Lesion Involving an Implant
Steiner, D. R. (2008) · Journal of Endodontics · doi:10.1016/j.joen.2007.12.001 · Cited by 21 · see citing works
A diversity of peri‐implant mucosal thickness by site
Fuchigami, K., Munakata, M., Kitazume, T., Tachikawa, N., Kasugai, S., & Kuroda, S. (2016) · Clinical Oral Implants Research · doi:10.1111/clr.12778 · Cited by 21 · see citing works
The Importance of Histopathological Diagnosis in the Management of Lesions Presenting as Peri‐Implantitis
Kaplan, I., Hirshberg, A., Shlomi, B., Platner, O., Kozlovsky, A., Ofec, R., & Schwartz‐Arad, D. (2013) · Clinical Implant Dentistry and Related Research · doi:10.1111/cid.12137 · Cited by 20 · see citing works
Analysis of osteoprotegerin (OPG) gene polymorphism in Iranian patients with chronic periodontitis and peri-implantitis. A cross-sectional study.
Kadkhodazadeh, M., Tabari, Z. A., Ardakani, M. R., Ebadian, A. R., & Brook, A. (2012) · PubMed · Cited by 18 · see citing works
Do we need keratinized mucosa for a healthy peri-implant soft tissue?
Esfahanizadeh, N., Daneshparvar, N., Motallebi, S., Akhondi, N., Askarpour, F., & Davaie, S. (2016) · PubMed · Cited by 17 · see citing works
Starch-induced implant periapical lesion: a case report.
Nedir, R., Bischof, M., Pujol, O., Houriet, R., Samson, J., & Lombardi, T. (2007) · PubMed · Cited by 16 · see citing works
Treatment of Refractory Apical Peri-Implantitis: A Case Report
Kutlu, H. B., Genç, T., & Tözüm, T. F. (2014) · Journal of Oral Implantology · doi:10.1563/aaid-joi-d-13-00268 · Cited by 16 · see citing works
The Management of Retrograde Peri-Implantitis: A Case Report
Mohamed, J. B. (2012) · JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH · doi:10.7860/jcdr/2012/4168.2575 · Cited by 16 · see citing works
Inflammatory Implant Periapical Lesion Prior to Osseointegration: A Case Series Study
Peñarrocha‐Diago, M., Maestre-Ferrín, L., Peñarrocha‐Oltra, D., Canullo, L., Piattelli, A., & Diago, M. P. (2013) · The International Journal of Oral & Maxillofacial Implants · doi:10.11607/jomi.2864 · Cited by 12 · see citing works

Flagged first, then by citations

1 of the 166 references couldn’t be matched to a known paper.

Research works printed but not linked: 6

[4]4. Journal of Clinical Periodontology 2012;39 Suppl 12:202-206.
[33]33. Sanz M, Alandez J, Lazaro P, Calvo JL, Quirynen M, van Steenberghe D. Histo-pathologic characteristics of peri-implant soft tissues in Branemark implants with 2 distinct clinical and radiological patterns. Clinical Oral Implants Research 1991;2:128-134.
[79]79. Hanselaer L, Cosyn J, Browaeys H, De Bruyn H. [Giant cell peripheral granuloma surrounding a dental implant: case report]. Revue Belge de Medicine Dentaire (1984) 2010;65:152-158.
[117]117. Ferreira SD, Silva GL, Cortelli JR, Costa JE, Costa FO. Prevalence and risk variables for peri-implant disease in Brazilian subjects. Journal of Clinical Periodontology 2006;33:929-935.
[119]119. Axelsson P, Lindhe J. Effect of controlled oral hygiene procedures on caries and periodontal disease in adults. Journal of Clinical Periodontology 1978;5:133-151.
[152]152. Renvert S, Aghazadeh A, Hallstrom H, Persson GR. Factors related to peri-implantitis -a retrospective study. Clinical Oral Implants Research 2014;25:522-529.

Sorted by citations

A new classification scheme for periodontal and peri‐implant diseases and conditions – Introduction and key changes from the 1999 classification
Caton, J. G., Armitage, G., Berglundh, T., Chapple, I. L. C., Jepsen, S., Kornman, K. S., Mealey, B. L., Papapanou, P. N., Sanz, M., & Tonetti, M. S. (2018) · Journal of Periodontology · doi:10.1002/jper.18-0157 · Cited by 1,845 · see citing works
Peri‐implant diseases and conditions: Consensus report of workgroup 4 of the 2017 World Workshop on the Classification of Periodontal and Peri‐Implant Diseases and Conditions
Berglundh, T., Armitage, G., Araujo, M. G., Avila‐Ortiz, G., Blanco, J., Camargo, P. M., Chen, S., Cochran, D., Derks, J., Figuero, E., et al. (2018) · Journal of Periodontology · doi:10.1002/jper.17-0739 · Cited by 861 · see citing works
Self-citation
Peri‐implant health, peri‐implant mucositis, and peri‐implantitis: Case definitions and diagnostic considerations
Renvert, S., Persson, G. R., Pirih, F. Q., & Camargo, P. M. (2018) · Journal of Periodontology · doi:10.1002/jper.17-0588 · Cited by 367 · see citing works
The peri‐implant phenotype
Ávila‐Ortiz, G., González‐Martín, O., Couso‐Queiruga, E., & Wang, H. (2020) · Journal of Periodontology · doi:10.1002/jper.19-0566 · Cited by 290 · see citing works
Self-citation
Association of prosthetic features and peri‐implantitis: A cross‐sectional study
Yi, Y., Koo, K., Schwarz, F., Amara, H. B., & Heo, S. (2020) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.13251 · Cited by 208 · see citing works
Self-citation
Periodontitis and implant complications in diabetes
Nibali, L., Gkranias, N., Mainas, G., & Pino, A. D. (2022) · Periodontology 2000 · doi:10.1111/prd.12451 · Cited by 177 · see citing works
Implant Disease Risk Assessment IDRA–a tool for preventing peri‐implant disease
Heitz‐Mayfield, L. J. A., Heitz, F., & Lang, N. P. (2020) · Clinical Oral Implants Research · doi:10.1111/clr.13585 · Cited by 169 · see citing works
Veillonellae: Beyond Bridging Species in Oral Biofilm Ecology
Zhou, P., Manoil, D., Belibasakis, G. N., & Kotsakis, G. A. (2021) · Frontiers in Oral Health · doi:10.3389/froh.2021.774115 · Cited by 159 · see citing works
Efficacy of alternative or adjunctive measures to conventional non-surgical and surgical treatment of peri-implant mucositis and peri-implantitis: a systematic review and meta-analysis
Ramanauskaitė, A., Fretwurst, T., & Schwarz, F. (2021) · International Journal of Implant Dentistry · doi:10.1186/s40729-021-00388-x · Cited by 157 · see citing works
Self-citation
Influence of width of keratinized tissue on the prevalence of peri‐implant diseases: A systematic review and meta‐analysis
Ramanauskaitė, A., Schwarz, F., & Sader, R. A. (2022) · Clinical Oral Implants Research · doi:10.1111/clr.13766 · Cited by 157 · see citing works
Self-citation
Use of IL‐1 β, IL‐6, TNF‐α, and MMP‐8 biomarkers to distinguish peri‐implant diseases: A systematic review and meta‐analysis
Ghassib, I. H., Chen, Z., Zhu, J., & Wang, H. (2018) · Clinical Implant Dentistry and Related Research · doi:10.1111/cid.12694 · Cited by 134 · see citing works
Self-citation
Host-microbiome interactions regarding peri-implantitis and dental implant loss
Alves, C. H., Russi, K. L., Rocha, N. C., Bastos, F., Darrieux, M., Parisotto, T. M., & Girardello, R. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03636-9 · Cited by 131 · see citing works
Orthopaedic osseointegration: Implantology and future directions
Overmann, A. L., Aparicio, C., Richards, J. T., Mutreja, I., Fischer, N. G., Wade, S. M., Potter, B. K., Davis, T. A., Bechtold, J. E., Forsberg, J. A., et al. (2019) · Journal of Orthopaedic Research® · doi:10.1002/jor.24576 · Cited by 130 · see citing works
Systematic review on diabetes mellitus and dental implants: an update
Wagner, J., Spille, J. H., Wiltfang, J., & Naujokat, H. (2022) · International Journal of Implant Dentistry · doi:10.1186/s40729-021-00399-8 · Cited by 130 · see citing works
Understanding Peri-Implantitis as a Plaque-Associated and Site-Specific Entity: On the Local Predisposing Factors
Monje, A., Ínsua, Á., & Wang, H. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8020279 · Cited by 119 · see citing works
Self-citation
Titanium particles in peri-implantitis: distribution, pathogenesis and prospects
Chen, L., Tong, Z., Luo, H., Qu, Y., Gu, X., & Si, M. (2023) · International Journal of Oral Science · doi:10.1038/s41368-023-00256-x · Cited by 115 · see citing works
Peri-Implantitis Diagnosis and Prognosis Using Biomarkers in Peri-Implant Crevicular Fluid: A Narrative Review
Alassy, H., Parachuru, P., & Wolff, L. F. (2019) · Diagnostics · doi:10.3390/diagnostics9040214 · Cited by 110 · see citing works
Obesity/Metabolic Syndrome and Diabetes Mellitus on Peri-implantitis
de Oliveira, P. G. F. P., Bonfante, E. A., Bergamo, E. T. P., de Souza, S. L. S., Riella, L. V., Torroni, A., Jalkh, E. B. B., Witek, L., Lopez, C. D., Zambuzzi, W. F., et al. (2020) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2020.05.005 · Cited by 107 · see citing works
Microbiota associated with peri‐implantitis—A systematic review with meta‐analyses
de Carvalho, É. B. S., Romandini, M., Sadilina, S., Sant’Ana, A. C. P., & Sanz, M. (2023) · Clinical Oral Implants Research · doi:10.1111/clr.14153 · Cited by 107 · see citing works
Primordial and primary prevention of peri‐implant diseases: A systematic review and meta‐analysis
Carra, M. C., Blanc‐Sylvestre, N., Courtet, A., & Bouchard, P. (2023) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.13790 · Cited by 106 · see citing works
Laser‐assisted regenerative surgical therapy for peri‐implantitis: A randomized controlled clinical trial
Wang, C., Ashnagar, S., Gianfilippo, R. D., Arnett, M. C., Kinney, J. S., & Wang, H. (2020) · Journal of Periodontology · doi:10.1002/jper.20-0040 · Cited by 102 · see citing works
Self-citation
Three interfaces of the dental implant system and their clinical effects on hard and soft tissues
Kim, J. C., Lee, M., & Yeo, I.-S. L. (2022) · Materials Horizons · doi:10.1039/d1mh01621k · Cited by 95 · see citing works
Prevalence, incidence, systemic, behavioral, and patient‐related risk factors and indicators for peri‐implant diseases: An AO/AAP systematic review and meta‐analysis
Galárraga-Vinueza, M. E., Pagni, S. E., Finkelman, M., Schoenbaum, T. R., & Chambrone, L. (2025) · Journal of Periodontology · doi:10.1002/jper.24-0154 · Cited by 91 · see citing works
Early peri‐implant bone loss as a predictor for peri‐implantitis: A 10‐year prospective cohort study
Windael, S., Collaert, B., Buyser, S. L. D., Bruyn, H. D., & Vervaeke, S. (2021) · Clinical Implant Dentistry and Related Research · doi:10.1111/cid.13000 · Cited by 88 · see citing works
Current Status of Peri-Implant Diseases: A Clinical Review for Evidence-Based Decision Making
Scarano, A., Khater, A. G. A., Gehrke, S. A., Serra, P., Inchingolo, F., Carmine, M. D., Tari, S. R., Leo, L., & Lorusso, F. (2023) · Journal of Functional Biomaterials · doi:10.3390/jfb14040210 · Cited by 88 · see citing works
Compliance with supportive periodontal/peri‐implant therapy: A systematic review
Amerio, E., Mainas, G., Petrova, D., Giner Tarrida, L., Nart, J., & Monje, A. (2020) · Journal of Clinical Periodontology · doi:10.1111/jcpe.13204 · Cited by 87 · see citing works
Self-citation
Fusobacterium nucleatum: The Opportunistic Pathogen of Periodontal and Peri-Implant Diseases
Chen, Y., Shi, T., Li, Y., Huang, L., & Yin, D. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.860149 · Cited by 84 · see citing works
Prevalence and risk indicators of peri‐implantitis in a sample of university‐based dental patients in Italy: A cross‐sectional study
Vignoletti, F., Domenico, G. L. D., Martino, M. D., Montero, E., & Sanctis, M. D. (2019) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.13111 · Cited by 82 · see citing works
Ultrasonography for diagnosis of peri-implant diseases and conditions: a detailed scanning protocol and case demonstration
Chan, H., & Kripfgans, O. D. (2020) · Dentomaxillofacial Radiology · doi:10.1259/dmfr.20190445 · Cited by 82 · see citing works
In the dental implant era, why do we still bother saving teeth?
Clark, D., & Levin, L. (2019) · Dental Traumatology · doi:10.1111/edt.12492 · Cited by 80 · see citing works
Ultrasonographic Tissue Perfusion in Peri-implant Health and Disease
Barootchi, S., Tavelli, L., Majzoub, J., Chan, H., Wang, H., & Kripfgans, O. D. (2021) · Journal of Dental Research · doi:10.1177/00220345211035684 · Cited by 79 · see citing works
Self-citation
Impact of local predisposing/precipitating factors and systemic drivers on peri‐implant diseases
Monje, A., Kan, J. Y. K., & Borgnakke, W. S. (2022) · Clinical Implant Dentistry and Related Research · doi:10.1111/cid.13155 · Cited by 79 · see citing works
Self-citation
Primer on etiology and treatment of progressive/severe periodontitis: A systemic health perspective
Slots, J. (2020) · Periodontology 2000 · doi:10.1111/prd.12325 · Cited by 75 · see citing works
Titanium Wear of Dental Implants from Placement, under Loading and Maintenance Protocols
Romanos, G. E., Fischer, G. A., & Ruiz, R. A. D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031067 · Cited by 75 · see citing works
Implant connection and abutment selection as a predisposing and/or precipitating factor for peri‐implant diseases: A review
Laleman, I., & Lambert, F. (2023) · Clinical Implant Dentistry and Related Research · doi:10.1111/cid.13185 · Cited by 75 · see citing works
Microenvironment‐Regulating Drug Delivery Nanoparticles for Treating and Preventing Typical Biofilm‐Induced Oral Diseases
Xiao, L., Feng, M., Chen, C., Xiao, Q., Cui, Y., & Zhang, Y. (2023) · Advanced Materials · doi:10.1002/adma.202304982 · Cited by 73 · see citing works
Antimicrobial photodynamic therapy versus antibiotics as an adjunct in the treatment of periodontitis and peri-implantitis: A systematic review and meta-analysis
Zhao, Y., Pu, R., Qian, Y., Shi, J., & Si, M. (2021) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2021.102231 · Cited by 72 · see citing works
The sampling strategy of oral microbiome
Lu, H., Zou, P., Zhang, Y., Zhang, Q., Chen, Z., & Chen, F. (2022) · iMeta · doi:10.1002/imt2.23 · Cited by 72 · see citing works
The peri‐implant phenotype and implant esthetic complications. Contemporary overview
Wang, I., Barootchi, S., Tavelli, L., & Wang, H. (2021) · Journal of Esthetic and Restorative Dentistry · doi:10.1111/jerd.12709 · Cited by 70 · see citing works
Self-citation
In vitro efficacy of three different implant surface decontamination methods in three different defect configurations
Keim, D., Nickles, K., Dannewitz, B., Ratka, C., Eickholz, P., & Petsos, H. (2019) · Clinical Oral Implants Research · doi:10.1111/clr.13441 · Cited by 69 · see citing works
Peri-Implant Diseases: Diagnosis, Clinical, Histological, Microbiological Characteristics and Treatment Strategies. A Narrative Review
Kormas, I., Pedercini, C., Pedercini, A., Raptopoulos, M., Alassy, H., & Wolff, L. F. (2020) · Antibiotics · doi:10.3390/antibiotics9110835 · Cited by 68 · see citing works
Adjunctive benefits of systemic metronidazole on non‐surgical treatment of peri‐implantitis. A randomized placebo‐controlled clinical trial
Blanco, C., Pico, A., Dopico, J., Vila, P. G., Blanco, J., & Liñares, A. (2021) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.13564 · Cited by 68 · see citing works
Microbiological Profile and Human Immune Response Associated with Peri‐Implantitis: A Systematic Review
Kensara, A. A., Hefni, E., Williams, M. A., Saito, H., Mongodin, E. F., & Masri, R. M. (2020) · Journal of Prosthodontics · doi:10.1111/jopr.13270 · Cited by 67 · see citing works
Soft tissue features of peri‐implant diseases and related treatment
Galárraga-Vinueza, M. E., & Tavelli, L. (2022) · Clinical Implant Dentistry and Related Research · doi:10.1111/cid.13156 · Cited by 66 · see citing works
Is bleeding on probing a reliable clinical indicator of peri‐implant diseases?
Dukka, H., Saleh, M. H. A., Ravidà, A., Greenwell, H., & Wang, H. (2021) · Journal of Periodontology · doi:10.1002/jper.20-0890 · Cited by 65 · see citing works
Self-citation
Deep learning based dental implant failure prediction from periapical and panoramic films
Zhang, C., Fan, L., Zhang, S., Zhao, J., & Gu, Y. (2023) · Quantitative Imaging in Medicine and Surgery · doi:10.21037/qims-22-457 · Cited by 65 · see citing works
The race for the optimal antimicrobial surface: perspectives and challenges related to plasma electrolytic oxidation coating for titanium-based implants
Costa, R. C., NAGAY, B. E., Dini, C., Borges, M. H. R., Miranda, L. F. B., Cordeiro, J. M., Souza, J. G. S., Sukotjo, C., da Cruz, N. C., & Barão, V. A. R. (2022) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2022.102805 · Cited by 63 · see citing works
Resolution of peri‐implantitis by means of implantoplasty as adjunct to surgical therapy: A retrospective study
Monje, A., Pons, R., Amerio, E., Wang, H., & Nart, J. (2021) · Journal of Periodontology · doi:10.1002/jper.21-0103 · Cited by 62 · see citing works
Self-citation
Therapeutic Applications of Antimicrobial Silver-Based Biomaterials in Dentistry
Wang, Q., Zhang, Y., Li, Q., Chen, L., Liu, H., Ding, M., Dong, H., & Mou, Y. (2022) · International Journal of Nanomedicine · doi:10.2147/ijn.s349238 · Cited by 62 · see citing works
Ten years follow‐up retrospective study on implant survival rates and prevalence of peri‐implantitis in implant‐supported full‐arch rehabilitations
Francetti, L. A., Cavalli, N., Taschieri, S., & Corbella, S. (2019) · Clinical Oral Implants Research · doi:10.1111/clr.13411 · Cited by 61 · see citing works
Cellular expression of DNA damage/repair and reactive oxygen/nitrogen species in human periodontitis and peri‐implantitis lesions
Dionigi, C., Larsson, L., Carcuac, O., & Berglundh, T. (2020) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.13370 · Cited by 60 · see citing works
Biomarker levels in peri‐implant crevicular fluid of healthy implants, untreated and non‐surgically treated implants with peri‐implantitis
Hentenaar, D. F. M., de Waal, Y. C. M., Vissink, A., Winkelhoff, A. J. V., Meijer, H. J. A., Liefers, S. C., Kroese, F. G. M., & Raghoebar, G. M. (2021) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.13423 · Cited by 60 · see citing works
Management and sequelae of dental implant removal
Monje, A., & Nart, J. (2022) · Periodontology 2000 · doi:10.1111/prd.12418 · Cited by 60 · see citing works
Self-citation
Diagnostic methods/parameters to monitor peri‐implant conditions
Monje, A., & Salvi, G. E. (2024) · Periodontology 2000 · doi:10.1111/prd.12584 · Cited by 60 · see citing works
Self-citation
Predictive modeling for peri-implantitis by using machine learning techniques
Mameno, T., Wada, M., Nozaki, K., Takahashi, T., Tsujioka, Y., Akema, S., Hasegawa, D., & Ikebe, K. (2021) · Scientific Reports · doi:10.1038/s41598-021-90642-4 · Cited by 59 · see citing works
Effect of implant cleaning on titanium particle dissolution and cytocompatibility
Kotsakis, G. A., Black, R. M., Kum, J., Berbel, L. O., Sadr, A., Karoussis, I. K., Simopoulou, M., & Daubert, D. M. (2020) · Journal of Periodontology · doi:10.1002/jper.20-0186 · Cited by 59 · see citing works
Hyperlipidemia Impairs Osseointegration via the ROS/Wnt/β-Catenin Pathway
Wang, Y.-N., Jia, T. T., Feng, Y., Liu, S. Y., Zhang, W. J., Zhang, D. J., & Xu, X. (2021) · Journal of Dental Research · doi:10.1177/0022034520983245 · Cited by 58 · see citing works
The lack of keratinized mucosa as a risk factor for peri-implantitis: a systematic review and meta-analysis
Mahardawi, B., Jiaranuchart, S., Damrongsirirat, N., Arunjaroensuk, S., Mattheos, N., Somboonsavatdee, A., & Pimkhaokham, A. (2023) · Scientific Reports · doi:10.1038/s41598-023-30890-8 · Cited by 58 · see citing works
Chronic Stress and Depression in Periodontitis and Peri-Implantitis: A Narrative Review on Neurobiological, Neurobehavioral and Immune–Microbiome Interplays and Clinical Management Implications
D’Ambrosio, F., Caggiano, M., Schiavo, L., Savarese, G., Carpinelli, L., Amato, A., & Iandolo, A. (2022) · Dentistry Journal · doi:10.3390/dj10030049 · Cited by 55 · see citing works
Influence of implant restorative emergence angle and contour on peri‐implant marginal bone loss: A systematic review and meta‐analysis
Atieh, M. A., Shah, M. S., Ameen, M., Tawse‐Smith, A., & Alsabeeha, N. H. M. (2023) · Clinical Implant Dentistry and Related Research · doi:10.1111/cid.13214 · Cited by 54 · see citing works
A Comprehensive Review of Peri-implantitis Risk Factors
Hashim, D., & Cionca, N. (2020) · Current Oral Health Reports · doi:10.1007/s40496-020-00274-2 · Cited by 53 · see citing works
Incidence of Peri-Implantitis and Relationship with Different Conditions: A Retrospective Study
Astolfi, V., Ríos‐Carrasco, B., Gil, J., Ríos-Santos, J., Bullón, B., Herrero‐Climent, M., & Bullón, P. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19074147 · Cited by 53 · see citing works
The progress in titanium alloys used as biomedical implants: From the view of reactive oxygen species
Yang, J., Liu, C., Sun, H. L., Liu, Y., Liu, Z., Zhang, D., Zhao, G. Y., Wang, Q., & Yang, D. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.1092916 · Cited by 53 · see citing works
Customized Subperiosteal Implants for the Rehabilitation of Atrophic Jaws: A Consensus Report and Literature Review
Herce‐López, J., Pingarrón, M. D. C., Tofé‐Povedano, Á., García-Arana, L., Segura-Illa, M. E., Sieira-Gil, R., Alonso, C. R., Sánchez‐Torres, A., & Figueiredo, R. (2024) · Biomimetics · doi:10.3390/biomimetics9010061 · Cited by 53 · see citing works
Influence of restorative design on the progression of peri‐implant bone loss: A retrospective study
Majzoub, J., Chen, Z., Saleh, I., Askar, H., & Wang, H. (2020) · Journal of Periodontology · doi:10.1002/jper.20-0327 · Cited by 53 · see citing works
Self-citation
What is the influence of implant surface characteristics and/or implant material on the incidence and progression of peri‐implantitis? A systematic literature review
Stavropoulos, A., Bertl, K., Winning, L., & Polyzois, I. (2021) · Clinical Oral Implants Research · doi:10.1111/clr.13859 · Cited by 53 · see citing works
Local/Topical Antibiotics for Peri-Implantitis Treatment: A Systematic Review
Passarelli, P. C., Netti, A., López, M. A., Giaquinto, E. F., Rosa, G. D., Aureli, G., Bodnarenko, A., Papi, P., Starzyńska, A., Pompa, G., et al. (2021) · Antibiotics · doi:10.3390/antibiotics10111298 · Cited by 53 · see citing works
Mitigation of Peri-implantitis by Rational Design of Bifunctional Peptides with Antimicrobial Properties
Wisdom, C., Zhou, Y. L., Chen, C., Tamerler, C., & Snead, M. L. (2019) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.9b01213 · Cited by 51 · see citing works
Implant prosthodontic design as a predisposing or precipitating factor for peri‐implant disease: A review
Hamilton, A., Putra, A., Nakaparksin, P., Kamolroongwarakul, P., & Gallucci, G. O. (2023) · Clinical Implant Dentistry and Related Research · doi:10.1111/cid.13183 · Cited by 49 · see citing works
Submucosal microbiome of peri‐implant sites: A cross‐sectional study
Polymeri, A., van der Horst, J., Buijs, M. J., Zaura, E., Wismeijer, D., Wim Crielaard, A., Loos, B. G., Laine, M. L., & Brandt, B. W. (2021) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.13502 · Cited by 49 · see citing works
Improving hard metal implant and soft tissue integration by modulating the “inflammatory-fibrous complex” response
Huang, P., Xu, J., Xie, L., Gao, G., Chen, S., Gong, Z., Lao, X., Shan, Z., Shi, J., Zhou, Z., et al. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.05.013 · Cited by 49 · see citing works
Dental Materials for Oral Microbiota Dysbiosis: An Update
Zhu, J., Chu, W., Luo, J., Yang, J., He, L., & Li, J. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.900918 · Cited by 47 · see citing works
Prevalence, risk indicators, and clinical characteristics of peri‐implant mucositis and peri‐implantitis for an internal conical connection implant system: A multicenter cross‐sectional study
Apaza‐Bedoya, K., Galárraga-Vinueza, M. E., Corrêa, B. B., Schwarz, F., Bianchini, M. A., & Benfatti, C. A. M. (2023) · Journal of Periodontology · doi:10.1002/jper.23-0355 · Cited by 47 · see citing works
Self-citation
Peri-Implantitis Regenerative Therapy: A Review
Mordini, L., Sun, N., Chang, N., Guzman, J.-P. D., Generali, L., & Consolo, U. (2021) · Biology · doi:10.3390/biology10080773 · Cited by 46 · see citing works
Nano-Based Approaches in Surface Modifications of Dental Implants: A Literature Review
Marasli, C., Katifelis, H., Gazouli, M., & Lаgopati, N. (2024) · Molecules · doi:10.3390/molecules29133061 · Cited by 45 · see citing works
Re‐osseointegration following reconstructive surgical therapy of experimental peri‐implantitis. A pre‐clinical in vivo study
Almohandes, A., Carcuac, O., Abrahamsson, I., Lund, H., & Berglundh, T. (2019) · Clinical Oral Implants Research · doi:10.1111/clr.13430 · Cited by 44 · see citing works
Antibacterial Activity against Staphylococcus Aureus of Titanium Surfaces Coated with Graphene Nanoplatelets to Prevent Peri-Implant Diseases. An In-Vitro Pilot Study
Pranno, N., Monaca, G. L., Polimeni, A., Sarto, M. S., Uccelletti, D., Bruni, E., Cristalli, M. P., Cavallini, D., & Vozza, I. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17051568 · Cited by 44 · see citing works
The influence of smoking on the incidence of peri‐implantitis: A systematic review and meta‐analysis
dos Reis, I. N. R., do Amaral, G. C. L. S., Mahmoud, M. A. H., Villar, C. C., Romito, G. A., Spin‐Neto, R., & Pannuti, C. M. (2023) · Clinical Oral Implants Research · doi:10.1111/clr.14066 · Cited by 43 · see citing works
Single‐cell sequencing identifies inflammation‐promoting fibroblast–neutrophil interaction in peri‐implantitis
Mo, J., Lai, Y., Huang, Q., Li, Y., Zhang, Y., Chen, R., & Qian, S. (2023) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.13912 · Cited by 43 · see citing works
Efficacy of bone‐substitute materials use in immediate dental implant placement: A systematic review and meta‐analysis
Zaki, J. G., Yusuf, N., Elkhadem, A., Scholten, R. J. P. M., & Jenniskens, K. (2021) · Clinical Implant Dentistry and Related Research · doi:10.1111/cid.13014 · Cited by 43 · see citing works
Craniofacial therapy: advanced local therapies from nano-engineered titanium implants to treat craniofacial conditions
Gulati, K., Ding, C., Guo, T., Guo, H., Yu, H., & Liu, Y. (2023) · International Journal of Oral Science · doi:10.1038/s41368-023-00220-9 · Cited by 42 · see citing works
Maintenance of peri-implant health in general dental practice
Perussolo, J., & Donos, N. (2024) · BDJ · doi:10.1038/s41415-024-7406-8 · Cited by 42 · see citing works
Reconstructive therapy for the management of peri‐implantitis via submerged guided bone regeneration: A prospective case series
Monje, A., Pons, R., Roccuzzo, A., Salvi, G. E., & Nart, J. (2020) · Clinical Implant Dentistry and Related Research · doi:10.1111/cid.12913 · Cited by 42 · see citing works
Self-citation
Rhamnolipid coating reduces microbial biofilm formation on titanium implants: an in vitro study
Tambone, E., Bonomi, E., Ghensi, P., Maniglio, D., Ceresa, C., Agostinacchio, F., Caciagli, P., Nollo, G., Piccoli, F., Caola, I., et al. (2021) · BMC Oral Health · doi:10.1186/s12903-021-01412-7 · Cited by 42 · see citing works
Comprehensive peri‐implant tissue evaluation with ultrasonography and cone‐beam computed tomography: A pilot study
de Siqueira, R. A. C., Sinjab, K. H., Pan, Y.-C., Soki, F. N., Chan, H., & Kripfgans, O. D. (2021) · Clinical Oral Implants Research · doi:10.1111/clr.13758 · Cited by 42 · see citing works
Clinical efficacy of guided bone regeneration in peri‐implantitis defects. A network meta‐analysis
Ramanauskaitė, A., Becker, K., Cafferata, E. A., & Schwarz, F. (2023) · Periodontology 2000 · doi:10.1111/prd.12510 · Cited by 41 · see citing works
Self-citation
Influence of vertical soft tissue thickness on occurrence of peri‐implantitis in patients with periodontitis: a prospective cohort study
Zhang, Z., Shi, D. M., Meng, H., Han, J., Zhang, L., & Li, W. (2020) · Clinical Implant Dentistry and Related Research · doi:10.1111/cid.12896 · Cited by 40 · see citing works
pH-Responsive Resveratrol-Loaded Electrospun Membranes for the Prevention of Implant-Associated Infections
Bonadies, I., Cristo, F. D., Valentino, A., Peluso, G., Calarco, A., & Salle, A. D. (2020) · Nanomaterials · doi:10.3390/nano10061175 · Cited by 40 · see citing works
Peri-implantitis, systemic inflammation, and dyslipidemia: a cross-sectional biochemical study
Blanco, C., Liñares, A., Dopico, J., Pico, A., Sobrino, T., Leira, Y., & Blanco, J. (2021) · Journal of Periodontal & Implant Science · doi:10.5051/jpis.2100920046 · Cited by 39 · see citing works
In the Dental Implant Era, Why Do We Still Bother Saving Teeth?
Clark, D., & Levin, L. (2019) · Journal of Endodontics · doi:10.1016/j.joen.2019.05.014 · Cited by 39 · see citing works
Evaluation of biofilm colonization on multi-part dental implants in a rat model
Blank, E., Grischke, J., Winkel, A., Eberhard, J., Kommerein, N., Doll, K., Yang, I., & Stiesch, M. (2021) · BMC Oral Health · doi:10.1186/s12903-021-01665-2 · Cited by 39 · see citing works
Silver Nanoparticles Produced by Laser Ablation and Re-Irradiation Are Effective Preventing Peri-Implantitis Multispecies Biofilm Formation
Pérez‐Tanoira, R., Fernández‐Arias, M., Potel, C., Carballo, R., Pérez‐Castro, S., Boutinguiza, M., Górgolas, M., Lusquiños, F., & Pou, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231912027 · Cited by 39 · see citing works
Ion release and local effects of titanium metal particles from dental implants: An experimental study in rats
Toledano‐Serrabona, J., Camps‐Font, O., de Moraes, D. P., Corte‐Rodríguez, M., Montes‐Bayón, M., Valmaseda‐Castellón, E., Gay‐Escoda, C., & Sánchez‐Garcés, M. Á. (2022) · Journal of Periodontology · doi:10.1002/jper.22-0091 · Cited by 38 · see citing works
Interproximal implant thread exposure after initial bone remodeling as a risk indicator for peri‐implantitis
Ravidà, A., Samal, A., Qazi, M., Webber, L. P., Wang, H., Galindo‐Moreno, P., Borgnakke, W. S., & Saleh, M. H. A. (2022) · Journal of Periodontology · doi:10.1002/jper.22-0499 · Cited by 38 · see citing works
Self-citation
Influence of Implant–Abutment Connection Biomechanics on Biological Response: A Literature Review on Interfaces between Implants and Abutments of Titanium and Zirconia
Choi, S., Kang, Y. S., & Yeo, I.-S. L. (2023) · Prosthesis · doi:10.3390/prosthesis5020036 · Cited by 38 · see citing works
Tremella-Like ZnO@Col-I-Decorated Titanium Surfaces with Dual-Light-Defined Broad-Spectrum Antibacterial and Triple Osteogenic Properties
Zhao, S., Xu, Y., Xu, W., Weng, Z., Cao, F., Wan, X., Cui, T., Yu, Y., Liao, L., & Wang, X. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c05413 · Cited by 38 · see citing works
Titanium vs ceramic single dental implants in the anterior maxilla: A 12‐month randomized clinical trial
Henao, P. A. R., Caneiro, L., Mareque, S., Pereiro, A. T., Liñares, A., & Blanco, J. (2021) · Clinical Oral Implants Research · doi:10.1111/clr.13788 · Cited by 38 · see citing works
Wnt5a is involved in LOX‐1 and TLR4 induced host inflammatory response in peri‐implantitis
Zhang, Q., Liu, J., Ma, L., Bai, N., & Xu, H. (2019) · Journal of Periodontal Research · doi:10.1111/jre.12702 · Cited by 37 · see citing works
Long‐term results of implants and i mplant‐supported prostheses under systematic supportive implant therapy: A retrospective 25‐year study
Frisch, E., Wild, V., Ratka‐Krüger, P., Vach, K., & Sennhenn‐Kirchner, S. (2020) · Clinical Implant Dentistry and Related Research · doi:10.1111/cid.12944 · Cited by 37 · see citing works
Dual-functionalized titanium by ultrafast laser texturing to enhance human gingival fibroblasts adhesion and minimize Porphyromonas gingivalis colonization
Papa, S., Khalil, A. A., Hamzeh‐Cognasse, H., Thomas, M., Maalouf, M., Maïo, Y. D., Sedao, X., Guignandon, A., & Dumas, V. (2022) · Applied Surface Science · doi:10.1016/j.apsusc.2022.154784 · Cited by 37 · see citing works

Peri‐implant mucositis
Heitz‐Mayfield, L. J. A., & Salvi, G. E. (2018) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.12953 · Cited by 409 · see citing works
Peri-implantitis: etiology, diagnosis and treatment: an update.
Elemek, E., & Almas, K. (2014) · PubMed · Cited by 25 · see citing works
RESEARCH ARTICLE Different contribution of B
Vieira, R. R. (2016)
Prevalence and Etiology for Peri-implant Diseases
Ogata, Y. (2020) · Springer eBooks · doi:10.1007/978-3-030-39185-0_1 · Cited by 1 · see citing works
Peri‐implant diseases and conditions: Consensus report of workgroup 4 of the 2017 World Workshop on the Classification of Periodontal and Peri‐Implant Diseases and Conditions
Berglundh, T., Armitage, G., Araujo, M. G., Avila‐Ortiz, G., Blanco, J., Camargo, P. M., Chen, S., Cochran, D., Derks, J., Figuero, E., et al. (2018) · Journal of Periodontology · doi:10.1002/jper.17-0739 · Cited by 861 · see citing works
Self-citation

Authors: Schwarz, F., Derks, J., Monje, A., & Wang, H.
Affiliations: Goethe University Frankfurt (DE)
University of Gothenburg (SE)
University of Bern (CH)
University of Michigan (US)
Corresponding author: Schwarz, Frank
ORCID: Schwarz, Frank
Monje, Alberto
Wang, Hom‐Lay
Venue: Journal of Periodontology
Publisher: Wiley
Published: 2018-06
Volume: 89
Issue: S1
Pages: S267-S290
ISSN: 0022-3492 (ISSN-L)
1943-3670
DOI: 10.1002/jper.16-0350
OpenAlex: W4211093662
Cited by: 723
References: 166
Citations by year: 2026: 53 · 2025: 72 · 2024: 99 · 2023: 132 · 2022: 132 · 2021: 102 · 2020: 89 · 2019: 38 · 2018: 6
FWCI: 11.30
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 20 d)
Locations: Journal of Periodontology (publishedVersion)
PubMed (publishedVersion)
Deep Blue (University of Michigan) (submittedVersion)
Funders: University of Michigan
Osteology Foundation
Electro Medical Systems
DENTSPLY Implants
Geistlich Pharma
Oral Reconstruction Foundation
Topics: Health Sciences › Dentistry › Oral Surgery › Dental Implant Techniques and Outcomes
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
Keywords: peri-implantitis, peri-implant mucositis, dental implants, marginal bone loss, disease progression, risk factors, chronic periodontitis, plaque control, smoking, diabetes mellitus, keratinized mucosa, histopathology
MeSH terms: Dental Plaque, Humans, Oral Hygiene, Risk Factors, Stomatitis, Dental Implants, Alveolar Bone Loss, Peri-Implantitis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Peri‐implantitis

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks